ID   RBR_PILOF               Reviewed;        1008 AA.
AC   B1ABS0;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Retinoblastoma-related protein;
GN   Name=RBR;
OS   Pilosella officinarum (Mouse-ear hawkweed) (Hieracium pilosella).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae;
OC   Hieraciinae; Pilosella.
OX   NCBI_TaxID=221204;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. P4;
RX   PubMed=18812497; DOI=10.1105/tpc.108.059287;
RA   Rodrigues J.C.M., Tucker M.R., Johnson S.D., Hrmova M., Koltunow A.M.G.;
RT   "Sexual and apomictic seed formation in Hieracium requires the plant
RT   polycomb-group gene FERTILIZATION INDEPENDENT ENDOSPERM.";
RL   Plant Cell 20:2372-2386(2008).
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; EU439053; ABZ85632.1; -; mRNA.
DR   AlphaFoldDB; B1ABS0; -.
DR   SMR; B1ABS0; -.
DR   IntAct; B1ABS0; 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1008
FT                   /note="Retinoblastoma-related protein"
FT                   /id="PRO_0000380234"
FT   REGION          375..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          404..853
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          404..605
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          606..722
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          723..853
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
FT   REGION          865..899
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          988..1008
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1008 AA;  112938 MW;  AF5B5C6F174E66C1 CRC64;
     MEDLQPINPN TDSPTETGAT TIEARFSDFC KGRLTMDDNA LEEAMKLFNQ SKHLFMTNAS
     ALGSGTPEEA EHYWFAFILF SMKRLSKKND GEDAAKSSEN SFKLYQILRV AKLNFVDFFK
     ELPQFIVKTG PILSNLYGSD WETRLQAKEL QANFVHLSLL SKFYKRAFKT LFKATHENVE
     GQSAVANSAD YISNCHRFGW MLFLALRVHA FSRFKDLVTC TNGLVSILAI LIIHIPARFR
     NFSMSDSSRF VKKDDKVVDL LASLCNMYET SEDELRKTVV RTNIVVEEIL KKDPSMASEC
     TNGNLDNIDT DDLTYFQDLL EEQSLSSDLD VLEKDYDDAM LLEGELDERL FINDEESLLG
     SSSLSGGAIN MTGTKRKVDS MTSPTKTITS PLSPYKSPSK MISTPVSTAM TTAKWLRTVV
     SPLSSFPSVD LTRFLQSCDK DVTSDVIKRA RIILEAIFPS SGIPDRTIIS NTQTTNLMDN
     IWAEQRRLEA LKLYYRVLHA MCKAESQILH GNNLTSLLTN ERFHRCMLAC SAELVLATHK
     TVTMLFPAVL ERTGITAFDL SKVIESFIRH EEPLPRELRR HLNSLEERLL ESMVWEKGSS
     MYNSLTIARP NLSNEINRLG LLADPMPSLD AIALQCNMSC GGLPPVPKRD TSPGKSGEIR
     SPKRVCNEYR SVLVERNSFT SPVKDRLLGI NNLKSKILSP ALQSAFASPT RPHPTRGETC
     GETAVNLFFS KIVKLAAVRI NGMVERMQLT QQIRERVYCL FQQILGQRTS LFFNRHIDQI
     ILCCFYGVAK ISQLSLTFKE IIFNYRKQPH CKPQVFRAVF VDDRSSSRRS KTGQDHVDII
     MFYNEVFIPS VKPLLVELAP SNVPKNPNNQ VSDSNKKDES GPCPCPGSPK VSSFPSLPDM
     SPKKVSAVHN VYVSPLRSTK MDALISHGSK SYYACVGEST HAYQSPSKDL TAINNRLNGT
     RKVRGSLNFD EVDVGLVSDS LVTQSLYLQN GQNGKGPSSS SGQELKTE