RBR1_ORYSI
ID RBR1_ORYSI Reviewed; 1010 AA.
AC A2YXJ7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Retinoblastoma-related protein 1;
DE Short=OsRBR1;
GN Name=RBR1; ORFNames=OsI_029040;
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Regulator of biological processes that recruits a histone
CC deacetylase to control gene transcription. May play a role in the entry
CC into mitosis, negatively regulating the cell proliferation. Formation
CC of stable complexes with geminiviridae replication-associated proteins
CC may create a cellular environment which favors viral DNA replication
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000305}.
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DR EMBL; CM000133; EAZ07808.1; -; Genomic_DNA.
DR AlphaFoldDB; A2YXJ7; -.
DR SMR; A2YXJ7; -.
DR STRING; 39946.A2YXJ7; -.
DR PRIDE; A2YXJ7; -.
DR EnsemblPlants; BGIOSGA026573-TA; BGIOSGA026573-PA; BGIOSGA026573.
DR Gramene; BGIOSGA026573-TA; BGIOSGA026573-PA; BGIOSGA026573.
DR HOGENOM; CLU_015949_0_0_1; -.
DR OMA; AILCELH; -.
DR Proteomes; UP000007015; Chromosome 8.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:InterPro.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR InterPro; IPR015652; RBR.
DR PANTHER; PTHR13742; PTHR13742; 1.
DR PANTHER; PTHR13742:SF30; PTHR13742:SF30; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 3: Inferred from homology;
KW Cell cycle; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1010
FT /note="Retinoblastoma-related protein 1"
FT /id="PRO_0000335250"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..861
FT /note="Pocket"
FT REGION 419..619
FT /note="Domain A"
FT REGION 620..730
FT /note="Spacer"
FT REGION 657..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..861
FT /note="Domain B"
FT REGION 868..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1010 AA; 111509 MW; CF066328DFBF9591 CRC64;
MEGAAPPASS GSEVTGAGSG KVDAGGGAAM EERFADLCKS KLGLDESITR QAMQLFKESK
SILLSSMSSL GSGSPEEIER FWSAFVLYCV SRLGKAGKGK EDGGISLCQI LRAFSLNIVD
FFKEMPQFCI KVGSVLAGLY GSDWEKRLEL KELQANVVHL SLLSRYYKRA YQELFLLNDA
KPPENSAEPN AQASDYYRFG WLLFLVLRIQ TFSRFKDLVT STNGLVSVLA VLIVHIPVRL
RNFNIKESSS FAKKSDKGVN LIASLCEKYH TSEDELSKAI EKTNTLIVDI LKKKPCPAAS
ECQQDRLSFI DPEGLTYFKN LLEEDSLKLS LLMLEKEYEN AINTKGELDE RMFANDEDSL
LGSGSLSGGA INLPGTKRKY DVMASPAKSI TSPSPMSPPR FCASPTGNGY CSSKMAPITP
VSTAMTTAKW LRSTISPLPS KPSGELLRFF SACDKDVTDD ITRRAGIILG AIFTSSSFGE
RICTSVRSTN RIDAIWTEQR KMEALKLYYR VLESMCRAET QILSGNNLTS LLSNERFHRC
MIACSAELVL ATHKTVTMMF PAVLEKTGIT AFDLSKVIES FVRHEDTLPR ELKRHLNSLE
ERLLESMAWE KGSSMYNSLI VARPTLSAEI NRLGLLAEPM PSLDAIAAHH NISLEGLPPL
PFQKQEHSPD KDEVRSPKRA CTERRNVLVD NNSFRSPVKD TLKSKLPPLQ SAFLSPTRPN
PAAGGELCAE TGIGVFLSKI AKLAAIRIRG LCERLQLSQQ VLERVYSLVQ QIIIQQTALF
FNRHIDQIIL CSIYGVAKIS QLALTFKEII FGYRKQSQCK PQVFRSVYVH WASRSRNGKT
GEDHVDIITF YNEVFIPTVK PLLVELGSGT SPNKKNEEKC AADGPYPESP RLSRFPNLPD
MSPKKVSAAH NVYVSPLRTS KMDTLLSPSS KSYYACVGES THAFQSPSKD LKVINNRLNS
GKKVSGRLNF DVVSDLVVAR SLSDQNSASA AATTADITTK TPVKLEQPDC
