ID   RBR_MEDSA               Reviewed;        1025 AA.
AC   A9UL14;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Retinoblastoma-related protein;
DE            Short=MsRBR;
GN   Name=RBR;
OS   Medicago sativa (Alfalfa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX   NCBI_TaxID=3879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Varia;
RX   PubMed=17389586; DOI=10.1093/jxb/erm022;
RA   Lendvai A., Pettko-Szandtner A., Csordas-Toth E., Miskolczi P.,
RA   Horvath G.V., Gyoergyey J., Dudits D.;
RT   "Dicot and monocot plants differ in retinoblastoma-related protein
RT   subfamilies.";
RL   J. Exp. Bot. 58:1663-1675(2007).
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; AY941773; AAY23367.1; -; mRNA.
DR   AlphaFoldDB; A9UL14; -.
DR   SMR; A9UL14; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   CDD; cd00043; CYCLIN; 1.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1025
FT                   /note="Retinoblastoma-related protein"
FT                   /id="PRO_0000380235"
FT   REGION          388..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..871
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          415..615
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          616..736
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          737..871
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
FT   REGION          885..912
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1006..1025
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        886..902
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1025 AA;  114198 MW;  A3B7094BF1FF6C1E CRC64;
     MSPSTETEME DTKPSVVENG DQAVSRFAEF SKNELALDEK SCKEAMDLFG ETKHLLMANV
     SSMGNGTIEE AERYWFAFIL YSIKRLTQKN EESEKEEIEN TGLTLCRILR AAKLNIADFF
     KELPQFVVKA GPILSNRFGS DWENKLEAKE MHANTIHLKI LSKYYKRVFE EFFVSTDANV
     ENESSVTGRV SECHRFGWLL FLALRVHAFS RFKDLVTCTN GLISIMAILI IHVPARFRNF
     NIQDSARFVK KSSKGVDLLA SLCNIYNTSE DELRKTMEQA NNLVADILKK TPCLASECET
     ENLEDFDKDG LTYFKDLMEE SSLASSLNIL ENDYDQMTRN KGELDERLFI NEDDSLLASG
     SLSGGSSVSA GGVKRKYDLM MSPSKTIISP LSPQRSPASH ANGIPGSTNS KIAATPVSTA
     MTTAKWLRTV ISPLPSKPSQ ELERFLTSCD RDITSEVVRR AQIILQAIFP SSPLGDRCVT
     GSLQSANLMD NIWAEQRRLE AMKLYYRLLA TMCRAEAQIL GNNLTSLLTN ERFHRCMLAC
     SAELVLATHK TVTMLFPAVL ERTGITAFDL SKVIESFIRY EESLPRELRR HLNSLEERLL
     ESLVWEKGSS MYNSLAVARP ALSAEINRLS MLAEPMPSLD EIAMHINFSC GGLPPVPSLP
     KPETLPAQNG DMRSPKRLCT ENRNVLAERN SFTSPVKDRL LHLSNLKSKL LPPPLQSAFA
     SPTKPNPGGG GETCAETGIS VFFSKIVKLG AVRISGMVER LQLSQQTREN VYSLFQRILN
     QRTSLFFNRH IDQIILCCFY GVAKISQLNL TFREIIYNYR KQPQCKPQVF RSVFVDWSPA
     RRNGGARHRT GQEHIDIISF YNEVFIPSVK PLLVELGPGG ATVRSDQVPE ANSKTDGHLV
     QNPGSPRISP FPSLPDMSPK KVSAAHNVYV SPLRSSKMDA LISHSSKSYY ACVGESTHAY
     QSPSKDLTAI NNRLNSNRKV RGPLKFDDVD VGLVSDSMVA NSLYLQNGSS ASSSGAPLKS
     EQPDS