ID   RBSR_ECO57              Reviewed;         330 AA.
AC   P0ACQ2; P25551;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Ribose operon repressor;
GN   Name=rbsR; OrderedLocusNames=Z5254, ECs4695;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Transcriptional repressor for the ribose rbsDACBK operon.
CC       RbsR binds to a region of perfect dyad symmetry spanning the rbs operon
CC       transcriptional start site. The affinity for the rbs operator is
CC       reduced by addition of ribose, consistent with ribose being the inducer
CC       of the operon (By similarity). {ECO:0000250}.
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DR   EMBL; AE005174; AAG58956.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB38118.1; -; Genomic_DNA.
DR   PIR; G91215; G91215.
DR   PIR; H86061; H86061.
DR   RefSeq; NP_312722.1; NC_002695.1.
DR   RefSeq; WP_000224470.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ACQ2; -.
DR   SMR; P0ACQ2; -.
DR   STRING; 155864.EDL933_5083; -.
DR   EnsemblBacteria; AAG58956; AAG58956; Z5254.
DR   EnsemblBacteria; BAB38118; BAB38118; ECs_4695.
DR   GeneID; 58463882; -.
DR   GeneID; 915322; -.
DR   KEGG; ece:Z5254; -.
DR   KEGG; ecs:ECs_4695; -.
DR   PATRIC; fig|386585.9.peg.4901; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_2_6; -.
DR   OMA; IMQRYPS; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..330
FT                   /note="Ribose operon repressor"
FT                   /id="PRO_0000107986"
FT   DOMAIN          2..56
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   330 AA;  36612 MW;  AA651205A4109CAE CRC64;
     MATMKDVARL AGVSTSTVSH VINKDRFVSE AITAKVEAAI KELNYAPSAL ARSLKLNQTH
     TIGMLITAST NPFYSELVRG VERSCFERGY SLVLCNTEGD EQRMNRNLET LMQKRVDGLL
     LLCTETHQPS REIMQRYPTV PTVMMDWAPF DGDSDLIQDN SLLGGDLATQ YLIDKGHTRI
     ACITGPLDKT PARLRLEGYR AAMKRAGLNI PDGYEVTGDF EFNGGFDAMR QLLSHPLRPQ
     AVFTGNDAMA VGVYQALYQA ELQVPQDIAV IGYDDIELAS FMTPPLTTIH QPKDELGELA
     IDVLIHRITQ PTLQQQRLQL TPILMERGSA