ID   RBR_OXYRB               Reviewed;        1012 AA.
AC   O82677;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Retinoblastoma-related protein;
GN   Name=RB;
OS   Oxybasis rubra (Red goosefoot) (Chenopodium rubrum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Chenopodiaceae; Chenopodioideae; Atripliceae; Oxybasis.
OX   NCBI_TaxID=3560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hypocotyl;
RA   Fountain M.D., Murray J.A.H., Beck E.;
RT   "Isolation of a full-length cDNA encoding a retinoblastoma protein from
RT   suspension cultured photoautotrophic Chenopodium rubrum L. cells.";
RL   (er) Plant Gene Register PGR99-003(1999).
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; AJ011681; CAA09736.1; -; mRNA.
DR   PIR; T43054; T43054.
DR   AlphaFoldDB; O82677; -.
DR   SMR; O82677; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1012
FT                   /note="Retinoblastoma-related protein"
FT                   /id="PRO_0000380231"
FT   REGION          403..863
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          403..604
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          605..723
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          724..863
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
FT   REGION          884..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        887..901
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1012 AA;  112991 MW;  5FB16EE0829AAEC9 CRC64;
     MKMEDLFSLL PWLRDVPVQN QFSLDDKMYS DALKLFTESK SILSNNVSPI GSTTPEELER
     YMFAFILYAS KRLGAKTTGD ASEGSNQSGI TLCQKLKAVK LNLVDFFKEL PQFVVKIGPI
     LSDMYGADWE KRLEAKELQA NFVHLSLLSK YYKRAYQEFF KTNEVDKEVA DPGTSSSDSI
     SDYYRFGWLL FLALRVHAFS RFKDLVTCTN GIVSVLAILI IHIPARLRKF SALDLPLFEK
     KIDRGVNLVA SLCQKYDTSE DEVKHMMEKA NELILEILKK NPCSASLCKT ENLENIDPDD
     LTYFEDLLED SSLPNCISML EKDYDAAIWN KGDIDERVFV NVDDSLLGSG SLSGGAINIS
     GLREIRCNGL FNETIASPLS PCRSPALHVN GARGGVNIRM ISTPVSTAMT TAKWLRTYIS
     PLPSKPSPQL EKYLMSCDRN ISSEVVRRAH IIMEAIFPNS ALGERCIAGS LPNSNLTDNI
     WAQQRRLEAL KLYYRVLETM CTAEAQLLHA NNLTSLLTNE RFHRCMLACS AELVLATHKT
     VTMLFPAVLE KTGITAFDLS KVIESFIRHE DSLPRELRRH LNSLEERLLE SMAWEKGSSM
     DNSLIIARPA LSAGINRFGL LAEPMPFLNA MAAHIEVSTG GLPPLPSSCK HEFAAGQNGD
     IRSPKRACTE YRSVLVERNS FTSPVKDRLI NNLKQKLTPP ALQSAFASPT RLSPGGGGET
     CAETGINIFF SKIVKLAAVR INGMIERLEK LEKQSQTQQL REQLRENVYC RFHIILNQRT
     SLFFNRHIDQ IILCAFYGVA KISQYELTFK EIILNYRKQP QCKPQVFRSV FVDWSFSRRN
     RQGQDHVDII TFYNEVFIPS VKPLLGELGP QGACVKTDLI PESNNDKDGQ CPGSPKLSTF
     PSLPDMSPKK VAKNVYVSPL RSSKMDALIS NSSKSYYACV GESTHAFQSP SKDLTAINDR
     LNSTSKVRGA LNFDTDAGLV SDSLVANSLY LQNGNCATTS SVGPLKTEQP DS