ID   RBR_COCNU               Reviewed;        1011 AA.
AC   Q8H252;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Retinoblastoma-related protein;
GN   Name=Rb1;
OS   Cocos nucifera (Coconut palm).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Arecaceae; Arecoideae; Cocoseae;
OC   Attaleinae; Cocos.
OX   NCBI_TaxID=13894;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Malayan Yellow Dwarf; TISSUE=Shoot meristem;
RA   Hocher V.R., Sandoval Esquivez A., Farinas B.T., Tregear J.W., Morcillo F.,
RA   Verdeil J.-L.;
RT   "A coconut cDNA encoding a member of the retinoblastoma protein family:
RT   Characterization of its expression in tissues showing different
RT   meristematic capacity.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY117036; AAM77469.1; -; mRNA.
DR   AlphaFoldDB; Q8H252; -.
DR   SMR; Q8H252; -.
DR   PRIDE; Q8H252; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:InterPro.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR015030; RB_C.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   InterPro; IPR015652; RBR.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   PANTHER; PTHR13742:SF30; PTHR13742:SF30; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SMART; SM01369; Rb_C; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1011
FT                   /note="Retinoblastoma-related protein"
FT                   /id="PRO_0000380232"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          411..860
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          411..612
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          613..729
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          730..860
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
FT   REGION          872..903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        874..893
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1011 AA;  112253 MW;  B445CB70D4407095 CRC64;
     MSQASVDMED VKPSISLPSD DGGAMEARLT DVCKSKLALD ESTMRQAMIL FRESKHILLA
     NMSAIGSGSP EEIERFWSAF VLYCVTRLSK GRTKQEKEEN GITLCRILRV LKMNVVDFFK
     EIPQFCLKAG YILTGLYGSD WEKRLELKEL QANIVHLSLL SRYYKRAYQE LFLPNDASSG
     RHSVAPNSVG YVSDYHHFGW LLFLALRIHA FSRFKDLVTC TNGLVSILAI LILHIPARFR
     NFHIQDSLLF AKRTAKGVDL VASLCDKYHT SEDELRRVME KANNLIVDIL KKKPCAASEC
     KRENLAYINT DGLIYFEDLL EENSLQSSIL ILEDNYDDAI NSKGELDERM FVNDEDSLLG
     SGSLSGGSIK MKRKYDAMAS PAKSITSPLS PPLSPASPVN GNPVIKMVPI TPVSTAMTTA
     KWLRNIISPL PSRPSTELLC FFSSCDRDIT TDVTRRASII LGAIFPTTSF GDCCISGNLQ
     SVNQMDSIWA EQRKVEAMKL YYRVLETMCR AESHILNGNN LTSLLSNDRF HRCMLACSAE
     LVLATHKTVT MMFPAVLEKT GITAFDLSKV IESFVRHEET LPRELKRHLN SLEERLLESM
     AWERGSSMYN SLIVARPTLA AEINRLGLLA EPMPSLDAIA VHNNISTGGL PPLPFQKHEH
     SSDQNGGAVS PKRACSEYRS VLVERNSFTS PVKELTLTLN LKSKLPPLQS AFASPTRPNP
     AGGGETCAET GINIFFNKIV KLAAIRIRSL CERLQLPQQI LEWVYCLIQQ ILSQRTALFF
     NRHIDQIILC SFYGVAKISQ MALTFKEIIY NYRKQPQCKP QVFRSVFVHW PSTSHNGKTG
     QEHVDIITFY NEVFIPSVKP LLVELGPAGV AQKSKSSPED SNNADSQIPG SPRLSPFPNL
     PDMSPKKVSA AHNVYVSPLR SSKMDALLSP SSKSYYACVG ESTHAYQSPS KDLTAINNRL
     NSGRKVSGRL NFDVVSDSVV AGSLGAQNGS SAPAPACSIL ELPVKREQPD S