RBTN1_MOUSE
ID RBTN1_MOUSE Reviewed; 156 AA.
AC Q924W9;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Rhombotin-1;
DE AltName: Full=Cysteine-rich protein TTG-1;
DE AltName: Full=LIM domain only protein 1;
DE Short=LMO-1;
DE AltName: Full=T-cell translocation protein 1;
GN Name=Lmo1; Synonyms=Rbtn1, Rhom1, Ttg1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11528126; DOI=10.1159/000056998;
RA Cichutek A., Brueckmann T., Seipel B., Hauser H., Schlaubitz S.,
RA Prawitt D., Hankeln T., Schmidt E.R., Winterpacht A., Zabel B.U.;
RT "Comparative architectural aspects of regions of conserved synteny on human
RT chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and
RT LMO1).";
RL Cytogenet. Cell Genet. 93:277-283(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=1703797;
RA McGuire E.A., Davis A.R., Korsmeyer S.J.;
RT "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally
RT expressed in neural lineage cells.";
RL Blood 77:599-606(1991).
CC -!- FUNCTION: May be involved in gene regulation within neural lineage
CC cells potentially by direct DNA binding or by binding to other
CC transcription factors. {ECO:0000269|PubMed:1703797}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1703797}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain and not in the thymus.
CC {ECO:0000269|PubMed:1703797}.
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DR EMBL; AJ296304; CAC39310.1; -; Genomic_DNA.
DR EMBL; BC053074; AAH53074.1; -; mRNA.
DR CCDS; CCDS40080.1; -.
DR RefSeq; NP_001289134.1; NM_001302205.1.
DR RefSeq; NP_001289135.1; NM_001302206.1.
DR RefSeq; NP_476514.1; NM_057173.3.
DR RefSeq; XP_006507258.1; XM_006507195.3.
DR AlphaFoldDB; Q924W9; -.
DR SMR; Q924W9; -.
DR BioGRID; 224887; 4.
DR IntAct; Q924W9; 4.
DR STRING; 10090.ENSMUSP00000037079; -.
DR PhosphoSitePlus; Q924W9; -.
DR MaxQB; Q924W9; -.
DR PaxDb; Q924W9; -.
DR PRIDE; Q924W9; -.
DR ProteomicsDB; 254901; -.
DR Antibodypedia; 5875; 162 antibodies from 25 providers.
DR DNASU; 109594; -.
DR Ensembl; ENSMUST00000036992; ENSMUSP00000037079; ENSMUSG00000036111.
DR GeneID; 109594; -.
DR KEGG; mmu:109594; -.
DR UCSC; uc009jdk.2; mouse.
DR CTD; 4004; -.
DR MGI; MGI:102812; Lmo1.
DR VEuPathDB; HostDB:ENSMUSG00000036111; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000153908; -.
DR HOGENOM; CLU_001357_7_1_1; -.
DR InParanoid; Q924W9; -.
DR OMA; CPRTGRP; -.
DR OrthoDB; 1307952at2759; -.
DR PhylomeDB; Q924W9; -.
DR TreeFam; TF351071; -.
DR Reactome; R-MMU-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR BioGRID-ORCS; 109594; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Lmo1; mouse.
DR PRO; PR:Q924W9; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q924W9; protein.
DR Bgee; ENSMUSG00000036111; Expressed in medial ganglionic eminence and 208 other tissues.
DR ExpressionAtlas; Q924W9; baseline and differential.
DR Genevisible; Q924W9; MM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:MGI.
DR GO; GO:0046013; P:regulation of T cell homeostatic proliferation; IDA:MGI.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00132; LIM; 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc.
FT CHAIN 1..156
FT /note="Rhombotin-1"
FT /id="PRO_0000075895"
FT DOMAIN 22..84
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 86..148
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ SEQUENCE 156 AA; 17805 MW; 7AAEB122870CCAAC CRC64;
MMVLDKEDGV PMLSVQPKGK QKGCAGCNRK IKDRYLLKAL DKYWHEDCLK CACCDCRLGE
VGSTLYTKAN LILCRRDYLR LFGTTGNCAA CSKLIPAFEM VMRARDNVYH LDCFACQLCN
QRFCVGDKFF LKNNMILCQV DYEEGHLNGT FESQVQ
