ID   RBTN1_DANRE             Reviewed;         155 AA.
AC   Q8JFQ2;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Rhombotin-1;
DE   AltName: Full=LIM domain only protein 1;
DE            Short=LMO-1;
GN   Name=lmo1 {ECO:0000312|ZFIN:ZDB-GENE-021115-6};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAN03595.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAN03595.1};
RX   PubMed=15827121; DOI=10.1073/pnas.0408708102;
RA   Langenau D.M., Feng H., Berghmans S., Kanki J.P., Kutok J.L., Look A.T.;
RT   "Cre/lox-regulated transgenic zebrafish model with conditional myc-induced
RT   T cell acute lymphoblastic leukemia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:6068-6073(2005).
RN   [2] {ECO:0000312|EMBL:AAH92690.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:AAH92690.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in gene regulation within neural lineage
CC       cells potentially by direct DNA binding or by binding to other
CC       transcription factors. {ECO:0000250|UniProtKB:Q924W9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q924W9}.
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DR   EMBL; AF398514; AAN03595.1; -; mRNA.
DR   EMBL; BC092690; AAH92690.1; -; mRNA.
DR   RefSeq; NP_775326.1; NM_173219.3.
DR   AlphaFoldDB; Q8JFQ2; -.
DR   SMR; Q8JFQ2; -.
DR   STRING; 7955.ENSDARP00000044207; -.
DR   PaxDb; Q8JFQ2; -.
DR   Ensembl; ENSDART00000044208; ENSDARP00000044207; ENSDARG00000034504.
DR   GeneID; 280646; -.
DR   KEGG; dre:280646; -.
DR   CTD; 4004; -.
DR   ZFIN; ZDB-GENE-021115-6; lmo1.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000153908; -.
DR   HOGENOM; CLU_001357_7_1_1; -.
DR   InParanoid; Q8JFQ2; -.
DR   OMA; CPRTGRP; -.
DR   OrthoDB; 1307952at2759; -.
DR   PhylomeDB; Q8JFQ2; -.
DR   TreeFam; TF351071; -.
DR   Reactome; R-DRE-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR   PRO; PR:Q8JFQ2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000034504; Expressed in brain and 34 other tissues.
DR   ExpressionAtlas; Q8JFQ2; baseline and differential.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc.
FT   CHAIN           1..155
FT                   /note="Rhombotin-1"
FT                   /id="PRO_0000318109"
FT   DOMAIN          21..83
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          85..147
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ   SEQUENCE   155 AA;  17711 MW;  2ACF262B3B1A8AFA CRC64;
     MVLDKEEGVP MLSVQPKGKQ KGCAGCNRKI KDRYLLKALD KYWHEDCLKC ACCDCRLGEV
     GSTLYTKANL ILCRRDYLRL FGTTGNCAAC SKLIPAFEMV MRARDNVYHL DCFACQLCNQ
     RFCVGDKFFL KNNMILCQMD YEEGQLNGSF ETQVQ