RBR_POPTR
ID RBR_POPTR Reviewed; 1035 AA.
AC B9GLX8;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Retinoblastoma-related protein;
GN Name=RBL901; ORFNames=POPTRDRAFT_547794;
OS Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp.
OS trichocarpa).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus.
OX NCBI_TaxID=3694;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nisqually;
RX PubMed=16973872; DOI=10.1126/science.1128691;
RA Tuskan G.A., Difazio S., Jansson S., Bohlmann J., Grigoriev I.,
RA Hellsten U., Putnam N., Ralph S., Rombauts S., Salamov A., Schein J.,
RA Sterck L., Aerts A., Bhalerao R.R., Bhalerao R.P., Blaudez D., Boerjan W.,
RA Brun A., Brunner A., Busov V., Campbell M., Carlson J., Chalot M.,
RA Chapman J., Chen G.-L., Cooper D., Coutinho P.M., Couturier J., Covert S.,
RA Cronk Q., Cunningham R., Davis J., Degroeve S., Dejardin A.,
RA dePamphilis C.W., Detter J., Dirks B., Dubchak I., Duplessis S.,
RA Ehlting J., Ellis B., Gendler K., Goodstein D., Gribskov M., Grimwood J.,
RA Groover A., Gunter L., Hamberger B., Heinze B., Helariutta Y.,
RA Henrissat B., Holligan D., Holt R., Huang W., Islam-Faridi N., Jones S.,
RA Jones-Rhoades M., Jorgensen R., Joshi C., Kangasjaervi J., Karlsson J.,
RA Kelleher C., Kirkpatrick R., Kirst M., Kohler A., Kalluri U., Larimer F.,
RA Leebens-Mack J., Leple J.-C., Locascio P., Lou Y., Lucas S., Martin F.,
RA Montanini B., Napoli C., Nelson D.R., Nelson C., Nieminen K., Nilsson O.,
RA Pereda V., Peter G., Philippe R., Pilate G., Poliakov A., Razumovskaya J.,
RA Richardson P., Rinaldi C., Ritland K., Rouze P., Ryaboy D., Schmutz J.,
RA Schrader J., Segerman B., Shin H., Siddiqui A., Sterky F., Terry A.,
RA Tsai C.-J., Uberbacher E., Unneberg P., Vahala J., Wall K., Wessler S.,
RA Yang G., Yin T., Douglas C., Marra M., Sandberg G., Van de Peer Y.,
RA Rokhsar D.S.;
RT "The genome of black cottonwood, Populus trichocarpa (Torr. & Gray).";
RL Science 313:1596-1604(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nisqually;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Grigoriev I.V., Terry A., Salamov A.A., Otillar R., Lou Y., Lucas S.,
RA Hammon N., Glavina del Rio T., Detter J., Kalin E., Tice H., Pitluck S.,
RA Chapman J., Putnam N.H., Brunner A., Busov V., Campbell M., Chalot M.,
RA Covert S., Davis J., DiFazio S., Gribskov M., Gunter L., Hamberger B.,
RA Jansson S., Joshi C., Larimer F., Martin F., Napoli C., Nelson D.,
RA Ralph S., Rombauts S., Rouze P., Schrader J., Tsai C., Vahala J.,
RA Tuskan G., Rokhsar D.;
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulator of biological processes that recruits a histone
CC deacetylase to control gene transcription. May play a role in the entry
CC into mitosis, negatively regulating the cell proliferation. Formation
CC of stable complexes with geminiviridae replication-associated proteins
CC may create a cellular environment which favors viral DNA replication
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000305}.
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DR EMBL; CM009290; EEE82535.1; -; Genomic_DNA.
DR RefSeq; XP_002297730.1; XM_002297694.1.
DR AlphaFoldDB; B9GLX8; -.
DR SMR; B9GLX8; -.
DR STRING; 3694.POPTR_0001s06870.1; -.
DR EnsemblPlants; PNT52428; PNT52428; POPTR_001G031400v3.
DR EnsemblPlants; PNT52429; PNT52429; POPTR_001G031400v3.
DR GeneID; 7455806; -.
DR Gramene; PNT52428; PNT52428; POPTR_001G031400v3.
DR Gramene; PNT52429; PNT52429; POPTR_001G031400v3.
DR KEGG; pop:7455806; -.
DR eggNOG; KOG1010; Eukaryota.
DR HOGENOM; CLU_015949_0_0_1; -.
DR InParanoid; B9GLX8; -.
DR OMA; AILCELH; -.
DR Proteomes; UP000006729; Chromosome 1.
DR ExpressionAtlas; B9GLX8; baseline and differential.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; PTHR13742; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 3: Inferred from homology;
KW Cell cycle; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..1035
FT /note="Retinoblastoma-related protein"
FT /id="PRO_0000380239"
FT REGION 403..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..885
FT /note="Pocket"
FT /evidence="ECO:0000250"
FT REGION 431..632
FT /note="Domain A"
FT /evidence="ECO:0000250"
FT REGION 633..753
FT /note="Spacer"
FT /evidence="ECO:0000250"
FT REGION 674..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..885
FT /note="Domain B"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1035 AA; 114642 MW; 7A79E6F60156F2F3 CRC64;
MSPAALKNME ENKTTVMTTS HSSNDGGETV KGYSDAVEVR FSDFCKSGLA LDENTCTQAI
KLFKDTKHLL MTNVSSIGNG TSEEAERFWF AFVSYSVKRL SEKNRDDAQQ KSDDPGLTLC
QILRLAKLNI VDFFKELPHF IVKAGPILSN IYGADWENRL EAKELQANFV HLSILSRHYK
RACRELFLTS DASSDKQPAI SNEATHVSDH HRFGWLLFLA LRVHAFSRFK DLVTCTNGLV
SVLAVLIIHV PVRFRNFSFN DSQWFVRKGD KGVDLLASLC NKYDTSEEVL RKSMETTNNL
IANILKKKPH SASEYKNENL VNINPDGLIY YEDLMEESSL QSSLNILEKD YDDAIRNKAE
LDERVFINEE DSLLGSGSVS AGSLNITGAK RKFDLISSPT KTITSPLSPH RSPASHANGI
PGSANSKMAA TPVSTAMTTA KWLRTIISPL PSKPSAQLER FLVSCDKDVT NDVIRRAQII
LEAIFPSSSL GERCVNGSLQ STNLMDNIWA EQRRLEALKL YYRVLESMCT AEAQILHATN
LTSLLTNERF HRCMLACSAE LVVATYKTVT MLFPAVLERT GITAFDLSKV IESFIRHEES
LPRELRRHLN SLEERLLDSM VWEKGSSLYN SLTVARPALS AEINRLGLLA EPMPSLDAIA
MHINFSSGCL PPVPSLQKHE TSPGSGQNGD LRSPKRPCTD FRSVLVERNS FTSPVKDRLL
GNLKSKLPPP PLQSAFASPT RPNPGGGGET CAETGINVFF TKINKLAAVR INGMIEKLQP
SQQHIRENVY RLFQLILSHQ TSLFFNRHID QIILCCFYGV AKISKLNLTF REIIYNYRRQ
PHCKTLVFRS VFVDWSSARH NGRTGQDHVD IITFYNEIFI PAAKPLLVDV GSAGTTVKAS
NVPEVGNNKD GQCPASPKVS PFPSLPDMSP KKVSSAHNVY VSPLRSSKMD ALISNSSKSY
YACVGESTHA YQSPSKDLNA INNRLNGNRK ARGTLNLDND VGLVSDSMVA NSLGLQNGNC
ASTSGAALKS EQSDS