ID   RBR_HIEPI               Reviewed;        1005 AA.
AC   B1ABR6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Retinoblastoma-related protein;
GN   Name=RBR;
OS   Hieracium piloselloides (King devil hawkweed).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC   Hieraciinae; Hieracium.
OX   NCBI_TaxID=102746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. D3; TISSUE=Ovary;
RX   PubMed=18812497; DOI=10.1105/tpc.108.059287;
RA   Rodrigues J.C.M., Tucker M.R., Johnson S.D., Hrmova M., Koltunow A.M.G.;
RT   "Sexual and apomictic seed formation in Hieracium requires the plant
RT   polycomb-group gene FERTILIZATION INDEPENDENT ENDOSPERM.";
RL   Plant Cell 20:2372-2386(2008).
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; EU439049; ABZ85628.1; -; mRNA.
DR   AlphaFoldDB; B1ABR6; -.
DR   SMR; B1ABR6; -.
DR   IntAct; B1ABR6; 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1005
FT                   /note="Retinoblastoma-related protein"
FT                   /id="PRO_0000380233"
FT   REGION          404..853
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          404..605
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          606..722
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          723..853
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
FT   REGION          863..899
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        863..877
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1005 AA;  112636 MW;  C1B1FDE0CF5CBFD7 CRC64;
     MEDLQPINPN TDSPTETGAT TIEARFSYFC KGRLTMDDNA LEEAMKLFNQ SKHLFMTNAS
     ALGSGTPEEA EHYWFAFILF SMKRLSKKND AEDAAKSNEN SFKLYQILRV AKLNFVDFFK
     ELPQFIVKTG PILSNLYGSD WETRLQAKEL QANFVHLSLL SKYYKRAFKT LFKPSHDNVE
     GQSAVANSAD YISNCHRFGW LLFLALRVHA FSRFKDLVTC TNGLVSILAI LIIHIPARFR
     NFSMSDSSHF VKKDDKVVDL LASLCNMYET SEDELRKTMV RTNIVVEEIL KKDPSMASEC
     TNGNLDNIDT DDLTYFQDLL EEQSLSSDLD ILEKDYDDAM LLEGELDERL FINDEESLLG
     SSSLSGGAIN MTGTKRKIDS MTSPTKTITS PLSPYKSPSK MISTPVSTAM TTAKWLRTVV
     SPLSSFPSVD LTRFLQSCDK DVTSDVIKRA RIILEAIFPS SGIPDRTVLS NTQTTNLMDN
     IWAEQRRLEA LKLYYRVLHA MCKAESQILH GNNLTSLLTN ERFHRCMLAC SAELVLATHK
     TVTMLFPAVL ERTGITAFDL SKVIESFIRH EESLPRELRR HLNSLEERLL ESMVWEKGSS
     MYNSLTIARP NLSNEINRLG LLAGPMPSLD AIALQCNMSC GGLPPVPKRD TSPGKSGEIR
     SPKRVCNEYR SVLVERNSFT SPVKDRLLGI GNLKSKILSP ALQSAFASPT RPHPTRGETC
     AETAVNLFFS KIVKLAAVRI NGMVERMQLT QQIRERVYCL FQQILGQRTS LFFNRHIDQI
     ILCCFYGVAK ITQLSLTFKE IIFNYRKQPH CKPQVFRAVF VDDRSSSRRG KTGQDHVDII
     MFYNEIFIPS VKPLLVELAP SNVPKNPNNQ VSETNKKDES GPCPCPGSPK VSSFPSLPDM
     SPKKVSAVHN VYVSPLRSTK MDALISHGSK SYYACVGEST HAYQSPSKDL TAINNRLNGT
     RKVRGSLNFD EVDVGLVSDS LVSQSLYLQN GKGPASSSGQ ELKTE