ID   RBR1_PEA                Reviewed;        1026 AA.
AC   Q9SLZ4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Retinoblastoma-related protein 1;
DE            Short=PsRB1;
GN   Name=RBR1;
OS   Pisum sativum (Garden pea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Fabeae; Pisum.
OX   NCBI_TaxID=3888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Axillary bud;
RA   Shimizu S., Mori H.;
RT   "PSRB1 encodes pea retinoblastoma-related protein that interacts with a
RT   plant D-type cyclin.";
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; AB012024; BAA88690.1; -; mRNA.
DR   AlphaFoldDB; Q9SLZ4; -.
DR   SMR; Q9SLZ4; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1026
FT                   /note="Retinoblastoma-related protein 1"
FT                   /id="PRO_0000380237"
FT   REGION          416..872
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          416..616
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          617..737
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          656..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          738..872
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
FT   REGION          1007..1026
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1026 AA;  114476 MW;  F00294D30E4DE1B2 CRC64;
     MSLPAETDME DTKPSVVMVD NGDQAQFRFA EFSKNELALD EKSCKEAMDL FGETKHLLVA
     NVLSMGNGTT EEAERNWFAF ILYSIKKLAQ KNEEIQKDEI ENTGLTLCRI LRAAKLNIAE
     FFKELPQFVV KAGPILSNLY GPDWENKLEA KEMHANTIHL KILSKYYKRV FEEFFVSTDA
     NVENNSSVTN RVSEYHRFGW LLFLALRVHA FSRFKDLVTC TNGLISILAI LIIHVPARFR
     SFNIHDSSRF VKKSANGVDL LASLCNLYNT SEDELRKTIE QANNLVADIL KKKPCLASEC
     ETENLENFDR DGLTYFKDLM EESSLPSSLS VLENDYDHMT RNNGELDERL FINEDDSLLA
     SGSLSRGSVS AGGVKRKIDL MTSPTKMITS PLSPHRSPAS HANGIPSSAT PMIAATPVST
     AMTTAKWLRT VISPLPSKPS QELERFLTSC DKDITSDVIR RAQIILQAIF PSSPLGDRCV
     TGSLQSANLM DNIWAEQRRL EALKLYYRVL ATMCRAEAQI LGNNLTSLLT NERFHRCMLA
     CSAELVLATH KTVTMLFPAV LERTGITAFD LSKVIESFIR YEESLPRELR RHLNSLEERL
     LESLVWEKGS SMYNSLAVAR PALSVEINRL GLLAEPMRSL DEIAMDINFS CGGLPPVPSL
     PKPEPMSAQN GDPRSPKRPC TEHRNVLAER NSFTSPVKDR LLHLSNLKSK LLPPPLQSAF
     ASPTKPNPGG GGETCAETGI SVFFSKIVKL GAVRISGMVE RLQLSQQIRE NVYCLFQRIL
     NQWTSLFFNR HIDQIILCCF YGVAKISQLN LTFREIIYNY RKQPQCKPEV FRSVFVDWSS
     ARRNGSCKQR TGQEHIDIIS FYNEVFIPSV KPLLVEIGPG GATTRNDRIP EANNKNDGHL
     AQCPGSPRIS PFPSLPDMSP KKVSATHNVY VSPLRSSKMD ALISHSSKSY YACVGESTHA
     YQSPSKDLTA INNRLNGNRK VRGPLNFDDV DVGLVSDSMV ANSLYLQNGS SASSSGAPLK
     SEQPDS