RBTN1_HUMAN
ID RBTN1_HUMAN Reviewed; 156 AA.
AC P25800; E9PSF5; Q4VBC5; Q8IXR0;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 185.
DE RecName: Full=Rhombotin-1;
DE AltName: Full=Cysteine-rich protein TTG-1;
DE AltName: Full=LIM domain only protein 1;
DE Short=LMO-1;
DE AltName: Full=T-cell translocation protein 1;
GN Name=LMO1; Synonyms=RBTN1, RHOM1, TTG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=2501659; DOI=10.1128/mcb.9.5.2124-2132.1989;
RA McGuire E.A., Hockett R.D., Pollock K.M., Bartholdi M.F., O'Brien S.J.,
RA Korsmeyer S.J.;
RT "The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line
RT activates multiple transcripts, including Ttg-1, a gene encoding a
RT potential zinc finger protein.";
RL Mol. Cell. Biol. 9:2124-2132(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=2311586; DOI=10.1002/j.1460-2075.1990.tb08183.x;
RA Boehm T., Greenberg J.M., Buluwela L., Lavenir I., Forster A.,
RA Rabbitts T.H.;
RT "An unusual structure of a putative T cell oncogene which allows production
RT of similar proteins from distinct mRNAs.";
RL EMBO J. 9:857-868(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=1703797;
RA McGuire E.A., Davis A.R., Korsmeyer S.J.;
RT "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally
RT expressed in neural lineage cells.";
RL Blood 77:599-606(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RX PubMed=11528126; DOI=10.1159/000056998;
RA Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S.,
RA Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.;
RT "Comparative architectural aspects of regions of conserved synteny on human
RT chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and
RT LMO1).";
RL Cytogenet. Cell Genet. 93:277-283(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=2052354;
RA Boehm T., Spillantini M.G., Sofroniew M.V., Surani M.A., Rabbitts T.H.;
RT "Developmentally regulated and tissue specific expression of mRNAs encoding
RT the two alternative forms of the LIM domain oncogene rhombotin: evidence
RT for thymus expression.";
RL Oncogene 6:695-703(1991).
CC -!- FUNCTION: May be involved in gene regulation within neural lineage
CC cells potentially by direct DNA binding or by binding to other
CC transcription factors. {ECO:0000269|PubMed:1703797}.
CC -!- INTERACTION:
CC P25800; Q8IZP0-5: ABI1; NbExp=3; IntAct=EBI-8639312, EBI-11743294;
CC P25800; Q9NYB9-2: ABI2; NbExp=8; IntAct=EBI-8639312, EBI-11096309;
CC P25800; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-8639312, EBI-10173507;
CC P25800; Q6PJH3: AKAP9; NbExp=3; IntAct=EBI-8639312, EBI-11745576;
CC P25800; Q7Z591: AKNA; NbExp=3; IntAct=EBI-8639312, EBI-2799297;
CC P25800; Q8WXK1: ASB15; NbExp=3; IntAct=EBI-8639312, EBI-12809012;
CC P25800; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-8639312, EBI-11524452;
CC P25800; O75934: BCAS2; NbExp=3; IntAct=EBI-8639312, EBI-1050106;
CC P25800; Q9H165-2: BCL11A; NbExp=3; IntAct=EBI-8639312, EBI-10183342;
CC P25800; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-8639312, EBI-11519926;
CC P25800; Q86UB2: BIVM; NbExp=3; IntAct=EBI-8639312, EBI-12191873;
CC P25800; Q9H2G9: BLZF1; NbExp=7; IntAct=EBI-8639312, EBI-2548012;
CC P25800; Q6ZN30: BNC2; NbExp=3; IntAct=EBI-8639312, EBI-6115618;
CC P25800; Q13895: BYSL; NbExp=3; IntAct=EBI-8639312, EBI-358049;
CC P25800; Q9H257: CARD9; NbExp=3; IntAct=EBI-8639312, EBI-751319;
CC P25800; Q8NA61: CBY2; NbExp=3; IntAct=EBI-8639312, EBI-741724;
CC P25800; A6NC98: CCDC88B; NbExp=3; IntAct=EBI-8639312, EBI-347573;
CC P25800; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-8639312, EBI-5278764;
CC P25800; O14627: CDX4; NbExp=3; IntAct=EBI-8639312, EBI-10181162;
CC P25800; Q96L14: CEP170P1; NbExp=3; IntAct=EBI-8639312, EBI-743488;
CC P25800; Q9C0F1: CEP44; NbExp=3; IntAct=EBI-8639312, EBI-744115;
CC P25800; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-8639312, EBI-1104570;
CC P25800; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-8639312, EBI-743375;
CC P25800; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-8639312, EBI-742054;
CC P25800; O60447: EVI5; NbExp=3; IntAct=EBI-8639312, EBI-852291;
CC P25800; Q8IX29: FBXO16; NbExp=3; IntAct=EBI-8639312, EBI-12063229;
CC P25800; Q06547: GABPB1; NbExp=4; IntAct=EBI-8639312, EBI-618165;
CC P25800; O95995: GAS8; NbExp=3; IntAct=EBI-8639312, EBI-1052570;
CC P25800; Q08379: GOLGA2; NbExp=6; IntAct=EBI-8639312, EBI-618309;
CC P25800; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-8639312, EBI-11959863;
CC P25800; Q7Z353: HDX; NbExp=3; IntAct=EBI-8639312, EBI-1052734;
CC P25800; O14964: HGS; NbExp=3; IntAct=EBI-8639312, EBI-740220;
CC P25800; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-8639312, EBI-2549423;
CC P25800; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-8639312, EBI-740641;
CC P25800; P31943: HNRNPH1; NbExp=3; IntAct=EBI-8639312, EBI-351590;
CC P25800; P52272: HNRNPM; NbExp=3; IntAct=EBI-8639312, EBI-486809;
CC P25800; Q16082: HSPB2; NbExp=3; IntAct=EBI-8639312, EBI-739395;
CC P25800; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-8639312, EBI-11522367;
CC P25800; Q9UKT9: IKZF3; NbExp=4; IntAct=EBI-8639312, EBI-747204;
CC P25800; Q9ULR0: ISY1; NbExp=3; IntAct=EBI-8639312, EBI-2557660;
CC P25800; Q63ZY3: KANK2; NbExp=9; IntAct=EBI-8639312, EBI-2556193;
CC P25800; Q719H9: KCTD1; NbExp=3; IntAct=EBI-8639312, EBI-9027502;
CC P25800; Q86T90: KIAA1328; NbExp=3; IntAct=EBI-8639312, EBI-3437878;
CC P25800; Q5JUW0-3: KRBOX4; NbExp=5; IntAct=EBI-8639312, EBI-12893625;
CC P25800; P08779: KRT16; NbExp=3; IntAct=EBI-8639312, EBI-356410;
CC P25800; Q6A162: KRT40; NbExp=3; IntAct=EBI-8639312, EBI-10171697;
CC P25800; O95678: KRT75; NbExp=3; IntAct=EBI-8639312, EBI-2949715;
CC P25800; Q86U70: LDB1; NbExp=5; IntAct=EBI-8639312, EBI-677177;
CC P25800; Q86U70-2: LDB1; NbExp=6; IntAct=EBI-8639312, EBI-11979761;
CC P25800; O43679: LDB2; NbExp=3; IntAct=EBI-8639312, EBI-2865580;
CC P25800; O60711: LPXN; NbExp=7; IntAct=EBI-8639312, EBI-744222;
CC P25800; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-8639312, EBI-1216080;
CC P25800; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-8639312, EBI-741037;
CC P25800; Q9Y6D9: MAD1L1; NbExp=3; IntAct=EBI-8639312, EBI-742610;
CC P25800; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-8639312, EBI-12516603;
CC P25800; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-8639312, EBI-16439278;
CC P25800; Q8IVT2: MISP; NbExp=8; IntAct=EBI-8639312, EBI-2555085;
CC P25800; Q4VC12: MSS51; NbExp=3; IntAct=EBI-8639312, EBI-11599933;
CC P25800; Q9UJ70-2: NAGK; NbExp=5; IntAct=EBI-8639312, EBI-11526455;
CC P25800; O95182: NDUFA7; NbExp=3; IntAct=EBI-8639312, EBI-721471;
CC P25800; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-8639312, EBI-741158;
CC P25800; Q86Y26: NUTM1; NbExp=3; IntAct=EBI-8639312, EBI-10178410;
CC P25800; Q8IXK0: PHC2; NbExp=3; IntAct=EBI-8639312, EBI-713786;
CC P25800; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-8639312, EBI-79165;
CC P25800; Q9BT43: POLR3GL; NbExp=3; IntAct=EBI-8639312, EBI-2855862;
CC P25800; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-8639312, EBI-1105153;
CC P25800; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-8639312, EBI-11320284;
CC P25800; P20618: PSMB1; NbExp=3; IntAct=EBI-8639312, EBI-372273;
CC P25800; P26045: PTPN3; NbExp=6; IntAct=EBI-8639312, EBI-1047946;
CC P25800; P49023-2: PXN; NbExp=5; IntAct=EBI-8639312, EBI-11954250;
CC P25800; Q99708-2: RBBP8; NbExp=3; IntAct=EBI-8639312, EBI-10203615;
CC P25800; Q15293: RCN1; NbExp=3; IntAct=EBI-8639312, EBI-948278;
CC P25800; Q04864: REL; NbExp=3; IntAct=EBI-8639312, EBI-307352;
CC P25800; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-8639312, EBI-3957636;
CC P25800; P35711: SOX5; NbExp=3; IntAct=EBI-8639312, EBI-3505701;
CC P25800; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-8639312, EBI-742688;
CC P25800; Q96C24: SYTL4; NbExp=3; IntAct=EBI-8639312, EBI-747142;
CC P25800; O75478: TADA2A; NbExp=3; IntAct=EBI-8639312, EBI-742268;
CC P25800; Q5VWN6-2: TASOR2; NbExp=3; IntAct=EBI-8639312, EBI-10172380;
CC P25800; P15884: TCF4; NbExp=3; IntAct=EBI-8639312, EBI-533224;
CC P25800; Q8TDR4: TCP10L; NbExp=3; IntAct=EBI-8639312, EBI-3923210;
CC P25800; Q9UBB9: TFIP11; NbExp=7; IntAct=EBI-8639312, EBI-1105213;
CC P25800; Q08117: TLE5; NbExp=3; IntAct=EBI-8639312, EBI-717810;
CC P25800; P14373: TRIM27; NbExp=3; IntAct=EBI-8639312, EBI-719493;
CC P25800; Q9UPQ4-2: TRIM35; NbExp=3; IntAct=EBI-8639312, EBI-17716262;
CC P25800; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-8639312, EBI-2130429;
CC P25800; Q9Y3Q8: TSC22D4; NbExp=3; IntAct=EBI-8639312, EBI-739485;
CC P25800; Q9NUQ7: UFSP2; NbExp=3; IntAct=EBI-8639312, EBI-11153325;
CC P25800; Q8TAS1-2: UHMK1; NbExp=3; IntAct=EBI-8639312, EBI-12157345;
CC P25800; Q9H9P5-5: UNKL; NbExp=4; IntAct=EBI-8639312, EBI-12817837;
CC P25800; Q9BVJ6: UTP14A; NbExp=3; IntAct=EBI-8639312, EBI-473284;
CC P25800; P61758: VBP1; NbExp=3; IntAct=EBI-8639312, EBI-357430;
CC P25800; O43298: ZBTB43; NbExp=7; IntAct=EBI-8639312, EBI-740718;
CC P25800; Q8NAP8: ZBTB8B; NbExp=3; IntAct=EBI-8639312, EBI-17494306;
CC P25800; Q6PEW1: ZCCHC12; NbExp=3; IntAct=EBI-8639312, EBI-748373;
CC P25800; Q8TF47: ZFP90; NbExp=3; IntAct=EBI-8639312, EBI-11419867;
CC P25800; P52747: ZNF143; NbExp=3; IntAct=EBI-8639312, EBI-2849334;
CC P25800; Q13360-2: ZNF177; NbExp=3; IntAct=EBI-8639312, EBI-12272076;
CC P25800; P17023: ZNF19; NbExp=3; IntAct=EBI-8639312, EBI-12884200;
CC P25800; Q9P2Y4: ZNF219; NbExp=3; IntAct=EBI-8639312, EBI-3937106;
CC P25800; P17028: ZNF24; NbExp=5; IntAct=EBI-8639312, EBI-707773;
CC P25800; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-8639312, EBI-740727;
CC P25800; Q14592: ZNF460; NbExp=3; IntAct=EBI-8639312, EBI-2555738;
CC P25800; Q8NB15: ZNF511; NbExp=6; IntAct=EBI-8639312, EBI-10269136;
CC P25800; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-8639312, EBI-11035148;
CC P25800; Q6ZNG0: ZNF620; NbExp=3; IntAct=EBI-8639312, EBI-4395669;
CC P25800; Q96N77-2: ZNF641; NbExp=3; IntAct=EBI-8639312, EBI-12939666;
CC P25800; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-8639312, EBI-4395732;
CC P25800; P36508: ZNF76; NbExp=3; IntAct=EBI-8639312, EBI-7254550;
CC P25800; P51523: ZNF84; NbExp=3; IntAct=EBI-8639312, EBI-2849074;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P25800-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P25800-2; Sequence=VSP_046664;
CC -!- TISSUE SPECIFICITY: Expressed mainly in the central nervous. Low level
CC of expression in other tissues including thymus.
CC {ECO:0000269|PubMed:2052354}.
CC -!- DISEASE: Note=A chromosomal aberration involving LMO1 may be a cause of
CC a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation
CC t(11,14)(p15;q11) with TCRD.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH39512.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/LMO1ID33ch11p15.html";
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DR EMBL; M26682; AAA36819.1; -; mRNA.
DR EMBL; AJ277662; CAC14587.1; -; Genomic_DNA.
DR EMBL; AC091013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039512; AAH39512.1; ALT_INIT; mRNA.
DR EMBL; BC069673; AAH69673.1; -; mRNA.
DR EMBL; BC069752; AAH69752.1; -; mRNA.
DR EMBL; BC069793; AAH69793.1; -; mRNA.
DR EMBL; BC096056; AAH96056.1; -; mRNA.
DR EMBL; BC096057; AAH96057.1; -; mRNA.
DR CCDS; CCDS44534.1; -. [P25800-1]
DR CCDS; CCDS58118.1; -. [P25800-2]
DR PIR; A32795; A32795.
DR RefSeq; NP_001257357.1; NM_001270428.1. [P25800-2]
DR RefSeq; NP_002306.1; NM_002315.2. [P25800-1]
DR AlphaFoldDB; P25800; -.
DR SMR; P25800; -.
DR BioGRID; 110190; 151.
DR IntAct; P25800; 111.
DR MINT; P25800; -.
DR STRING; 9606.ENSP00000338207; -.
DR iPTMnet; P25800; -.
DR PhosphoSitePlus; P25800; -.
DR BioMuta; LMO1; -.
DR DMDM; 132532; -.
DR MassIVE; P25800; -.
DR MaxQB; P25800; -.
DR PaxDb; P25800; -.
DR PeptideAtlas; P25800; -.
DR PRIDE; P25800; -.
DR ProteomicsDB; 23606; -.
DR ProteomicsDB; 54297; -. [P25800-1]
DR Antibodypedia; 5875; 162 antibodies from 25 providers.
DR DNASU; 4004; -.
DR Ensembl; ENST00000335790.8; ENSP00000338207.3; ENSG00000166407.14. [P25800-1]
DR Ensembl; ENST00000428101.6; ENSP00000404538.2; ENSG00000166407.14. [P25800-2]
DR GeneID; 4004; -.
DR KEGG; hsa:4004; -.
DR MANE-Select; ENST00000335790.8; ENSP00000338207.3; NM_002315.3; NP_002306.1.
DR UCSC; uc001mgg.3; human. [P25800-1]
DR CTD; 4004; -.
DR DisGeNET; 4004; -.
DR GeneCards; LMO1; -.
DR HGNC; HGNC:6641; LMO1.
DR HPA; ENSG00000166407; Tissue enhanced (brain, skeletal muscle, tongue).
DR MalaCards; LMO1; -.
DR MIM; 186921; gene+phenotype.
DR neXtProt; NX_P25800; -.
DR OpenTargets; ENSG00000166407; -.
DR Orphanet; 635; Neuroblastoma.
DR PharmGKB; PA30407; -.
DR VEuPathDB; HostDB:ENSG00000166407; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000153908; -.
DR InParanoid; P25800; -.
DR OMA; CPRTGRP; -.
DR OrthoDB; 1307952at2759; -.
DR PhylomeDB; P25800; -.
DR TreeFam; TF351071; -.
DR PathwayCommons; P25800; -.
DR Reactome; R-HSA-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR SignaLink; P25800; -.
DR SIGNOR; P25800; -.
DR BioGRID-ORCS; 4004; 18 hits in 1074 CRISPR screens.
DR ChiTaRS; LMO1; human.
DR GeneWiki; LMO1; -.
DR GenomeRNAi; 4004; -.
DR Pharos; P25800; Tbio.
DR PRO; PR:P25800; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P25800; protein.
DR Bgee; ENSG00000166407; Expressed in vastus lateralis and 106 other tissues.
DR ExpressionAtlas; P25800; baseline and differential.
DR Genevisible; P25800; HS.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:BHF-UCL.
DR GO; GO:0046013; P:regulation of T cell homeostatic proliferation; IEA:Ensembl.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00132; LIM; 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromosomal rearrangement; LIM domain; Metal-binding;
KW Nucleus; Proto-oncogene; Reference proteome; Repeat; Zinc.
FT CHAIN 1..156
FT /note="Rhombotin-1"
FT /id="PRO_0000075894"
FT DOMAIN 24..83
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 88..147
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT VAR_SEQ 1..9
FT /note="MMVLDKEDG -> MVLDQEDG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_046664"
SQ SEQUENCE 156 AA; 17828 MW; 6BAFBE1F870CCAAC CRC64;
MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK CACCDCRLGE
VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM VMRARDNVYH LDCFACQLCN
QRFCVGDKFF LKNNMILCQM DYEEGQLNGT FESQVQ