RBR_PHYPA
ID RBR_PHYPA Reviewed; 1116 AA.
AC A9SVH7;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Retinoblastoma-related protein;
GN Name=RBR; Synonyms=RBL1501; ORFNames=PHYPADRAFT_84532;
OS Physcomitrium patens (Spreading-leaved earth moss) (Physcomitrella patens).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Bryophyta;
OC Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrium.
OX NCBI_TaxID=3218;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Gransden 2004;
RX PubMed=18079367; DOI=10.1126/science.1150646;
RA Rensing S.A., Lang D., Zimmer A.D., Terry A., Salamov A., Shapiro H.,
RA Nishiyama T., Perroud P.-F., Lindquist E.A., Kamisugi Y., Tanahashi T.,
RA Sakakibara K., Fujita T., Oishi K., Shin-I T., Kuroki Y., Toyoda A.,
RA Suzuki Y., Hashimoto S.-I., Yamaguchi K., Sugano S., Kohara Y.,
RA Fujiyama A., Anterola A., Aoki S., Ashton N., Barbazuk W.B., Barker E.,
RA Bennetzen J.L., Blankenship R., Cho S.H., Dutcher S.K., Estelle M.,
RA Fawcett J.A., Gundlach H., Hanada K., Heyl A., Hicks K.A., Hughes J.,
RA Lohr M., Mayer K., Melkozernov A., Murata T., Nelson D.R., Pils B.,
RA Prigge M., Reiss B., Renner T., Rombauts S., Rushton P.J., Sanderfoot A.,
RA Schween G., Shiu S.-H., Stueber K., Theodoulou F.L., Tu H., Van de Peer Y.,
RA Verrier P.J., Waters E., Wood A., Yang L., Cove D., Cuming A.C., Hasebe M.,
RA Lucas S., Mishler B.D., Reski R., Grigoriev I.V., Quatrano R.S.,
RA Boore J.L.;
RT "The Physcomitrella genome reveals evolutionary insights into the conquest
RT of land by plants.";
RL Science 319:64-69(2008).
CC -!- FUNCTION: Regulator of biological processes that recruits a histone
CC deacetylase to control gene transcription. May play a role in the entry
CC into mitosis, negatively regulating the cell proliferation. Formation
CC of stable complexes with geminiviridae replication-associated proteins
CC may create a cellular environment which favors viral DNA replication
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000305}.
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DR EMBL; DS545013; EDQ64821.1; -; Genomic_DNA.
DR RefSeq; XP_001770331.1; XM_001770279.1.
DR AlphaFoldDB; A9SVH7; -.
DR PRIDE; A9SVH7; -.
DR InParanoid; A9SVH7; -.
DR Proteomes; UP000006727; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; PTHR13742; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 3: Inferred from homology;
KW Cell cycle; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1116
FT /note="Retinoblastoma-related protein"
FT /id="PRO_0000380238"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 42..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..980
FT /note="Pocket"
FT /evidence="ECO:0000250"
FT REGION 540..735
FT /note="Domain A"
FT /evidence="ECO:0000250"
FT REGION 736..859
FT /note="Spacer"
FT /evidence="ECO:0000250"
FT REGION 791..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..980
FT /note="Domain B"
FT /evidence="ECO:0000250"
FT COMPBIAS 1..17
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 124030 MW; F7258CF272C831BD CRC64;
MERAGPVLRE VKVRSHRQSS LMSESVKQAD IEDSQVFCKQ EPVEDNIESG YETPTKSSRA
GLGDKTPNGG DIKPRKKAWS PVYLEGLEGR FREHCEVGLC LDDPTLQQAL RLFKESKPLL
LANIDSIGTS TVEDTERLWG GCVLYVVKAL SCGATVDGDK SESNAVGFTL SQLMRQTKIR
HARELDMISI CAITECLLEL PHFLVKVGPI VKQMYGDEWE KRLQVKEVQA NFVHLTALFT
YFKRVYQDFF LSPDTFTNIV SRSLSGVRDE HHVSVHMQFG WMLFLALRMH VIQQFSDLVT
CTNALMAVMF CEPLSGAWSK SNLGFCFFVF MQVILILHMP PDLRKFSLQD PVRFAKRSSE
GVDLVASLCA TYYAADEDVS SLLEKANATI SKLFGKPMKG GLAYLEGLMD KKSLAANLRM
LEKDYEDSYQ SRGGLDERMF INGEDGLLGT LSNESPRFSG SKVLFLVPSL HVDECKVKSS
FPLTNVPVYQ RKFDIMASPV RFGAFSMGAA PSSPAASPWS SPVKHMGTQG SSGGKRPPST
PVTITMTTAK WLRTVITPLA AEPSVELQLF FRSCDRDISA DVKNRAHVLL DLIFSAERGG
GWQGVAGLMD VWPEQRKLEA IKLYYKVLGA MCRSEEQRLH THNLTSLLSN ERFHRCMIAC
SAELVLATHK TVTMGFPAVL EPAGITAFDL SKVIEYFVRH EETLPRELKR HLNTIEERIL
ESMAWEKGSS MYNSLIVARP SLANEINRLC LLADPMPALE NLATQVRPAT VMHRIPGLSK
SGHSGEVACA AHTPTSASSP PQNGSSTSEA GFLSPVKDRP SAFSAFSSPM RNRLRAPLQS
AFASPQRPSP LGGGETCADT VINVFFQKAL VLAAVRIRTV CERIGQPQHL IERVYKVFQH
ALHHETSLFF NRHIDQLVLC TIYGVCKKPS YSVSGFRSYR HSCDMAMRMT LWINFQKTGG
LESGDIIKFY NDVFVHVTKK FLVQVDTNSS MRSPRKAHGS DGNDGTISKL LKDEMEVIII
KGEAPGSPVA SIFSTFPDIS PKKVSALHNV FVSPLRSSKV DKLMSPRTRT LYACVGESTR
DYQSPSKDLT AINNRLNKRF IAHGDLAGWT LKTDPQ
