RBR3_MAIZE
ID RBR3_MAIZE Reviewed; 1010 AA.
AC Q3LXA7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Retinoblastoma-related protein 3;
DE Short=ZmRBR3;
GN Name=RBR3;
OS Zea mays (Maize).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea.
OX NCBI_TaxID=4577;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16141340; DOI=10.1073/pnas.0506160102;
RA Sabelli P.A., Dante R.A., Leiva-Neto J.T., Jung R., Gordon-Kamm W.J.,
RA Larkins B.A.;
RT "RBR3, a member of the retinoblastoma-related family from maize, is
RT regulated by the RBR1/E2F pathway.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13005-13012(2005).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=17389586; DOI=10.1093/jxb/erm022;
RA Lendvai A., Pettko-Szandtner A., Csordas-Toth E., Miskolczi P.,
RA Horvath G.V., Gyoergyey J., Dudits D.;
RT "Dicot and monocot plants differ in retinoblastoma-related protein
RT subfamilies.";
RL J. Exp. Bot. 58:1663-1675(2007).
CC -!- FUNCTION: Regulator of biological processes that recruits a histone
CC deacetylase to control gene transcription. May play a role in the entry
CC into mitosis, negatively regulating the cell proliferation. Formation
CC of stable complexes with geminiviridae replication-associated proteins
CC may create a cellular environment which favors viral DNA replication
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000305}.
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DR EMBL; DQ124423; AAZ99092.1; -; mRNA.
DR RefSeq; NP_001105822.1; NM_001112352.1.
DR RefSeq; XP_008649201.1; XM_008650979.1.
DR RefSeq; XP_008649206.1; XM_008650984.1.
DR AlphaFoldDB; Q3LXA7; -.
DR SMR; Q3LXA7; -.
DR STRING; 4577.GRMZM2G033828_P02; -.
DR PaxDb; Q3LXA7; -.
DR PRIDE; Q3LXA7; -.
DR EnsemblPlants; Zm00001eb037120_T001; Zm00001eb037120_P001; Zm00001eb037120.
DR GeneID; 732723; -.
DR Gramene; Zm00001eb037120_T001; Zm00001eb037120_P001; Zm00001eb037120.
DR KEGG; zma:732723; -.
DR MaizeGDB; 1203650; -.
DR eggNOG; KOG1010; Eukaryota.
DR OrthoDB; 113612at2759; -.
DR Proteomes; UP000007305; Chromosome 1.
DR ExpressionAtlas; Q3LXA7; baseline and differential.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:InterPro.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR InterPro; IPR015652; RBR.
DR PANTHER; PTHR13742; PTHR13742; 1.
DR PANTHER; PTHR13742:SF30; PTHR13742:SF30; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Cell cycle; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1010
FT /note="Retinoblastoma-related protein 3"
FT /id="PRO_0000335248"
FT REGION 416..858
FT /note="Pocket"
FT REGION 416..616
FT /note="Domain A"
FT REGION 617..727
FT /note="Spacer"
FT REGION 728..858
FT /note="Domain B"
FT REGION 867..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 986..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1010 AA; 111494 MW; 0027146630017F6D CRC64;
MEGFAKPSTS SGSGVTVRAS VAAASIEERF ADLCKAKLGL DESTTRQAMQ LLKETNNILK
SSMSSLGGGS PEEIERFWSA CVLYCVSRLS KAGRSKEDGS VSLCQILRAS KLNIVDFFKE
MPQFCIKVAH ILTGLYGSDW EKRLELKELQ ANVVHLSLLS SYYKRAYQEL FLSNDGKSSD
NSSESNNQEA SDYYRFGWLL FLVLRIQTFS RFKDLVTSTN ELVSVLAVLI IHVPVRLRNF
DIKDSSYFGK KSDRGVSLIA SLCEKHHTSE DELSKALEKT NTLIMDILKK KPCPATSACQ
QDNLSFIDPE GLTVFKDLLQ GDSLKPSLII LEKEYENAIN TKGELDERMF ANDEDSLLGS
GSLSGGAINL PGTKRKYDVM ASPAKSISSP NPMSPPRFCL SPKGNGFCNS KMAPSTPVST
AMTTAKWLRN TVSPLPSRPS GELLRFFSAC DKDLTDDIAH RAGIILGAIF TSSSFGERIC
TSMRSASRMD AIWTEQRKME ALKLYYRVLE SMCRAESQIL SGNNLTSLLS NERFHRCMIA
CSAELVLATH KTVTMMFPAV LEKTGITAFD LSKVIEGFVR HEDTLPRELK RHLNSLEERL
LESMAWEKGS SMYNSLIVAR PALSVEISRL GLLAEPMPSL DAIAAHHNIS LGGLPPLPFQ
KQERLQDKDE VRSPKRACTE RRNVLVDSNS LRSPVKDIIK PKLPPLQSAF ASPTRPNPAA
GGETCAETGI GVFFSKISKL AAIRIRSLCE RLQLPQQVLE RVYSLVQQIL SQQTGLFFNR
HIDQIILCSI YGVAKISQLE LSFKEIIFGY RKQPQCKPQV FRSVYVHWPP RSRNGKTGED
HVDIITFYNE VFIPAVKSLL VEVGPGASAS PKKKEEEKGP ADVGPFPESP RLARFPNLPD
MSPKKVSATH NVYVSPLRSS KMDTLLSPSS KSYYACVGES TYAFQSPSKD LKAINNRLNS
VSGGKKVSGR LNFDVVSDLV VASSLGSDRD AKPAADPAKT TPVKCEPSDS
