RBR2_MAIZE
ID RBR2_MAIZE Reviewed; 866 AA.
AC Q8H0J6; O22345; O22346;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Retinoblastoma-related protein 2;
DE Short=ZmRBR2;
GN Name=RBR2; Synonyms=RRB2;
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Plasencia J., Najera-Martinez M., Vazquez-Ramos J.M., Ramirez-Parra E.,
RA Gutierrez C.;
RT "Molecular cloning and characterization of a maize retinoblastoma-related
RT gene.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 256-866 (ISOFORMS 1 AND 2), TISSUE
RP SPECIFICITY, AND ALTERNATIVE SPLICING.
RC STRAIN=cv. B73;
RX PubMed=9271385; DOI=10.1128/mcb.17.9.5077;
RA Ach R.A., Durfee T., Miller A.B., Taranto P., Hanley-Bowdoin L.,
RA Zambryski P.C., Gruissem W.;
RT "RRB1 and RRB2 encode maize retinoblastoma-related proteins that interact
RT with a plant D-type cyclin and geminivirus replication protein.";
RL Mol. Cell. Biol. 17:5077-5086(1997).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17389586; DOI=10.1093/jxb/erm022;
RA Lendvai A., Pettko-Szandtner A., Csordas-Toth E., Miskolczi P.,
RA Horvath G.V., Gyoergyey J., Dudits D.;
RT "Dicot and monocot plants differ in retinoblastoma-related protein
RT subfamilies.";
RL J. Exp. Bot. 58:1663-1675(2007).
CC -!- FUNCTION: Regulator of biological processes that recruits a histone
CC deacetylase to control gene transcription. May play a role in the entry
CC into mitosis, negatively regulating the cell proliferation. Formation
CC of stable complexes with geminiviridae replication-associated proteins
CC may create a cellular environment which favors viral DNA replication
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=2a;
CC IsoId=Q8H0J6-1; Sequence=Displayed;
CC Name=2; Synonyms=2b;
CC IsoId=Q8H0J6-2; Sequence=VSP_033764, VSP_033765;
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9271385}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000305}.
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DR EMBL; AJ279062; CAC82493.1; -; Genomic_DNA.
DR EMBL; AF007795; AAB69651.1; -; mRNA.
DR EMBL; AF007794; AAB69650.1; -; mRNA.
DR PIR; T01172; T01172.
DR PIR; T01173; T01173.
DR AlphaFoldDB; Q8H0J6; -.
DR SMR; Q8H0J6; -.
DR STRING; 4577.GRMZM2G153150_P01; -.
DR PaxDb; Q8H0J6; -.
DR PRIDE; Q8H0J6; -.
DR MaizeGDB; 273693; -.
DR eggNOG; KOG1010; Eukaryota.
DR Proteomes; UP000007305; Unplaced.
DR ExpressionAtlas; Q8H0J6; baseline and differential.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:InterPro.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR InterPro; IPR015652; RBR.
DR PANTHER; PTHR13742; PTHR13742; 1.
DR PANTHER; PTHR13742:SF22; PTHR13742:SF22; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell cycle; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..866
FT /note="Retinoblastoma-related protein 2"
FT /id="PRO_0000335247"
FT REGION 274..721
FT /note="Pocket"
FT REGION 274..475
FT /note="Domain A"
FT REGION 476..593
FT /note="Spacer"
FT REGION 513..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..721
FT /note="Domain B"
FT REGION 731..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..537
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 839..854
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 832..839
FT /note="SDSVVAGS -> CLMLTLLL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9271385"
FT /id="VSP_033764"
FT VAR_SEQ 840..866
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:9271385"
FT /id="VSP_033765"
FT CONFLICT 266
FT /note="C -> G (in Ref. 2; AAB69651)"
FT /evidence="ECO:0000305"
FT CONFLICT 314
FT /note="Y -> N (in Ref. 2; AAB69651)"
FT /evidence="ECO:0000305"
FT CONFLICT 403..404
FT /note="DV -> EL (in Ref. 2; AAB69651)"
FT /evidence="ECO:0000305"
FT CONFLICT 423
FT /note="A -> T (in Ref. 2; AAB69651)"
FT /evidence="ECO:0000305"
FT CONFLICT 544
FT /note="P -> T (in Ref. 2; AAB69650/AAB69651)"
FT /evidence="ECO:0000305"
FT CONFLICT 647..648
FT /note="ID -> MH (in Ref. 2; AAB69650/AAB69651)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 866 AA; 96532 MW; 433DF3024515E16C CRC64;
MSSQDPPPAT STQKKQSESL VNLLAEASRF YRKAYNELFS GLITEWEPES STNIPDYMLF
GWHLFLNLRL RSPELFKDLV SCIHGLVAVL AILLVHVPAK FRTFTIEGSS HLIKQTEKGV
DLIASLCHNY HTSEECLKEM MDKSHKAIEE VFSMKALSAS ECKTENLDKI DTDRLMYFKG
LIDMECFQSN LEKIEKLCNS NNCEAELDFK LILTNNDYIP CAENLSRDST NLGCSKCAFE
TLASPRKTIK NMLTVPSSPL SPTNGCSVKI VQMTPITSAM TTAKWLREVI SSLPEKPSSK
LQQLMSSCDR DLTYAVTERV SIVLEAIFPT KSSADRGGSL GLNCANAFDT LWADARKMEA
SKLYYRVLEA ICRAELQNSN VNNLTPLLSN ERFHRCLIAC SADVVLATHK TVIMMFPAVL
ESAGLTSFDL SKIIENFVRH EETLPRELKR HLNSLEEQIL ESMAWEKGSS LYNSLIVARP
SVASEINRFG LLAESMPSLD DLVARQNIHI EGLPATPSKK RAAGRDDNAD PRSPKRPCNE
SRSPVVEHNL QTPPPKQCHM VLTSLKAKCH PLQSTFASPT VSNPVGGNEK CADVTIQIFF
SKILKLAAIR IRNLCERIQY MEQTERVYNV FKQILDQQTT LFFNRHIDQL ILCCLYGVAK
VCQLELSFRE ILNNYKKEAQ CKPEVFLSIY IGSRNHNGVL ISRHVDIITF YNEVFVPAAK
PFLVSLISSG TRPEDKKNAS GQVPGSPKLS PFPNLPDMSP KKVSASHNVY VSPLRQTKMD
LLLSPSSRSF YACIGEGTHA YQSPSKDLAA INSRLNYNGR RVNSRLNFDM VSDSVVAGSL
GQPNGGSTSL DPAAAFSPLS KRKPDT
