ID   RBR1_NICBE              Reviewed;        1003 AA.
AC   Q66WV0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Retinoblastoma-related protein 1;
DE            Short=NbRBR1;
GN   Name=RBR1;
OS   Nicotiana benthamiana.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4100;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=15807779; DOI=10.1111/j.1365-313x.2005.02361.x;
RA   Park J.-A., Ahn J.-W., Kim Y.-K., Kim S.J., Kim J.-K., Kim W.T., Pai H.-S.;
RT   "Retinoblastoma protein regulates cell proliferation, differentiation, and
RT   endoreduplication in plants.";
RL   Plant J. 42:153-163(2005).
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. Formation of stable
CC       complexes with geminiviridae replication-associated proteins may create
CC       a cellular environment which favors viral DNA replication (By
CC       similarity). May play a role in the entry into mitosis, negatively
CC       regulating the cell proliferation during leaf, stem, and flower
CC       development. Critical regulator of the endocycle. {ECO:0000250,
CC       ECO:0000269|PubMed:15807779}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, stems, leaves and flowers.
CC       {ECO:0000269|PubMed:15807779}.
CC   -!- MISCELLANEOUS: Plants undergoing virus-induced gene silencing (VIGS)
CC       exhibit clusters of undifferentiated cells around mature stomata,
CC       indicating uncontrolled cell division from meristemoids, as well as
CC       increased ploidy level in some cells.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; AY699399; AAU05979.1; -; mRNA.
DR   AlphaFoldDB; Q66WV0; -.
DR   SMR; Q66WV0; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051782; P:negative regulation of cell division; IMP:UniProtKB.
DR   GO; GO:0032875; P:regulation of DNA endoreduplication; IMP:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1003
FT                   /note="Retinoblastoma-related protein 1"
FT                   /id="PRO_0000380236"
FT   REGION          405..860
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          405..607
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          608..729
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          730..860
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
FT   REGION          868..899
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1003 AA;  111679 MW;  903293523893E8B9 CRC64;
     MVELNNCSNS EETGGVDSLE VRFTDFCKNG LSMGESFVTE ATKLFNDSKH LLLSNNSTIG
     VITQEGVERY WFVFVLYSVK RLSEKEAGNS NNGDKGNAFS LCQILRGAKL NVVDFFKELP
     QFILKVGPTL SNLYGSDWEK RLEVKELQTN FVHLSLLSKY YKRAYQELFL ASGNNEDKPS
     ATSNSAIHLP QYYRFGWLLF LSLRIHVFSR FKDLVTCTNG LVSVLAILMI HVPVRFRNFN
     IDDSSRFVKK GDKVDLLASL SKIYQTSIDD LRETMDKVNN LITEKLKKKP CLASEFRTEN
     LDNLDTDGLT YFEDLMEESC LSSSVSTLEK DYSDAIQNKG ELDERIFVNE EDSLLGSGSL
     SGGAVNMNGT KRKFDAMASP AKTVTSTLSP YRSPNCANSK MTAATPVSTA MTTARWLRTV
     IAPLQPKPSA ELERFLSSCD RDVTADVIRR AQIILEAIFP SSGPAEHCAA GGSLQSTSLM
     DNIWAEQRRS EALKLYYRVL QTMCTAESQI LNGNNLTSLL TNERFHRCML ACSAELVLAT
     HKTVTMLFPA VLERTGITAF DLSKVIESFI RHEESLPREL RRHLNSLEER LLESMVWEKG
     SSMYNSLAVA KPSLAAEINR MGLLAEPMPS LDAIAMHINL SSGSLPPLPS LHKNNLAPNG
     QIGDIRSPKK VCSEYRSVLV ERNSFTSPVK DRFLALNNIK SKFPPPALHS AFASPTRPNP
     GGGGETCAET AINVFFGKIV KLAAVRINGM IERLQLSQQI RETVYCLFQK ILSQRTSLFF
     NRHIDQIILC SFYGVAKISQ LNLTFKEIIC NYRKQPQCKP QVFRSVFVDW TLARHNVRTG
     ADHVDIITFY NEMFIPSVKP LLVELAPAGN NSEKNDHNDG QGPASPKPSP FPKLPDMSPK
     KVSAVHNVYV SPLRASKMDA LISHSSKSYY ACVGESTHAY QSPSKDLDVI NNRLNGNRKL
     RGALNFDVDA GLVSDSIVAN SLYLQNGNCR SPVAHVKTEQ PES