ID   RBR1_TOBAC              Reviewed;         961 AA.
AC   Q9SXN6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Retinoblastoma-related protein 1;
DE            Short=NtRb1;
GN   Name=RB1;
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Sekine M.;
RT   "Tumor suppressor gene.";
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; AB015221; BAA76477.1; -; mRNA.
DR   RefSeq; NP_001312168.1; NM_001325239.1.
DR   AlphaFoldDB; Q9SXN6; -.
DR   SMR; Q9SXN6; -.
DR   STRING; 4097.Q9SXN6; -.
DR   GeneID; 107777437; -.
DR   KEGG; nta:107777437; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742; PTHR13742; 2.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..961
FT                   /note="Retinoblastoma-related protein 1"
FT                   /id="PRO_0000380242"
FT   REGION          404..819
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          404..606
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          607..728
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          729..819
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
FT   REGION          829..856
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   961 AA;  106603 MW;  0138DE06FC89ED2C CRC64;
     MVELNNCSNS EENGCVDSLE VRFTDFCKNG LSMGESFVTE ATKLFNDSKH LLLSNNSTIG
     VITEGVERYW FVFVLYSVKR LSEKEVGNSS NGNEGNAFSL CQILRGAKLN VVDFFKELPQ
     FILKVGPTLS NLYGSDWEKR LEAKELQTNF VHLSLLSKYY KRAYQELFLA SGNNEDKPSA
     TSSSAIHLPQ YYRFGWLLFL SLRIHVFSRF KDLVTCTNGL VSVLAILIIH VPVRFRNFNI
     NDSSRFVKKG DKVDLLASLG KIYQTSIDDL RETMDKVNYL ITEKLKKKPC LASEFRTENL
     DNLDTDGLTY FEDLMEESCL PSSVSILEKD YSDAIQNKGE LDERIFVNEE DSLLGSGSLS
     GGVVNMNGVK RKFDAMASPA KTVTSTLSPY RSPNCANSKM TVATPVSTAM TTARWLRTVI
     APLQPKPSAE LERFLSSCDR DVTADVIRRA QIILEAIFPS SGPAEHCAAG GSLQSTSLMD
     NIWAEQRTSE ALKLYYRVLQ TMCTAESQIL NGNNLTSLLT NERFHRCMLA CSAELVLATH
     KTVTMLFPAV LERTGITAFD LSKVIESFIR HEESLPRELR RHLNSLEERL LESMVWEKGS
     SMYNSLAVAK PSLAAEINRT GLLAEPMPSL DAIAMHINLS SGSLPPLPSL HKNNLAPNGQ
     IGDIRSPKKV CSEYRSVLVE RNSFTSPVKD RFLALNNIKS KFPPPALQSA FASPTRPNPG
     GGGETCAETA INVFFGKIVK LAAVRINGMI ERLQLSQQIR ETVYCLFQKI LSQRTSLFFN
     RHIDQIILCS FYGVAKRTGA DHVDIITFYN EMFIPSVKPL LVELAPAGNA EKNNHNDGQG
     PASPKPSPFP KLPDMSPKKV SAVHNVYVSP LRASKMDALI SHSSKSYYAC VGESTHAYQS
     PSKDLDVINN RLNGNRKLRG ALNFDVDAGL VSDSIVANSL YLQNGNCRSP VAHVKTEQPE
     S