RBSA2_ECO57
ID RBSA2_ECO57 Reviewed; 506 AA.
AC Q8X5Q4; Q7A905;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 3.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Ribose import ATP-binding protein RbsA 2 {ECO:0000255|HAMAP-Rule:MF_01716};
DE EC=7.5.2.7 {ECO:0000255|HAMAP-Rule:MF_01716};
GN Name=rbsA2 {ECO:0000255|HAMAP-Rule:MF_01716};
GN OrderedLocusNames=Z5691, ECs5073;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Part of the ABC transporter complex RbsABC involved in ribose
CC import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01716}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) +
CC phosphate; Xref=Rhea:RHEA:29903, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:47013, ChEBI:CHEBI:456216; EC=7.5.2.7;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01716};
CC -!- SUBUNIT: The complex is composed of an ATP-binding protein (RbsA), two
CC transmembrane proteins (RbsC) and a solute-binding protein (RbsB).
CC {ECO:0000255|HAMAP-Rule:MF_01716}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01716}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01716}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Ribose importer
CC (TC 3.A.1.2.1) family. {ECO:0000255|HAMAP-Rule:MF_01716}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG59288.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE005174; AAG59288.1; ALT_INIT; Genomic_DNA.
DR EMBL; BA000007; BAB38496.1; -; Genomic_DNA.
DR PIR; A91263; A91263.
DR PIR; D86103; D86103.
DR RefSeq; NP_313100.1; NC_002695.1.
DR RefSeq; WP_001089388.1; NZ_SEKU01000001.1.
DR AlphaFoldDB; Q8X5Q4; -.
DR SMR; Q8X5Q4; -.
DR STRING; 155864.EDL933_5434; -.
DR EnsemblBacteria; AAG59288; AAG59288; Z5691.
DR EnsemblBacteria; BAB38496; BAB38496; ECs_5073.
DR GeneID; 914265; -.
DR KEGG; ece:Z5691; -.
DR KEGG; ecs:ECs_5073; -.
DR PATRIC; fig|386585.9.peg.5301; -.
DR eggNOG; COG1129; Bacteria.
DR HOGENOM; CLU_000604_92_3_6; -.
DR OMA; RIDHKAT; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015611; F:ABC-type D-ribose transporter activity; IEA:RHEA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR PROSITE; PS51254; RBSA; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Membrane;
KW Nucleotide-binding; Reference proteome; Repeat; Sugar transport;
KW Translocase; Transport.
FT CHAIN 1..506
FT /note="Ribose import ATP-binding protein RbsA 2"
FT /id="PRO_0000261065"
FT DOMAIN 7..242
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01716"
FT DOMAIN 250..497
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01716"
FT BINDING 39..46
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01716"
SQ SEQUENCE 506 AA; 55188 MW; 31CB364ECAD0C9CA CRC64;
MNSTPVLEMR NIAKAFGKFY ALKGVDLTVY PGEIHALMGE NGAGKSTLMK VLAGAYTATS
GEILIDGKPF HIRTPKDALS AGITLIYQEM QLAPNLSVAE NIFLGSELSH GGLVQRKEML
VQAQKVIDRL GAQFNASDKV MTLTIAEQQQ VEIARALHRN SRILVMDEPT AALSSRETHR
LFELIMRLRD EGMAIIYISH RMAEVYELSD RVSVLRDGQY VGSLTRDNLN AGELVRMMVG
RPLSDLFNKE RDIPLGKARL NVHHLTDGGK VQPSSLLVRS GEIVGLAGLV GAGRSELAQL
IFGVRKATGG MIEVDGEPVV IHSPREAIDL GIGFLTENRK EQGLFLEMAA AENITMATLE
RDARWGMLNR KKAQTISDDA IKLLNIRVPH AQVRAGGLSG GNQQKLLISR WVAIGPRILL
LDEPARGVDV GAKSEIYRIM NEMARKGVAI LMISSELPEI VGMSDRVYVM REGSIAGELN
GKNITQENIM TLATGVNDAH SQAVTS
