RBSD_STAA8
ID RBSD_STAA8 Reviewed; 134 AA.
AC Q2G1A5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=D-ribose pyranase {ECO:0000255|HAMAP-Rule:MF_01661};
DE EC=5.4.99.62 {ECO:0000255|HAMAP-Rule:MF_01661};
GN Name=rbsD {ECO:0000255|HAMAP-Rule:MF_01661};
GN OrderedLocusNames=SAOUHSC_00240;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: Catalyzes the interconversion of beta-pyran and beta-furan
CC forms of D-ribose. {ECO:0000255|HAMAP-Rule:MF_01661}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-ribopyranose = beta-D-ribofuranose;
CC Xref=Rhea:RHEA:25432, ChEBI:CHEBI:27476, ChEBI:CHEBI:47002;
CC EC=5.4.99.62; Evidence={ECO:0000255|HAMAP-Rule:MF_01661};
CC -!- PATHWAY: Carbohydrate metabolism; D-ribose degradation; D-ribose 5-
CC phosphate from beta-D-ribopyranose: step 1/2. {ECO:0000255|HAMAP-
CC Rule:MF_01661}.
CC -!- SUBUNIT: Homodecamer. {ECO:0000255|HAMAP-Rule:MF_01661}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01661}.
CC -!- SIMILARITY: Belongs to the RbsD / FucU family. RbsD subfamily.
CC {ECO:0000255|HAMAP-Rule:MF_01661}.
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DR EMBL; CP000253; ABD29415.1; -; Genomic_DNA.
DR RefSeq; WP_000747873.1; NZ_LS483365.1.
DR RefSeq; YP_498835.1; NC_007795.1.
DR PDB; 3P12; X-ray; 2.35 A; A/B/C/D=1-134.
DR PDB; 3P13; X-ray; 2.35 A; A/B/C/D=1-134.
DR PDBsum; 3P12; -.
DR PDBsum; 3P13; -.
DR AlphaFoldDB; Q2G1A5; -.
DR SMR; Q2G1A5; -.
DR STRING; 1280.SAXN108_0250; -.
DR EnsemblBacteria; ABD29415; ABD29415; SAOUHSC_00240.
DR GeneID; 3919260; -.
DR KEGG; sao:SAOUHSC_00240; -.
DR PATRIC; fig|93061.5.peg.220; -.
DR eggNOG; COG1869; Bacteria.
DR HOGENOM; CLU_135498_0_0_9; -.
DR OMA; IIRTGEC; -.
DR UniPathway; UPA00916; UER00888.
DR EvolutionaryTrace; Q2G1A5; -.
DR PRO; PR:Q2G1A5; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0062193; F:D-ribose pyranase activity; IEA:UniProtKB-EC.
DR GO; GO:0016872; F:intramolecular lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016866; F:intramolecular transferase activity; IBA:GO_Central.
DR GO; GO:0048029; F:monosaccharide binding; IEA:InterPro.
DR GO; GO:0019303; P:D-ribose catabolic process; IBA:GO_Central.
DR Gene3D; 3.40.1650.10; -; 1.
DR HAMAP; MF_01661; D_rib_pyranase; 1.
DR InterPro; IPR023064; D-ribose_pyranase.
DR InterPro; IPR023750; RbsD-like_sf.
DR InterPro; IPR007721; RbsD_FucU.
DR PANTHER; PTHR37831; PTHR37831; 1.
DR Pfam; PF05025; RbsD_FucU; 1.
DR SUPFAM; SSF102546; SSF102546; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Carbohydrate metabolism; Cytoplasm; Isomerase;
KW Reference proteome.
FT CHAIN 1..134
FT /note="D-ribose pyranase"
FT /id="PRO_0000346271"
FT ACT_SITE 20
FT /note="Proton donor"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01661"
FT BINDING 28
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01661"
FT BINDING 99
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01661"
FT BINDING 123..125
FT /ligand="substrate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01661"
FT HELIX 9..16
FT /evidence="ECO:0007829|PDB:3P12"
FT STRAND 23..27
FT /evidence="ECO:0007829|PDB:3P12"
FT STRAND 39..41
FT /evidence="ECO:0007829|PDB:3P12"
FT HELIX 51..59
FT /evidence="ECO:0007829|PDB:3P12"
FT STRAND 64..70
FT /evidence="ECO:0007829|PDB:3P12"
FT HELIX 73..76
FT /evidence="ECO:0007829|PDB:3P12"
FT HELIX 78..87
FT /evidence="ECO:0007829|PDB:3P12"
FT STRAND 92..97
FT /evidence="ECO:0007829|PDB:3P12"
FT HELIX 99..104
FT /evidence="ECO:0007829|PDB:3P12"
FT HELIX 105..107
FT /evidence="ECO:0007829|PDB:3P12"
FT STRAND 111..116
FT /evidence="ECO:0007829|PDB:3P12"
FT STRAND 126..130
FT /evidence="ECO:0007829|PDB:3P12"
SQ SEQUENCE 134 AA; 15165 MW; 517EC13797ECF56D CRC64;
MKKSAVLNEH ISKAIATIGH FDLLTINDAG MPIPNDHRRI DLAVTKNLPR FIDVLATVLE
EMEIQKIYLA EEIKEHNPTQ LQQIKQLISS EIEIIFIPHE EMKSNLAHPL NKGNIRTGET
TPYSNIALES NVTF
