ID   RBR_CAMSI               Reviewed;        1025 AA.
AC   Q2ABE5;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Retinoblastoma-related protein;
GN   Name=pRB;
OS   Camellia sinensis (Tea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; Ericales; Theaceae; Camellia.
OX   NCBI_TaxID=4442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Leaf;
RA   Fukamizu T., Shoyama Y., Sasaki K., Taura F., Shoyama Y., Morimoto S.;
RT   "Studies on cell cycle in Camellia sinensis.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; AB247284; BAE80326.1; -; mRNA.
DR   AlphaFoldDB; Q2ABE5; -.
DR   SMR; Q2ABE5; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1025
FT                   /note="Retinoblastoma-related protein"
FT                   /id="PRO_0000380230"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          422..875
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          422..623
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          624..744
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          745..875
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1025 AA;  113116 MW;  57343736ED9A70FD CRC64;
     MEDHPPKPSI PTADASLSNH GRGGPSLDAR FAYFCKTGLS LNENTYTEAM KLFSESKHLL
     STTISAIGTG TPEEAERYWF AFVLYSVKRL SEANADDSSQ GTGGDGFTLC QILRVAKLNI
     VDFFKELPQF IVKAGPILSN QYGTDWEKRL EAKELQANFV HLSLLSKYYK RAFREFFLTS
     DAKVGEQSTA AIASGYVSDY HRFGWLLFLA LRTHAFSRFK DLVTCTNGLV AILAILIIHI
     PVRVRNFNLH DSPRFVMKGS KGVDLLASLC NIYETSEDEL RKTMEKANDL IEDILKKNRR
     SASECRSENL ENIATDGLIY FEDLLDDTSL PSSLNILGKD YADATRNKGE LDERVFVNEE
     DSLLGPGSLS GGAMNISGAK RKIDSIASPA RTITSPLAPY CSPSASHAKA IPCGSNSKMA
     ATPVTTAMTT AKWLRTIISP LPPKPSPELE RFLSSCDSDV TTDVIRRANI ILEAIFPSSG
     LGEECITGGL QCTSLMDSIW AEQRRLEALK LYYRVLQAMC TAEAQILHAN NLTSLLTNER
     FHRCMLACSA ELVLATHKTA TMLFPAVLER TGITAFDLSK MIGVSFRLKE SLPRELKRHL
     NSLEERLLES MVWEKGSSMY NSLTVARPAL SAETNRLCLL AEPMPSLDAI AMHMNITCGS
     LPCLPSLQKN EILLGQNGDI QSPKRLCTEY RSVLVERNSF TSPVKDRLLT FNTPKSKLPP
     PALQSAFASP TRPNPGAGGE TCAETAINVF FSKIVKLGAF RINGMVERLQ LSQEIREIIF
     RLFQQILSQR TTLFFNRHID QIILCCFYGV AKISQLSLTF KEIISTIESN PQCKPQVFRS
     VFVDWSSARR HGKTGQEHVD IITFYNEIFI PAVKPLLVEL APVGTAQKNR NSETINGTDG
     QCPGSPKISP FPSLPDMSPK KVSAIHNVYV SPLRSSKMDA LISNGSKSYY ACVGESTHAY
     QSLSKDLTAI NNRLNGNRKL RGTLNFDEVD VGLVSDTLVA NSLWLQNGSC ASSSGAPVKS
     ERLDS