ID   RBTN2_BOVIN             Reviewed;         158 AA.
AC   Q1LZ94;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Rhombotin-2;
DE   AltName: Full=LIM domain only protein 2;
DE            Short=LMO-2;
GN   Name=LMO2; Synonyms=RBTN2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts with TAL1/SCL to regulate red blood cell development.
CC       Also acts with LDB1 to maintain erythroid precursors in an immature
CC       state.
CC   -!- SUBUNIT: Interacts via its LIM domains with ELF2 and LDB1. Interacts
CC       with BEX2 and KDM5A. Also interacts with basic helix-loop-helix protein
CC       TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DOMAIN: The second LIM zinc-binding domain interacts with KDM5A.
CC       {ECO:0000250}.
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DR   EMBL; BC116134; AAI16135.1; -; mRNA.
DR   RefSeq; NP_001069820.1; NM_001076352.1.
DR   RefSeq; XP_005216448.1; XM_005216391.3.
DR   AlphaFoldDB; Q1LZ94; -.
DR   BMRB; Q1LZ94; -.
DR   SMR; Q1LZ94; -.
DR   STRING; 9913.ENSBTAP00000009126; -.
DR   PaxDb; Q1LZ94; -.
DR   GeneID; 614876; -.
DR   KEGG; bta:614876; -.
DR   CTD; 4005; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   HOGENOM; CLU_001357_3_1_1; -.
DR   InParanoid; Q1LZ94; -.
DR   OrthoDB; 1307952at2759; -.
DR   TreeFam; TF351071; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   LIM domain; Metal-binding; Nucleus; Reference proteome; Repeat; Zinc.
FT   CHAIN           1..158
FT                   /note="Rhombotin-2"
FT                   /id="PRO_0000269567"
FT   DOMAIN          30..89
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          94..153
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ   SEQUENCE   158 AA;  18376 MW;  B28AE42505579890 CRC64;
     MSSAIERKSL DPSEEPVDEV LQMPPSLLTC GGCQQNIGDR YFLKAIDQYW HEDCLSCDLC
     GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR IRAYEMTMRV KDKVYHLECF
     KCAACQKHFC VGDRYLLINS DIVCEQDIYE WTKINGMI