ID   RBR_SCUBA               Reviewed;        1006 AA.
AC   Q4JF75;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Retinoblastoma-related protein;
GN   Name=RB;
OS   Scutellaria baicalensis (Baical skullcap).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Lamiaceae; Scutellarioideae; Scutellaria.
OX   NCBI_TaxID=65409;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Shoyama Y., Morimoto S., Taura F.;
RT   "The genes involved in hypersensitive responses and cell proliferation in
RT   Scutellaria baicalensis.";
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of biological processes that recruits a histone
CC       deacetylase to control gene transcription. May play a role in the entry
CC       into mitosis, negatively regulating the cell proliferation. Formation
CC       of stable complexes with geminiviridae replication-associated proteins
CC       may create a cellular environment which favors viral DNA replication
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC       {ECO:0000305}.
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DR   EMBL; AB205136; BAE06273.1; -; mRNA.
DR   AlphaFoldDB; Q4JF75; -.
DR   SMR; Q4JF75; -.
DR   PRIDE; Q4JF75; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR002720; RB_A.
DR   InterPro; IPR002719; RB_B.
DR   InterPro; IPR028309; RB_fam.
DR   InterPro; IPR024599; RB_N.
DR   PANTHER; PTHR13742; PTHR13742; 1.
DR   Pfam; PF11934; DUF3452; 1.
DR   Pfam; PF01858; RB_A; 1.
DR   Pfam; PF01857; RB_B; 1.
DR   SMART; SM01367; DUF3452; 1.
DR   SMART; SM01368; RB_A; 1.
DR   SUPFAM; SSF47954; SSF47954; 2.
PE   2: Evidence at transcript level;
KW   Cell cycle; Nucleus; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1006
FT                   /note="Retinoblastoma-related protein"
FT                   /id="PRO_0000380241"
FT   REGION          411..855
FT                   /note="Pocket"
FT                   /evidence="ECO:0000250"
FT   REGION          411..604
FT                   /note="Domain A"
FT                   /evidence="ECO:0000250"
FT   REGION          605..724
FT                   /note="Spacer"
FT                   /evidence="ECO:0000250"
FT   REGION          725..855
FT                   /note="Domain B"
FT                   /evidence="ECO:0000250"
FT   REGION          866..898
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        866..897
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1006 AA;  111795 MW;  D400F3EABBACB48E CRC64;
     MTELKKIPSP SHPADEGGNT IEARFAHFSK NDLRLDDDKF LAQATKLLDE SKHLLMANVP
     ALGTGTLDEA ERYWFAFVLY SVRKLSENGD SVEKGLNLCQ ILRAARLNID DFYKELYQFL
     IKVGSILSNL YGGDWQKRLE AKESHTNFVH LFCLSKKYKN AYRELFSIVN ANNDKQLNVA
     NASGCESDYY RFGWLLFLAL RVHVFRPCKT LVSCTHGLVS VLAILLIHVP AHFRNLNLND
     SERIVMRGDK ADLVASLCNM YGTSEDELRK TLEKANNLIT DILKKKPCLA SECKPANLEN
     IVTDGLVYFE GLMDESSLSS SIYLLEKDYD AATHDMDGLD EMIFLNENDS LLGSGSLSGG
     ATNSYGNGTK RKLDAMSSPA KTITSPLSPH RSPICHSNGF IVGGISKMAS TPVTTAMTTA
     KWLRTVIAPL PSKPSAELEK FLTSCDRDVT PDVTRRAQII LEAIFPSSGL GQNASLMDNI
     WAEQRRMEAM KLYFRVLQAL CTAESQILHA NNLTSLLTNE RFHRCMLACS AELVLATHKT
     VTMLFPTVLE RTGITAFDLS KVIESFIRHE ESLPRELRRH LNSLEERLLE SMVWEKGSSM
     YNSLIVARPA LSAEISRLGL LAEPMPSLDA IAMHNNMSCG VLPPMQALLK HEKHGQNGDI
     RSPKRVCTEY RSVLVERNSF TSPVKDRLLA LNNLKSKFPP PILHSAFASP TRPSPGGGGE
     TCAETAVNVF FSKIVKLAAV RINGMVERLQ LSQQIRESVY CLFQKILSQR TTLFFNRHID
     QILLCCFYGV SKISQLTLTF KEIIFNYRKQ PQCKPQVFRN VYVDWKALRR TGKSGPDHVD
     IITFYNEIFV PAVKPLLVEI APGGSAQSGS QVPEAKNNTN GVNPSSPRTS SFPSLPDMSP
     KKVSAAHNVY VSPLRSSKMD ALISHSSRSY YACVGESTHA YQSPSKDLTA INNRLNGNRK
     VRGTLNFDDV DVGLVTDSVV ANSLYVQNGS CASSSHMVVK SEQQDS