RBR1_CANAL
ID RBR1_CANAL Reviewed; 111 AA.
AC Q5A6M0; A0A1D8PSS8;
DT 11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Repressed By RIM101 protein 1;
DE AltName: Full=Predicted GPI-anchored protein 20;
DE Flags: Precursor;
GN Name=RBR1; Synonyms=PGA20; OrderedLocusNames=CAALFM_CR04440CA;
GN ORFNames=CaO19.535, CaO19.8168;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP PREDICTION OF GPI-ANCHOR.
RX PubMed=12845604; DOI=10.1002/yea.1007;
RA De Groot P.W., Hellingwerf K.J., Klis F.M.;
RT "Genome-wide identification of fungal GPI proteins.";
RL Yeast 20:781-796(2003).
RN [5]
RP INDUCTION, AND FUNCTION.
RX PubMed=15189998; DOI=10.1128/ec.3.3.776-784.2004;
RA Lotz H., Sohn K., Brunner H., Muhlschlegel F.A., Rupp S.;
RT "RBR1, a novel pH-regulated cell wall gene of Candida albicans, is
RT repressed by RIM101 and activated by NRG1.";
RL Eukaryot. Cell 3:776-784(2004).
RN [6]
RP INDUCTION.
RX PubMed=18799621; DOI=10.1091/mbc.e08-05-0479;
RA Alvarez F.J., Douglas L.M., Rosebrock A., Konopka J.B.;
RT "The Sur7 protein regulates plasma membrane organization and prevents
RT intracellular cell wall growth in Candida albicans.";
RL Mol. Biol. Cell 19:5214-5225(2008).
RN [7]
RP INDUCTION.
RX PubMed=21592964; DOI=10.1074/jbc.m111.233569;
RA Singh R.P., Prasad H.K., Sinha I., Agarwal N., Natarajan K.;
RT "Cap2-HAP complex is a critical transcriptional regulator that has dual but
RT contrasting roles in regulation of iron homeostasis in Candida albicans.";
RL J. Biol. Chem. 286:25154-25170(2011).
CC -!- FUNCTION: Probable cell wall protein required for filamentation at low
CC pH. {ECO:0000269|PubMed:15189998}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000305}. Membrane
CC {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
CC -!- INDUCTION: Expressed under acidic conditions. Expression is positively
CC regulated by HAP43 and NRG1, and repressed by RIM101. Expression is
CC also controlled by SUR7. {ECO:0000269|PubMed:15189998,
CC ECO:0000269|PubMed:18799621, ECO:0000269|PubMed:21592964}.
CC -!- PTM: The GPI-anchor is attached to the protein in the endoplasmic
CC reticulum and serves to target the protein to the cell surface. There,
CC the glucosamine-inositol phospholipid moiety is cleaved off and the
CC GPI-modified mannoprotein is covalently attached via its lipidless GPI
CC glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By
CC similarity). {ECO:0000250}.
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DR EMBL; CP017630; AOW31180.1; -; Genomic_DNA.
DR RefSeq; XP_717398.1; XM_712305.2.
DR AlphaFoldDB; Q5A6M0; -.
DR STRING; 237561.Q5A6M0; -.
DR GeneID; 3640986; -.
DR KEGG; cal:CAALFM_CR04440CA; -.
DR CGD; CAL0000198834; RBR1.
DR VEuPathDB; FungiDB:CR_04440C_A; -.
DR HOGENOM; CLU_169106_0_0_1; -.
DR OMA; HEYHAPG; -.
DR PRO; PR:Q5A6M0; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0036244; P:cellular response to neutral pH; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036178; P:filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
DR InterPro; IPR001058; Synuclein.
DR PRINTS; PR01211; SYNUCLEIN.
PE 1: Evidence at protein level;
KW Cell wall; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..81
FT /note="Repressed By RIM101 protein 1"
FT /id="PRO_0000424779"
FT PROPEP 82..111
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000424780"
FT REGION 71..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 81
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 111 AA; 9530 MW; 560553C2D581B960 CRC64;
MKFSTTLLAL TASIAAVMSA DSSAAASGAA SAASGAKSGA TSAASGAKSG ASSVASAAKS
GVSSAASAAK SGASSATGGS SAAKSGSSSG AGFAPVAGAG SLAAIAGLLL L
