ID   RBR_RICCO               Reviewed;        1020 AA.
AC   B9SVG9;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Retinoblastoma-related protein;
GN   Name=RBR; ORFNames=RCOM_1264670;
OS   Ricinus communis (Castor bean).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Acalyphoideae; Acalypheae;
OC   Ricinus.
OX   NCBI_TaxID=3988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Hale;
RX   PubMed=20729833; DOI=10.1038/nbt.1674;
RA   Chan A.P., Crabtree J., Zhao Q., Lorenzi H., Orvis J., Puiu D.,
RA   Melake-Berhan A., Jones K.M., Redman J., Chen G., Cahoon E.B., Gedil M.,
RA   Stanke M., Haas B.J., Wortman J.R., Fraser-Liggett C.M., Ravel J.,
RA   Rabinowicz P.D.;
RT   "Draft genome sequence of the oilseed species Ricinus communis.";
RL   Nat. Biotechnol. 28:951-956(2010).
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; EQ974168; EEF32393.1; -; Genomic_DNA.
DR   RefSeq; XP_002529988.1; XM_002529942.2.
DR   AlphaFoldDB; B9SVG9; -.
DR   SMR; B9SVG9; -.
DR   STRING; 3988.XP_002529988.1; -.
DR   PRIDE; B9SVG9; -.
DR   GeneID; 8283405; -.
DR   KEGG; rcu:8283405; -.
DR   eggNOG; KOG1010; Eukaryota.
DR   InParanoid; B9SVG9; -.
DR   OrthoDB; 113612at2759; -.
DR   Proteomes; UP000008311; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1020
FT                   /note="Retinoblastoma-related protein"
FT                   /id="PRO_0000380240"
FT   REGION          382..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..869
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          415..616
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          617..737
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          738..869
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1020 AA;  114026 MW;  F02C2121441F73BF CRC64;
     MEDMKPSTAS TKNLHHDGVG ENDTIEVRFT DFCKIGLSVS EDAYEEAIKL FKGTKHLLLA
     NISAIGNGMP EEAERFWFAF VSYSVKRLSE KIRDNMQQRP DDNGLTLCQI LRRAKLNIVD
     FFKELPQYVV KAGPILSTMY GVDWENRLEA KELQANFVHL SILSRHYKRA YRELFLTSDA
     NVDKQSATAY MSDYHRFGWL LFLALRVHAF SRFKDLVTCT NGLVSVLAIL IIHVPVRFRN
     FNLNDSQRFV KKGDKGVDLL ASLCNKYDTS EDELRKTMEK TNNLIADILK KKPHMASEYK
     NENLDNINTD GLIYYEDLME ESSLRSSLDI LEKDYEDAIR CKGELDERVF INEEDSLLGS
     GSLSGGAISV TGTKRKFDQI SSPTKTITSP LSPHRSPASH TNGILGSTNS RMAATPVSTA
     MTTAKWLRTV ISPLPSKPSP QLERFLASCD RDVTNDVIRR AHIILEAIFP SNALGERCVT
     GSLQSTNLMD NIWAEQRRLE ALKLYYRVLE AMCTAEAQIL HATNLTSLLT NERFHRCMLA
     CSAELVLATH KTVTMLFPAV LERTGITAFD LSKVIESFIR HEESLPRELR RHLNSLEERL
     LESMVWEKGS SMYNSLTVAR PSLSAEINRL GLLAEPMPSL DAIAVHINFS SGGLPPLSSV
     SKHEISPGQN GDIRSPKRPC TDYRSVLVER NSFTSPVKDR LLAFTNLKSK LPPPPLQSAF
     ASPTRPNPGG GGETCAETGI NIFFSKINKL AAVRINGMVE RLQQSQQHIR ENVYRLFQQV
     LSQQTSLFFN RHIDQIILCC FYGVAKISKV NLTFREIIYN YRKQPQCKPQ VFRSVFVDWS
     SARHNGRTGQ DHVDIITFYN EIFIPAAKPL LVEVGSAGIT VKGSQVPEVN NNKDGQCPAS
     PKVSPFPSLP DMSPKKVSAA HNVYVSPLRT SKMDALISHS SKSYYACVGE STHAYQSPSK
     DLTAINNRLN GNRNIRGSLN FDDVDVGLVS DSMVAKSLYL QNGSCASTSG APLKTEQPDP