RBR2_ORYSJ
ID RBR2_ORYSJ Reviewed; 978 AA.
AC Q2R374; A0A0P0Y3E4; A3CBY4; A9UL16; B7EAB3; Q2R375;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Retinoblastoma-related protein 2;
DE Short=OsRBR2;
GN Name=RBR2; OrderedLocusNames=Os11g0533500, LOC_Os11g32900;
GN ORFNames=OsJ_34123;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Taipei 309;
RX PubMed=17389586; DOI=10.1093/jxb/erm022;
RA Lendvai A., Pettko-Szandtner A., Csordas-Toth E., Miskolczi P.,
RA Horvath G.V., Gyoergyey J., Dudits D.;
RT "Dicot and monocot plants differ in retinoblastoma-related protein
RT subfamilies.";
RL J. Exp. Bot. 58:1663-1675(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG The rice chromosomes 11 and 12 sequencing consortia;
RT "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT genes and recent gene duplications.";
RL BMC Biol. 3:20-20(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: Regulator of biological processes that recruits a histone
CC deacetylase to control gene transcription. May play a role in the entry
CC into mitosis, negatively regulating the cell proliferation. Formation
CC of stable complexes with geminiviridae replication-associated proteins
CC may create a cellular environment which favors viral DNA replication
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2R374-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2R374-2; Sequence=VSP_033766, VSP_033767;
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000305}.
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DR EMBL; AY941775; AAY23369.1; -; mRNA.
DR EMBL; DP000010; ABA94065.2; -; Genomic_DNA.
DR EMBL; DP000010; ABA94066.2; -; Genomic_DNA.
DR EMBL; AP008217; BAF28383.1; -; Genomic_DNA.
DR EMBL; AP014967; BAT14296.1; -; Genomic_DNA.
DR EMBL; CM000148; EEE52218.1; -; Genomic_DNA.
DR EMBL; AK064987; BAG89310.1; -; mRNA.
DR RefSeq; XP_015617546.1; XM_015762060.1. [Q2R374-1]
DR AlphaFoldDB; Q2R374; -.
DR SMR; Q2R374; -.
DR STRING; 4530.OS11T0533500-01; -.
DR iPTMnet; Q2R374; -.
DR PaxDb; Q2R374; -.
DR PRIDE; Q2R374; -.
DR EnsemblPlants; Os11t0533500-01; Os11t0533500-01; Os11g0533500. [Q2R374-1]
DR EnsemblPlants; Os11t0533500-02; Os11t0533500-02; Os11g0533500. [Q2R374-1]
DR GeneID; 4350648; -.
DR Gramene; Os11t0533500-01; Os11t0533500-01; Os11g0533500. [Q2R374-1]
DR Gramene; Os11t0533500-02; Os11t0533500-02; Os11g0533500. [Q2R374-1]
DR KEGG; osa:4350648; -.
DR eggNOG; KOG1010; Eukaryota.
DR HOGENOM; CLU_015949_0_0_1; -.
DR InParanoid; Q2R374; -.
DR OMA; DYIRFGW; -.
DR OrthoDB; 113612at2759; -.
DR PlantReactome; R-OSA-9640887; G1/S transition.
DR Proteomes; UP000000763; Chromosome 11.
DR Proteomes; UP000007752; Chromosome 11.
DR Proteomes; UP000059680; Chromosome 11.
DR Genevisible; Q2R374; OS.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:InterPro.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR InterPro; IPR015652; RBR.
DR PANTHER; PTHR13742; PTHR13742; 1.
DR PANTHER; PTHR13742:SF22; PTHR13742:SF22; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR Pfam; PF08934; Rb_C; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell cycle; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..978
FT /note="Retinoblastoma-related protein 2"
FT /id="PRO_0000335251"
FT REGION 385..832
FT /note="Pocket"
FT REGION 385..585
FT /note="Domain A"
FT REGION 586..704
FT /note="Spacer"
FT REGION 616..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 705..832
FT /note="Domain B"
FT REGION 841..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 843..878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 853..873
FT /note="QIPGSPKSSPFSNLPDMSPKK -> ISSILFSQFKPANSPLNSSYN (in
FT isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_033766"
FT VAR_SEQ 874..978
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_033767"
FT CONFLICT 28
FT /note="G -> C (in Ref. 1; AAY23369)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="K -> R (in Ref. 1; AAY23369)"
FT /evidence="ECO:0000305"
FT CONFLICT 104
FT /note="A -> V (in Ref. 1; AAY23369)"
FT /evidence="ECO:0000305"
FT CONFLICT 128
FT /note="L -> S (in Ref. 1; AAY23369)"
FT /evidence="ECO:0000305"
FT CONFLICT 420..421
FT /note="DT -> NM (in Ref. 1; AAY23369)"
FT /evidence="ECO:0000305"
FT CONFLICT 631
FT /note="W -> R (in Ref. 1; AAY23369)"
FT /evidence="ECO:0000305"
FT CONFLICT 659
FT /note="R -> H (in Ref. 1; AAY23369)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 978 AA; 107865 MW; 6AF472B09E2F50B0 CRC64;
MASQPPAAVE ARLADLCKEL GVDEGVAGEA AAVLEEGKGA LLASPSFGSK SPEDAEKLCF
AFVLYCVSKL KETKAGSSGV RLWEILKGCK LKYDDFFKES QRLASRIDQV LGSRYGSDWE
ARLELKQLEN LVNLLADASR FYCKAFNELF LSPSTDQEPG STTNIPDYIR FGWLLFLILR
SKSPELFKDL VSCIHGLVAI LAILLIHVPA KFRSFTIEGS SHLIKQTEKG VDLLPSLCHN
YHTSEDRLKE MMGKSYKVIE VFFSRKAINA SEFKTVNLDK IDTDGLMYFK DLVDDEIFQS
NLEKLEKLSS TTGCQGELDL EMFLTSNDYV LNAENSSGSS ANFGCSKRVF ETLASPTKTI
KNMLAAPSSP SSPANGGSIK IVQMTPVTSA MTTAKWLRDV ISSLPDKPSS KLEEFLSSCD
TDLTSDVVKR VSIILEAIFP TKSIDRGTSI GLNCANAFDI PWAEARKMEA SKLYYRVLEA
ICRAESQNNN VNNLTPLLSN ERFHRCLIAC SAELVLATHK TVIMMFPAVL ESTGLTAFDL
SKIIENFVRH EETLPRELKR HLNSLEEQLL ESMSWEKGSS LYNSLVVARP SLSTEINSLG
LLAEPMPSLD GIVARQSIHP DGLPPTPSKR WPSAGPDGNC YPQSPKRLCT ESRNSLVERN
SQTPPPKQSQ TGLSILKAKY HPLQATFASP TVSNPVSGNE KCAVVGVQIF FSKILKLAAI
RIRNLCERLR HEELTVSVYN IFKQILDQQT ALFFNRHVDQ IILCCLYGVA KVSQLSLTFK
EIVNNYKREP QCKPEVFRSI FVGSTNRNGG FGSRHVDIIV FYNQVFVPTV KPLLVALMPS
STRPEDKRNT NSQIPGSPKS SPFSNLPDMS PKKVSSSHNV YVSPLRQTKM DALLSPSSRS
FYACIGESTQ AFQSPSKDLA AINSRLNYPT RRINTRINFD MVSDSVVAGS LGQPNGGSAS
SDPAAAFSPL SKKSKTDS
