RBR1_ORYSJ
ID RBR1_ORYSJ Reviewed; 1010 AA.
AC Q84QM3; A0A0P0XI99; A2ZWA7; A9UL15; B7F8C8;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Retinoblastoma-related protein 1;
DE Short=OsRBR1;
GN Name=RBR1; OrderedLocusNames=Os08g0538700, LOC_Os08g42600;
GN ORFNames=OsJ_002829, P0666G10.104;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Taipei 309;
RX PubMed=17389586; DOI=10.1093/jxb/erm022;
RA Lendvai A., Pettko-Szandtner A., Csordas-Toth E., Miskolczi P.,
RA Horvath G.V., Gyoergyey J., Dudits D.;
RT "Dicot and monocot plants differ in retinoblastoma-related protein
RT subfamilies.";
RL J. Exp. Bot. 58:1663-1675(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RG The rice full-length cDNA consortium;
RT "Oryza sativa full length cDNA.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulator of biological processes that recruits a histone
CC deacetylase to control gene transcription. May play a role in the entry
CC into mitosis, negatively regulating the cell proliferation. Formation
CC of stable complexes with geminiviridae replication-associated proteins
CC may create a cellular environment which favors viral DNA replication
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF24286.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAZ13004.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY941774; AAY23368.1; -; mRNA.
DR EMBL; AP004592; BAC75848.1; -; Genomic_DNA.
DR EMBL; AP008214; BAF24286.2; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014964; BAT06468.1; -; Genomic_DNA.
DR EMBL; CM000138; EAZ13004.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK240830; BAH00876.1; -; mRNA.
DR EMBL; AK241627; BAH01069.1; -; mRNA.
DR RefSeq; XP_015648673.1; XM_015793187.1.
DR AlphaFoldDB; Q84QM3; -.
DR SMR; Q84QM3; -.
DR STRING; 4530.OS08T0538700-01; -.
DR iPTMnet; Q84QM3; -.
DR PaxDb; Q84QM3; -.
DR PRIDE; Q84QM3; -.
DR EnsemblPlants; Os08t0538700-01; Os08t0538700-01; Os08g0538700.
DR EnsemblPlants; Os08t0538700-02; Os08t0538700-02; Os08g0538700.
DR GeneID; 4346176; -.
DR Gramene; Os08t0538700-01; Os08t0538700-01; Os08g0538700.
DR Gramene; Os08t0538700-02; Os08t0538700-02; Os08g0538700.
DR KEGG; osa:4346176; -.
DR eggNOG; KOG1010; Eukaryota.
DR HOGENOM; CLU_015949_0_0_1; -.
DR InParanoid; Q84QM3; -.
DR OMA; AILCELH; -.
DR OrthoDB; 113612at2759; -.
DR PlantReactome; R-OSA-9640887; G1/S transition.
DR Proteomes; UP000000763; Chromosome 8.
DR Proteomes; UP000007752; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 8.
DR Genevisible; Q84QM3; OS.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:InterPro.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR InterPro; IPR015652; RBR.
DR PANTHER; PTHR13742; PTHR13742; 1.
DR PANTHER; PTHR13742:SF30; PTHR13742:SF30; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Cell cycle; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1010
FT /note="Retinoblastoma-related protein 1"
FT /id="PRO_0000335249"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..861
FT /note="Pocket"
FT REGION 419..619
FT /note="Domain A"
FT REGION 620..730
FT /note="Spacer"
FT REGION 657..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..861
FT /note="Domain B"
FT REGION 868..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..679
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 867
FT /note="G -> R (in Ref. 1; AAY23368)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1010 AA; 111479 MW; CF066328CFBE9591 CRC64;
MEGAAPPASS GSEVTGAGSG KVDAGGGAAM EERFADLCKS KLGLDESITR QAMQLFKESK
SILLSSMSSL GSGSPEEIER FWSAFVLYCV SRLGKAGKGK EDGGISLCQI LRAFSLNIVD
FFKEMPQFCI KVGSVLAGLY GSDWEKRLEL KELQANVVHL SLLSRYYKRA YQELFLLNDA
KPPENSAEPN AQASDYYRFG WLLFLVLRIQ TFSRFKDLVT STNGLVSVLA VLIVHIPVRL
RNFNIKESSS FAKKSDKGVN LIASLCEKYH TSEDELSKAI EKTNTLIVDI LKKKPCPAAS
ECQQDRLSFI DPEGLTYFKN LLEEDSLKLS LLMLEKEYEN AINTKGELDE RMFANDEDSL
LGSGSLSGGA INLPGTKRKY DVMASPAKSI TSPSPMSPPR FCASPTGNGY CSSKMAPITP
VSTAMTTAKW LRSTISPLPS KPSGELLRFF SACDKDVTDD ITRRAGIILG AIFTSSSFGE
RICTSVRSTN RIDAIWTEQR KMEALKLYYR VLESMCRAET QILSGNNLTS LLSNERFHRC
MIACSAELVL ATHKTVTMMF PAVLEKTGIT AFDLSKVIES FVRHEDTLPR ELKRHLNSLE
ERLLESMAWE KGSSMYNSLI VARPTLSAEI NRLGLLAEPM PSLDAIAAHH NISLEGLPPL
PFQKQEHSPD KDEVRSPKRA CTERRNVLVD NNSFRSPVKD TLKSKLPPLQ SAFLSPTRPN
PAAGGELCAE TGIGVFLSKI AKLAAIRIRG LCERLQLSQQ VLERVYSLVQ QIIIQQTALF
FNRHIDQIIL CSIYGVAKIS QLALTFKEII FGYRKQSQCK PQVFRSVYVH WASRSRNGKT
GEDHVDIITF YNEVFIPTVK PLLVELGSGT SPNKKNEEKC AADGPYPESP RLSRFPNLPD
MSPKKVSAAH NVYVSPLRTS KMDTLLSPSS KSYYACVGES THAFQSPSKD LKVINNRLNS
GKKVSGRLNF DVVSDLVVAR SLSDQNSASA AATTADIATK TPVKLEQPDC