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RBR1_ORYSJ
ID   RBR1_ORYSJ              Reviewed;        1010 AA.
AC   Q84QM3; A0A0P0XI99; A2ZWA7; A9UL15; B7F8C8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Retinoblastoma-related protein 1;
DE            Short=OsRBR1;
GN   Name=RBR1; OrderedLocusNames=Os08g0538700, LOC_Os08g42600;
GN   ORFNames=OsJ_002829, P0666G10.104;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Taipei 309;
RX   PubMed=17389586; DOI=10.1093/jxb/erm022;
RA   Lendvai A., Pettko-Szandtner A., Csordas-Toth E., Miskolczi P.,
RA   Horvath G.V., Gyoergyey J., Dudits D.;
RT   "Dicot and monocot plants differ in retinoblastoma-related protein
RT   subfamilies.";
RL   J. Exp. Bot. 58:1663-1675(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RG   The rice full-length cDNA consortium;
RT   "Oryza sativa full length cDNA.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAF24286.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EAZ13004.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY941774; AAY23368.1; -; mRNA.
DR   EMBL; AP004592; BAC75848.1; -; Genomic_DNA.
DR   EMBL; AP008214; BAF24286.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014964; BAT06468.1; -; Genomic_DNA.
DR   EMBL; CM000138; EAZ13004.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AK240830; BAH00876.1; -; mRNA.
DR   EMBL; AK241627; BAH01069.1; -; mRNA.
DR   RefSeq; XP_015648673.1; XM_015793187.1.
DR   AlphaFoldDB; Q84QM3; -.
DR   SMR; Q84QM3; -.
DR   STRING; 4530.OS08T0538700-01; -.
DR   iPTMnet; Q84QM3; -.
DR   PaxDb; Q84QM3; -.
DR   PRIDE; Q84QM3; -.
DR   EnsemblPlants; Os08t0538700-01; Os08t0538700-01; Os08g0538700.
DR   EnsemblPlants; Os08t0538700-02; Os08t0538700-02; Os08g0538700.
DR   GeneID; 4346176; -.
DR   Gramene; Os08t0538700-01; Os08t0538700-01; Os08g0538700.
DR   Gramene; Os08t0538700-02; Os08t0538700-02; Os08g0538700.
DR   KEGG; osa:4346176; -.
DR   eggNOG; KOG1010; Eukaryota.
DR   HOGENOM; CLU_015949_0_0_1; -.
DR   InParanoid; Q84QM3; -.
DR   OMA; AILCELH; -.
DR   OrthoDB; 113612at2759; -.
DR   PlantReactome; R-OSA-9640887; G1/S transition.
DR   Proteomes; UP000000763; Chromosome 8.
DR   Proteomes; UP000007752; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 8.
DR   Genevisible; Q84QM3; OS.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:InterPro.
DR   GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR015030; RB_C.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   InterPro; IPR015652; RBR.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   PANTHER; PTHR13742:SF30; PTHR13742:SF30; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SMART; SM01369; Rb_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1010
FT                   /note="Retinoblastoma-related protein 1"
FT                   /id="PRO_0000335249"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          419..861
FT                   /note="Pocket"
FT   REGION          419..619
FT                   /note="Domain A"
FT   REGION          620..730
FT                   /note="Spacer"
FT   REGION          657..679
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          731..861
FT                   /note="Domain B"
FT   REGION          868..898
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        665..679
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        867
FT                   /note="G -> R (in Ref. 1; AAY23368)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1010 AA;  111479 MW;  CF066328CFBE9591 CRC64;
     MEGAAPPASS GSEVTGAGSG KVDAGGGAAM EERFADLCKS KLGLDESITR QAMQLFKESK
     SILLSSMSSL GSGSPEEIER FWSAFVLYCV SRLGKAGKGK EDGGISLCQI LRAFSLNIVD
     FFKEMPQFCI KVGSVLAGLY GSDWEKRLEL KELQANVVHL SLLSRYYKRA YQELFLLNDA
     KPPENSAEPN AQASDYYRFG WLLFLVLRIQ TFSRFKDLVT STNGLVSVLA VLIVHIPVRL
     RNFNIKESSS FAKKSDKGVN LIASLCEKYH TSEDELSKAI EKTNTLIVDI LKKKPCPAAS
     ECQQDRLSFI DPEGLTYFKN LLEEDSLKLS LLMLEKEYEN AINTKGELDE RMFANDEDSL
     LGSGSLSGGA INLPGTKRKY DVMASPAKSI TSPSPMSPPR FCASPTGNGY CSSKMAPITP
     VSTAMTTAKW LRSTISPLPS KPSGELLRFF SACDKDVTDD ITRRAGIILG AIFTSSSFGE
     RICTSVRSTN RIDAIWTEQR KMEALKLYYR VLESMCRAET QILSGNNLTS LLSNERFHRC
     MIACSAELVL ATHKTVTMMF PAVLEKTGIT AFDLSKVIES FVRHEDTLPR ELKRHLNSLE
     ERLLESMAWE KGSSMYNSLI VARPTLSAEI NRLGLLAEPM PSLDAIAAHH NISLEGLPPL
     PFQKQEHSPD KDEVRSPKRA CTERRNVLVD NNSFRSPVKD TLKSKLPPLQ SAFLSPTRPN
     PAAGGELCAE TGIGVFLSKI AKLAAIRIRG LCERLQLSQQ VLERVYSLVQ QIIIQQTALF
     FNRHIDQIIL CSIYGVAKIS QLALTFKEII FGYRKQSQCK PQVFRSVYVH WASRSRNGKT
     GEDHVDIITF YNEVFIPTVK PLLVELGSGT SPNKKNEEKC AADGPYPESP RLSRFPNLPD
     MSPKKVSAAH NVYVSPLRTS KMDTLLSPSS KSYYACVGES THAFQSPSKD LKVINNRLNS
     GKKVSGRLNF DVVSDLVVAR SLSDQNSASA AATTADIATK TPVKLEQPDC
 
 
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