ID   RBSR_SHIFL              Reviewed;         330 AA.
AC   P0ACQ3; P25551;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Ribose operon repressor;
GN   Name=rbsR; OrderedLocusNames=SF3836, S3931;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Transcriptional repressor for the ribose rbsDACBK operon.
CC       RbsR binds to a region of perfect dyad symmetry spanning the rbs operon
CC       transcriptional start site. The affinity for the rbs operator is
CC       reduced by addition of ribose, consistent with ribose being the inducer
CC       of the operon (By similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN45274.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAP18923.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005674; AAN45274.2; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014073; AAP18923.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_709567.2; NC_004337.2.
DR   RefSeq; WP_000224470.1; NZ_WPGW01000156.1.
DR   AlphaFoldDB; P0ACQ3; -.
DR   SMR; P0ACQ3; -.
DR   STRING; 198214.SF3836; -.
DR   EnsemblBacteria; AAN45274; AAN45274; SF3836.
DR   EnsemblBacteria; AAP18923; AAP18923; S3931.
DR   GeneID; 1026019; -.
DR   GeneID; 58463882; -.
DR   KEGG; sfl:SF3836; -.
DR   KEGG; sfx:S3931; -.
DR   PATRIC; fig|198214.7.peg.4527; -.
DR   HOGENOM; CLU_037628_6_2_6; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   PRINTS; PR00036; HTHLACI.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..330
FT                   /note="Ribose operon repressor"
FT                   /id="PRO_0000107988"
FT   DOMAIN          2..56
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   330 AA;  36612 MW;  AA651205A4109CAE CRC64;
     MATMKDVARL AGVSTSTVSH VINKDRFVSE AITAKVEAAI KELNYAPSAL ARSLKLNQTH
     TIGMLITAST NPFYSELVRG VERSCFERGY SLVLCNTEGD EQRMNRNLET LMQKRVDGLL
     LLCTETHQPS REIMQRYPTV PTVMMDWAPF DGDSDLIQDN SLLGGDLATQ YLIDKGHTRI
     ACITGPLDKT PARLRLEGYR AAMKRAGLNI PDGYEVTGDF EFNGGFDAMR QLLSHPLRPQ
     AVFTGNDAMA VGVYQALYQA ELQVPQDIAV IGYDDIELAS FMTPPLTTIH QPKDELGELA
     IDVLIHRITQ PTLQQQRLQL TPILMERGSA