RBR_VITVI
ID RBR_VITVI Reviewed; 1007 AA.
AC A7P514;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Retinoblastoma-related protein;
GN Name=RBR; ORFNames=GSVIVT00032361001, LOC100261011;
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Pinot noir / PN40024;
RX PubMed=17721507; DOI=10.1038/nature06148;
RA Jaillon O., Aury J.-M., Noel B., Policriti A., Clepet C., Casagrande A.,
RA Choisne N., Aubourg S., Vitulo N., Jubin C., Vezzi A., Legeai F.,
RA Hugueney P., Dasilva C., Horner D., Mica E., Jublot D., Poulain J.,
RA Bruyere C., Billault A., Segurens B., Gouyvenoux M., Ugarte E.,
RA Cattonaro F., Anthouard V., Vico V., Del Fabbro C., Alaux M.,
RA Di Gaspero G., Dumas V., Felice N., Paillard S., Juman I., Moroldo M.,
RA Scalabrin S., Canaguier A., Le Clainche I., Malacrida G., Durand E.,
RA Pesole G., Laucou V., Chatelet P., Merdinoglu D., Delledonne M.,
RA Pezzotti M., Lecharny A., Scarpelli C., Artiguenave F., Pe M.E., Valle G.,
RA Morgante M., Caboche M., Adam-Blondon A.-F., Weissenbach J., Quetier F.,
RA Wincker P.;
RT "The grapevine genome sequence suggests ancestral hexaploidization in major
RT angiosperm phyla.";
RL Nature 449:463-467(2007).
CC -!- FUNCTION: Regulator of biological processes that recruits a histone
CC deacetylase to control gene transcription. May play a role in the entry
CC into mitosis, negatively regulating the cell proliferation. Formation
CC of stable complexes with geminiviridae replication-associated proteins
CC may create a cellular environment which favors viral DNA replication
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A7P514; -.
DR SMR; A7P514; -.
DR STRING; 29760.VIT_04s0008g02780.t01; -.
DR PRIDE; A7P514; -.
DR eggNOG; KOG1010; Eukaryota.
DR ExpressionAtlas; A7P514; baseline and differential.
DR GO; GO:0070176; C:DRM complex; IEA:EnsemblPlants.
DR GO; GO:0003677; F:DNA binding; IEA:EnsemblPlants.
DR GO; GO:0008356; P:asymmetric cell division; IEA:EnsemblPlants.
DR GO; GO:0001708; P:cell fate specification; IEA:EnsemblPlants.
DR GO; GO:0009567; P:double fertilization forming a zygote and endosperm; IEA:EnsemblPlants.
DR GO; GO:0009553; P:embryo sac development; IEA:EnsemblPlants.
DR GO; GO:0009960; P:endosperm development; IEA:EnsemblPlants.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:EnsemblPlants.
DR GO; GO:0022619; P:generative cell differentiation; IEA:EnsemblPlants.
DR GO; GO:0010377; P:guard cell fate commitment; IEA:EnsemblPlants.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:EnsemblPlants.
DR GO; GO:0048366; P:leaf development; IEA:EnsemblPlants.
DR GO; GO:1903866; P:palisade mesophyll development; IEA:EnsemblPlants.
DR GO; GO:0001558; P:regulation of cell growth; IEA:EnsemblPlants.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IEA:EnsemblPlants.
DR GO; GO:0006349; P:regulation of gene expression by genomic imprinting; IEA:EnsemblPlants.
DR GO; GO:2000653; P:regulation of genetic imprinting; IEA:EnsemblPlants.
DR GO; GO:0051783; P:regulation of nuclear division; IEA:EnsemblPlants.
DR GO; GO:2000036; P:regulation of stem cell population maintenance; IEA:EnsemblPlants.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0010090; P:trichome morphogenesis; IEA:EnsemblPlants.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; PTHR13742; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 2: Evidence at transcript level;
KW Cell cycle; Nucleus; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..1007
FT /note="Retinoblastoma-related protein"
FT /id="PRO_0000380243"
FT REGION 406..856
FT /note="Pocket"
FT /evidence="ECO:0000250"
FT REGION 406..604
FT /note="Domain A"
FT /evidence="ECO:0000250"
FT REGION 605..725
FT /note="Spacer"
FT /evidence="ECO:0000250"
FT REGION 644..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..856
FT /note="Domain B"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1007 AA; 111715 MW; D41F82CC5A2E216C CRC64;
MDGVKPVASA EQGGAVEARF TEFCKNGLQL DESTFAQAMK LFEESNHLLS TTSLSAIGNG
VPEDSERYWF AFILYSVKRL SEGTAENVQQ GNDENGFNLC QILRVSKLNI VDFFKELPQF
IVKVGPILGN LYGPDWEKRL EAKELQANFV HLSILSKYYK RAYLEFFSTS GSNLDKQSSV
ISASGYVSDY HRFGWLLFLA LRVHAFSRFK DLVTCTNGLV SILAILILHV PISFRSFTIN
NYPRFVKKGN KGMDLLASLC DIYETSEDEV RKTMEQTNKV IVDILKKKPC LASECKSENL
ASIDPDGLVY FEDLMDESSL SSSINILEKD YDAAIRNKGE LDERVFINGE DSLLGSGSLS
GGAMSISGAK RKIDSLASPA KTITSPLSPN RSPGILGGAN SKMAPTPVTT AMTTAKWLRT
VISPLPSKPS AELERFLTSC DKDVTSDVIR RANVILEAIF PSIAFGERCV TGSASLMDSI
WAQQRRMEAM KLYYRVLEAM CTAEAQVLHA NNLTSLLTNE RFHRCMLACS AELVLATHKT
VTMLFPAVLE RTGITAFDLS KVIESFIRHE ESLPRELRRH LNSLEERLLE SMVWEKGSSM
YNSLIVARAA LSAEVNRLGL LAEPMPSLDA ISMHINASCG GLPPVPSLQK RESSPGQNGD
IRSPKRVCPD YRSVLVERNS FTSPVKDRFL ALNNLKSKLP PPPLQSAFAS PTRPNPGREG
ETCAETGINI FFSKIIKLAA VRINGMVERL QLSQQMRENV YCLFQQILNR RTSLFFNRHI
DQIILCCFYG LAKISQMNLT FREIIHNYRK QPQCKPQIFR SVFVDWSSAR RNGKTGKEHV
DIITFYNEIF IPAVKPLLME IGPGGGTTTK TNRVPEVNNN NDAQCPESPK ISPFPSLPDM
SPKKVSAAHN VYVSPLRSSK MDALISHSSK SYYACVGEST HAYQSPSKDL TAINNRLNST
RKLRGALNFD DVEGLVSDSL VAKSLYLQNG SCASSSGAPL KLEQPDT
