ID   RBR1_WHEAT              Reviewed;         957 AA.
AC   A9UL13;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Retinoblastoma-related protein 1;
DE            Short=TaRBR1;
GN   Name=RBR1;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. CY-45;
RX   PubMed=17389586; DOI=10.1093/jxb/erm022;
RA   Lendvai A., Pettko-Szandtner A., Csordas-Toth E., Miskolczi P.,
RA   Horvath G.V., Gyoergyey J., Dudits D.;
RT   "Dicot and monocot plants differ in retinoblastoma-related protein
RT   subfamilies.";
RL   J. Exp. Bot. 58:1663-1675(2007).
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; AY941772; AAY23366.1; -; mRNA.
DR   AlphaFoldDB; A9UL13; -.
DR   SMR; A9UL13; -.
DR   STRING; 4565.Traes_7DS_B0D50DF2A.2; -.
DR   PRIDE; A9UL13; -.
DR   eggNOG; KOG1010; Eukaryota.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; A9UL13; baseline and differential.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:InterPro.
DR   GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR015030; RB_C.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   InterPro; IPR015652; RBR.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   PANTHER; PTHR13742:SF30; PTHR13742:SF30; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SMART; SM01369; Rb_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..957
FT                   /note="Retinoblastoma-related protein 1"
FT                   /id="PRO_0000380244"
FT   REGION          369..808
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          369..569
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          570..677
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          678..808
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
FT   REGION          814..854
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   957 AA;  106054 MW;  EDA72281FE439502 CRC64;
     MQLFKETKII LLSSMSSLGS GSPEEIERSW CACVLYCVSK LGNAGKAKED RGITLRQILR
     AFDLKIVDFF KEMPQFCIKV GFILTGLYGS DWEKRLELQE LQANLVHLCS LGRHYRRAYQ
     ELFLLNDGKP ANNSSELNVQ QASEYYDFGW LLFLVLRNQA SSAVKNLLTS TTELVSVLAV
     LIIHIPVRLR NFSIEDSSCF AKKSDKGVNL IASLCERYLT SEDELSKALQ KTNILIKDIL
     KKKPCSDVSE CQQGSLSFID PEGLTFFKNF LEEDSLKSSL QVLEKEYVNG LDTKGELDAR
     MFANEEDSLL GSGSLSGGAL KLPGTKRKYD DVMASPTKST ASRAPMSPPR FCPSPNGNSF
     CNSKMAPFTP VSTAMTTAKW LRSTISPLPS KPSGELLRFF SACDKDVTDD ITCRAAIILG
     AIFTGSSFGE RMCTSLRNTS GMDAIWTEQR KMEALKLYYR VLESMCRAES QILSGSNLTS
     LLSNERFHRC MIACSAELVL ATHKTVTMMF PAVLEKTGIT AFDLSKVIES FVRHEDSLPR
     ELKRHLNSLE ERLLESMAWE KGSSMYNSLI VARPTLSAEI NRLGLLAEPM PSLDAIAVHH
     DISLGGLPPL PFHKQPDKDE VRSPKRACTE RRNVLVDNSF RSPVKDAIKS KFLPPLQSAF
     ASPTRPNPAA GGETCAETGI GVFLSKITKL AAIRIKCLCE RLQLSQQILE RVYSLVQQII
     SQQTALFFNR HIDQIILCCI YGVAKISQLA LTFKEIIFSY RKQSQCKPQV FRSVYVNWPS
     RSRSGKIGED HVDIITFYNE VFIPTVKPLL VDLGPGTSPN RNNEPKSGGD AASFPESPRL
     SRFPNLPDMS PKKVSATHNV YVSPLRSSKM DTLLSPSSKS YYACVGESTH AFQSPSKDLN
     AINTRLNSGK KVNGRLNFDV VSDLVVARSL SDQNGSSAAA MAVFGTKTPV KGEQQDP