RBTN2_HUMAN
ID RBTN2_HUMAN Reviewed; 158 AA.
AC P25791; Q9HD58;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 202.
DE RecName: Full=Rhombotin-2;
DE AltName: Full=Cysteine-rich protein TTG-2;
DE AltName: Full=LIM domain only protein 2;
DE Short=LMO-2;
DE AltName: Full=T-cell translocation protein 2;
GN Name=LMO2; Synonyms=RBTN2, RBTNL1, RHOM2, TTG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND INVOLVEMENT IN T-CELL ACUTE
RP LYMPHOBLASTIC LEUKEMIA.
RC TISSUE=Kidney;
RX PubMed=1923511;
RA Royer-Pokora B., Loos L., Ludwig W.D.;
RT "TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is
RT overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11).";
RL Oncogene 6:1887-1893(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 15-158 (ISOFORM 1).
RC TISSUE=Kidney;
RA Zhu T.;
RT "New 5'-end of LMO2 (TTG-2/RBTN2).";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP INTERACTION WITH KDM5A.
RX PubMed=9129143; DOI=10.1038/sj.onc.1200988;
RA Mao S., Neale G.A.M., Goorha R.M.;
RT "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein
RT 2.";
RL Oncogene 14:1531-1539(1997).
RN [5]
RP INTERACTION WITH BEX2.
RX PubMed=16314316; DOI=10.1093/nar/gki964;
RA Han C., Liu H., Liu J., Yin K., Xie Y., Shen X., Wang Y., Yuan J.,
RA Qiang B., Liu Y.-J., Peng X.;
RT "Human Bex2 interacts with LMO2 and regulates the transcriptional activity
RT of a novel DNA-binding complex.";
RL Nucleic Acids Res. 33:6555-6565(2005).
CC -!- FUNCTION: Acts with TAL1/SCL to regulate red blood cell development.
CC Also acts with LDB1 to maintain erythroid precursors in an immature
CC state.
CC -!- SUBUNIT: Interacts via its LIM domains with ELF2 and LDB1. Also
CC interacts with basic helix-loop-helix protein TAL1/SCL and can assemble
CC in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with
CC BEX2 and KDM5A. {ECO:0000250, ECO:0000269|PubMed:16314316,
CC ECO:0000269|PubMed:9129143}.
CC -!- INTERACTION:
CC P25791; Q9NYB9: ABI2; NbExp=5; IntAct=EBI-739696, EBI-743598;
CC P25791; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-739696, EBI-10173507;
CC P25791; Q6RW13: AGTRAP; NbExp=3; IntAct=EBI-739696, EBI-741181;
CC P25791; Q13155: AIMP2; NbExp=3; IntAct=EBI-739696, EBI-745226;
CC P25791; Q8N9N5: BANP; NbExp=3; IntAct=EBI-739696, EBI-744695;
CC P25791; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-739696, EBI-2548012;
CC P25791; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-739696, EBI-946029;
CC P25791; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-739696, EBI-739580;
CC P25791; Q8NA61: CBY2; NbExp=3; IntAct=EBI-739696, EBI-741724;
CC P25791; O14627: CDX4; NbExp=3; IntAct=EBI-739696, EBI-10181162;
CC P25791; Q8NHS4: CLHC1; NbExp=3; IntAct=EBI-739696, EBI-10203156;
CC P25791; Q96DZ9: CMTM5; NbExp=3; IntAct=EBI-739696, EBI-2548702;
CC P25791; Q8NFT6: DBF4B; NbExp=3; IntAct=EBI-739696, EBI-749662;
CC P25791; P35638-2: DDIT3; NbExp=3; IntAct=EBI-739696, EBI-10173632;
CC P25791; Q14919: DRAP1; NbExp=3; IntAct=EBI-739696, EBI-712941;
CC P25791; Q13643: FHL3; NbExp=3; IntAct=EBI-739696, EBI-741101;
CC P25791; P14136: GFAP; NbExp=3; IntAct=EBI-739696, EBI-744302;
CC P25791; Q08379: GOLGA2; NbExp=3; IntAct=EBI-739696, EBI-618309;
CC P25791; P62993: GRB2; NbExp=3; IntAct=EBI-739696, EBI-401755;
CC P25791; P07910: HNRNPC; NbExp=3; IntAct=EBI-739696, EBI-357966;
CC P25791; P52272: HNRNPM; NbExp=4; IntAct=EBI-739696, EBI-486809;
CC P25791; Q9UJC3: HOOK1; NbExp=3; IntAct=EBI-739696, EBI-746704;
CC P25791; Q96FT9: IFT43; NbExp=3; IntAct=EBI-739696, EBI-10189681;
CC P25791; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-739696, EBI-8638439;
CC P25791; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-739696, EBI-747204;
CC P25791; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-739696, EBI-2556193;
CC P25791; P19012: KRT15; NbExp=3; IntAct=EBI-739696, EBI-739566;
CC P25791; Q6A162: KRT40; NbExp=3; IntAct=EBI-739696, EBI-10171697;
CC P25791; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-739696, EBI-10172290;
CC P25791; Q86U70: LDB1; NbExp=6; IntAct=EBI-739696, EBI-677177;
CC P25791; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-739696, EBI-741037;
CC P25791; P43361: MAGEA8; NbExp=3; IntAct=EBI-739696, EBI-10182930;
CC P25791; Q15691: MAPRE1; NbExp=6; IntAct=EBI-739696, EBI-1004115;
CC P25791; Q15555: MAPRE2; NbExp=5; IntAct=EBI-739696, EBI-739717;
CC P25791; Q9UPY8: MAPRE3; NbExp=5; IntAct=EBI-739696, EBI-726739;
CC P25791; Q9NS73-5: MBIP; NbExp=3; IntAct=EBI-739696, EBI-10182361;
CC P25791; Q96HT8: MRFAP1L1; NbExp=3; IntAct=EBI-739696, EBI-748896;
CC P25791; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-739696, EBI-742948;
CC P25791; Q92802: N4BP2L2; NbExp=3; IntAct=EBI-739696, EBI-2514973;
CC P25791; Q9GZT8: NIF3L1; NbExp=3; IntAct=EBI-739696, EBI-740897;
CC P25791; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-739696, EBI-945833;
CC P25791; P37198: NUP62; NbExp=3; IntAct=EBI-739696, EBI-347978;
CC P25791; Q86Y26: NUTM1; NbExp=3; IntAct=EBI-739696, EBI-10178410;
CC P25791; O76083: PDE9A; NbExp=3; IntAct=EBI-739696, EBI-742764;
CC P25791; Q8IXK0: PHC2; NbExp=4; IntAct=EBI-739696, EBI-713786;
CC P25791; Q13976: PRKG1; NbExp=4; IntAct=EBI-739696, EBI-3952014;
CC P25791; Q04864: REL; NbExp=3; IntAct=EBI-739696, EBI-307352;
CC P25791; Q04206: RELA; NbExp=3; IntAct=EBI-739696, EBI-73886;
CC P25791; Q6NUQ1: RINT1; NbExp=4; IntAct=EBI-739696, EBI-726876;
CC P25791; Q13464: ROCK1; NbExp=3; IntAct=EBI-739696, EBI-876651;
CC P25791; Q8IYX7: SAXO1; NbExp=4; IntAct=EBI-739696, EBI-3957636;
CC P25791; P63208: SKP1; NbExp=3; IntAct=EBI-739696, EBI-307486;
CC P25791; P35711: SOX5; NbExp=3; IntAct=EBI-739696, EBI-3505701;
CC P25791; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-739696, EBI-2212028;
CC P25791; P40763: STAT3; NbExp=3; IntAct=EBI-739696, EBI-518675;
CC P25791; P0C1Z6-2: TFPT; NbExp=3; IntAct=EBI-739696, EBI-10178002;
CC P25791; Q08117: TLE5; NbExp=3; IntAct=EBI-739696, EBI-717810;
CC P25791; P36406: TRIM23; NbExp=3; IntAct=EBI-739696, EBI-740098;
CC P25791; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-739696, EBI-2130429;
CC P25791; Q15654: TRIP6; NbExp=3; IntAct=EBI-739696, EBI-742327;
CC P25791; Q9Y3Q8: TSC22D4; NbExp=3; IntAct=EBI-739696, EBI-739485;
CC P25791; Q9NNX1: TUFT1; NbExp=3; IntAct=EBI-739696, EBI-2557363;
CC P25791; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-739696, EBI-10180829;
CC P25791; Q9NTW7: ZFP64; NbExp=3; IntAct=EBI-739696, EBI-711679;
CC P25791; P17028: ZNF24; NbExp=4; IntAct=EBI-739696, EBI-707773;
CC P25791-3; Q9NYB9-2: ABI2; NbExp=6; IntAct=EBI-11959475, EBI-11096309;
CC P25791-3; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11959475, EBI-10173507;
CC P25791-3; Q13155: AIMP2; NbExp=6; IntAct=EBI-11959475, EBI-745226;
CC P25791-3; Q12774: ARHGEF5; NbExp=3; IntAct=EBI-11959475, EBI-602199;
CC P25791-3; Q03989: ARID5A; NbExp=3; IntAct=EBI-11959475, EBI-948603;
CC P25791-3; A0A087WVE9: ARNT2; NbExp=3; IntAct=EBI-11959475, EBI-12808086;
CC P25791-3; O75934: BCAS2; NbExp=3; IntAct=EBI-11959475, EBI-1050106;
CC P25791-3; Q13895: BYSL; NbExp=3; IntAct=EBI-11959475, EBI-358049;
CC P25791-3; Q9NX04: C1orf109; NbExp=5; IntAct=EBI-11959475, EBI-8643161;
CC P25791-3; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11959475, EBI-9679045;
CC P25791-3; Q14919: DRAP1; NbExp=3; IntAct=EBI-11959475, EBI-712941;
CC P25791-3; Q8WWB3: DYDC1; NbExp=3; IntAct=EBI-11959475, EBI-740680;
CC P25791-3; Q5JVL4: EFHC1; NbExp=3; IntAct=EBI-11959475, EBI-743105;
CC P25791-3; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-11959475, EBI-2349927;
CC P25791-3; Q13541: EIF4EBP1; NbExp=3; IntAct=EBI-11959475, EBI-74090;
CC P25791-3; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-11959475, EBI-744099;
CC P25791-3; Q6NZ36-4: FAAP20; NbExp=3; IntAct=EBI-11959475, EBI-12013806;
CC P25791-3; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-11959475, EBI-745689;
CC P25791-3; Q86W67: FAM228A; NbExp=3; IntAct=EBI-11959475, EBI-12958227;
CC P25791-3; Q86YD7: FAM90A1; NbExp=5; IntAct=EBI-11959475, EBI-6658203;
CC P25791-3; Q5TD97: FHL5; NbExp=3; IntAct=EBI-11959475, EBI-750641;
CC P25791-3; O95995: GAS8; NbExp=3; IntAct=EBI-11959475, EBI-1052570;
CC P25791-3; Q9UKD1: GMEB2; NbExp=6; IntAct=EBI-11959475, EBI-948296;
CC P25791-3; Q9UQL6: HDAC5; NbExp=3; IntAct=EBI-11959475, EBI-715576;
CC P25791-3; P52272: HNRNPM; NbExp=3; IntAct=EBI-11959475, EBI-486809;
CC P25791-3; Q9UJC3: HOOK1; NbExp=3; IntAct=EBI-11959475, EBI-746704;
CC P25791-3; Q8NDH6-2: ICA1L; NbExp=3; IntAct=EBI-11959475, EBI-12141931;
CC P25791-3; Q96FT9-2: IFT43; NbExp=3; IntAct=EBI-11959475, EBI-11944538;
CC P25791-3; Q8IYA8: IHO1; NbExp=3; IntAct=EBI-11959475, EBI-8638439;
CC P25791-3; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-11959475, EBI-11522367;
CC P25791-3; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-11959475, EBI-747204;
CC P25791-3; Q0VD86: INCA1; NbExp=3; IntAct=EBI-11959475, EBI-6509505;
CC P25791-3; Q9ULR0: ISY1; NbExp=3; IntAct=EBI-11959475, EBI-2557660;
CC P25791-3; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-11959475, EBI-2556193;
CC P25791-3; Q674X7-2: KAZN; NbExp=3; IntAct=EBI-11959475, EBI-12024294;
CC P25791-3; O00139-1: KIF2A; NbExp=3; IntAct=EBI-11959475, EBI-12197879;
CC P25791-3; Q5T749: KPRP; NbExp=3; IntAct=EBI-11959475, EBI-10981970;
CC P25791-3; O76011: KRT34; NbExp=3; IntAct=EBI-11959475, EBI-1047093;
CC P25791-3; O95678: KRT75; NbExp=3; IntAct=EBI-11959475, EBI-2949715;
CC P25791-3; Q6KB66-2: KRT80; NbExp=5; IntAct=EBI-11959475, EBI-11999246;
CC P25791-3; Q86U70-2: LDB1; NbExp=7; IntAct=EBI-11959475, EBI-11979761;
CC P25791-3; O43679: LDB2; NbExp=5; IntAct=EBI-11959475, EBI-2865580;
CC P25791-3; O95751: LDOC1; NbExp=3; IntAct=EBI-11959475, EBI-740738;
CC P25791-3; P25791-3: LMO2; NbExp=3; IntAct=EBI-11959475, EBI-11959475;
CC P25791-3; P61968: LMO4; NbExp=3; IntAct=EBI-11959475, EBI-2798728;
CC P25791-3; Q0VAK6: LMOD3; NbExp=3; IntAct=EBI-11959475, EBI-23685399;
CC P25791-3; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-11959475, EBI-1216080;
CC P25791-3; Q15691: MAPRE1; NbExp=6; IntAct=EBI-11959475, EBI-1004115;
CC P25791-3; Q15555: MAPRE2; NbExp=7; IntAct=EBI-11959475, EBI-739717;
CC P25791-3; Q9UPY8: MAPRE3; NbExp=6; IntAct=EBI-11959475, EBI-726739;
CC P25791-3; Q8IVT2: MISP; NbExp=5; IntAct=EBI-11959475, EBI-2555085;
CC P25791-3; P26038: MSN; NbExp=3; IntAct=EBI-11959475, EBI-528768;
CC P25791-3; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-11959475, EBI-5662487;
CC P25791-3; Q9UHB4: NDOR1; NbExp=3; IntAct=EBI-11959475, EBI-10249760;
CC P25791-3; O14561: NDUFAB1; NbExp=3; IntAct=EBI-11959475, EBI-1246261;
CC P25791-3; P17568: NDUFB7; NbExp=3; IntAct=EBI-11959475, EBI-1246238;
CC P25791-3; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-11959475, EBI-10271199;
CC P25791-3; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-11959475, EBI-12025760;
CC P25791-3; Q6X4W1-2: NSMF; NbExp=3; IntAct=EBI-11959475, EBI-12028784;
CC P25791-3; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-11959475, EBI-741158;
CC P25791-3; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-11959475, EBI-11022007;
CC P25791-3; P55771: PAX9; NbExp=3; IntAct=EBI-11959475, EBI-12111000;
CC P25791-3; Q9BYU1: PBX4; NbExp=3; IntAct=EBI-11959475, EBI-10302990;
CC P25791-3; P62487: POLR2G; NbExp=4; IntAct=EBI-11959475, EBI-347928;
CC P25791-3; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-11959475, EBI-12000762;
CC P25791-3; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-11959475, EBI-11320284;
CC P25791-3; Q13976-2: PRKG1; NbExp=3; IntAct=EBI-11959475, EBI-4280187;
CC P25791-3; P25786: PSMA1; NbExp=3; IntAct=EBI-11959475, EBI-359352;
CC P25791-3; Q15293: RCN1; NbExp=3; IntAct=EBI-11959475, EBI-948278;
CC P25791-3; A6ZKI3: RTL8C; NbExp=3; IntAct=EBI-11959475, EBI-10174072;
CC P25791-3; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-11959475, EBI-6257312;
CC P25791-3; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-11959475, EBI-3957636;
CC P25791-3; Q96EQ0: SGTB; NbExp=3; IntAct=EBI-11959475, EBI-744081;
CC P25791-3; Q53HV7-2: SMUG1; NbExp=4; IntAct=EBI-11959475, EBI-12275818;
CC P25791-3; O75971-2: SNAPC5; NbExp=3; IntAct=EBI-11959475, EBI-12004298;
CC P25791-3; Q13207: TBX2; NbExp=3; IntAct=EBI-11959475, EBI-2853051;
CC P25791-3; Q8TDR4: TCP10L; NbExp=3; IntAct=EBI-11959475, EBI-3923210;
CC P25791-3; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-11959475, EBI-8644516;
CC P25791-3; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-11959475, EBI-1105213;
CC P25791-3; Q8TBB0: THAP6; NbExp=3; IntAct=EBI-11959475, EBI-3925505;
CC P25791-3; Q08117-2: TLE5; NbExp=3; IntAct=EBI-11959475, EBI-11741437;
CC P25791-3; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-11959475, EBI-492476;
CC P25791-3; Q86WV8: TSC1; NbExp=3; IntAct=EBI-11959475, EBI-12806590;
CC P25791-3; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-11959475, EBI-372432;
CC P25791-3; Q7Z6J9: TSEN54; NbExp=3; IntAct=EBI-11959475, EBI-2559824;
CC P25791-3; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11959475, EBI-10241197;
CC P25791-3; Q9H2G4: TSPYL2; NbExp=3; IntAct=EBI-11959475, EBI-947459;
CC P25791-3; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-11959475, EBI-3918381;
CC P25791-3; Q8TF42: UBASH3B; NbExp=3; IntAct=EBI-11959475, EBI-1380492;
CC P25791-3; Q495M9: USH1G; NbExp=3; IntAct=EBI-11959475, EBI-8601749;
CC P25791-3; P61758: VBP1; NbExp=3; IntAct=EBI-11959475, EBI-357430;
CC P25791-3; Q14119: VEZF1; NbExp=3; IntAct=EBI-11959475, EBI-11980193;
CC P25791-3; Q2NL98: VMAC; NbExp=3; IntAct=EBI-11959475, EBI-2803134;
CC P25791-3; Q92558: WASF1; NbExp=3; IntAct=EBI-11959475, EBI-1548747;
CC P25791-3; Q5VVQ6: YOD1; NbExp=3; IntAct=EBI-11959475, EBI-2510804;
CC P25791-3; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-11959475, EBI-12030590;
CC P25791-3; O15231: ZNF185; NbExp=3; IntAct=EBI-11959475, EBI-6874731;
CC P25791-3; P17023: ZNF19; NbExp=3; IntAct=EBI-11959475, EBI-12884200;
CC P25791-3; P17028: ZNF24; NbExp=3; IntAct=EBI-11959475, EBI-707773;
CC P25791-3; P15622-3: ZNF250; NbExp=3; IntAct=EBI-11959475, EBI-10177272;
CC P25791-3; Q86VK4-3: ZNF410; NbExp=5; IntAct=EBI-11959475, EBI-11741890;
CC P25791-3; Q96N77-2: ZNF641; NbExp=3; IntAct=EBI-11959475, EBI-12939666;
CC P25791-3; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11959475, EBI-625509;
CC P25791-3; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-11959475, EBI-4395732;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=LMO2a;
CC IsoId=P25791-1; Sequence=Displayed;
CC Name=3;
CC IsoId=P25791-3; Sequence=VSP_038961;
CC Name=2;
CC IsoId=P25791-4; Sequence=VSP_038962, VSP_038963;
CC -!- DOMAIN: The second LIM zinc-binding domain interacts with KDM5A.
CC -!- DISEASE: Note=A chromosomal aberration involving LMO2 may be a cause of
CC a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation
CC t(11,14)(p13;q11) with TCRD.
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF98804.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=AAH73973.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
CC Sequence=CAA43430.1; Type=Frameshift; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/RBTN2ID34.html";
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DR EMBL; X61118; CAA43430.1; ALT_FRAME; mRNA.
DR EMBL; BC034041; AAH34041.1; -; mRNA.
DR EMBL; BC035607; AAH35607.1; -; mRNA.
DR EMBL; BC042426; AAH42426.1; -; mRNA.
DR EMBL; BC073973; AAH73973.1; ALT_SEQ; mRNA.
DR EMBL; AF257211; AAF98804.1; ALT_SEQ; mRNA.
DR CCDS; CCDS44567.1; -. [P25791-1]
DR CCDS; CCDS7888.2; -. [P25791-3]
DR PIR; S29477; S29477.
DR RefSeq; NP_001135787.1; NM_001142315.1. [P25791-1]
DR RefSeq; NP_001135788.1; NM_001142316.1. [P25791-1]
DR RefSeq; NP_005565.2; NM_005574.3. [P25791-3]
DR RefSeq; XP_005252978.1; XM_005252921.2. [P25791-1]
DR RefSeq; XP_016873216.1; XM_017017727.1. [P25791-1]
DR RefSeq; XP_016873217.1; XM_017017728.1. [P25791-1]
DR RefSeq; XP_016873218.1; XM_017017729.1. [P25791-1]
DR RefSeq; XP_016873219.1; XM_017017730.1. [P25791-1]
DR RefSeq; XP_016873220.1; XM_017017731.1. [P25791-1]
DR RefSeq; XP_016873221.1; XM_017017732.1. [P25791-1]
DR RefSeq; XP_016873222.1; XM_017017733.1. [P25791-1]
DR PDB; 2XJY; X-ray; 2.40 A; A=26-156.
DR PDB; 2XJZ; X-ray; 2.80 A; A/B/C/D/E=26-156.
DR PDB; 2YPA; X-ray; 2.80 A; C=25-156.
DR PDB; 4KFZ; X-ray; 2.80 A; A/B=9-158.
DR PDBsum; 2XJY; -.
DR PDBsum; 2XJZ; -.
DR PDBsum; 2YPA; -.
DR PDBsum; 4KFZ; -.
DR AlphaFoldDB; P25791; -.
DR BMRB; P25791; -.
DR SMR; P25791; -.
DR BioGRID; 110191; 251.
DR CORUM; P25791; -.
DR IntAct; P25791; 227.
DR MINT; P25791; -.
DR STRING; 9606.ENSP00000257818; -.
DR ChEMBL; CHEMBL3217402; -.
DR iPTMnet; P25791; -.
DR PhosphoSitePlus; P25791; -.
DR BioMuta; LMO2; -.
DR DMDM; 132533; -.
DR jPOST; P25791; -.
DR MassIVE; P25791; -.
DR MaxQB; P25791; -.
DR PaxDb; P25791; -.
DR PeptideAtlas; P25791; -.
DR PRIDE; P25791; -.
DR ProteomicsDB; 54294; -. [P25791-1]
DR ProteomicsDB; 54295; -. [P25791-3]
DR ABCD; P25791; 1 sequenced antibody.
DR Antibodypedia; 4265; 752 antibodies from 42 providers.
DR DNASU; 4005; -.
DR Ensembl; ENST00000257818.3; ENSP00000257818.2; ENSG00000135363.12. [P25791-3]
DR Ensembl; ENST00000395833.7; ENSP00000379175.3; ENSG00000135363.12. [P25791-1]
DR Ensembl; ENST00000411482.1; ENSP00000401967.1; ENSG00000135363.12. [P25791-4]
DR GeneID; 4005; -.
DR KEGG; hsa:4005; -.
DR MANE-Select; ENST00000257818.3; ENSP00000257818.2; NM_005574.4; NP_005565.2. [P25791-3]
DR UCSC; uc001mve.5; human. [P25791-1]
DR CTD; 4005; -.
DR DisGeNET; 4005; -.
DR GeneCards; LMO2; -.
DR HGNC; HGNC:6642; LMO2.
DR HPA; ENSG00000135363; Low tissue specificity.
DR MIM; 180385; gene.
DR neXtProt; NX_P25791; -.
DR OpenTargets; ENSG00000135363; -.
DR PharmGKB; PA30408; -.
DR VEuPathDB; HostDB:ENSG00000135363; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000160199; -.
DR HOGENOM; CLU_3031687_0_0_1; -.
DR InParanoid; P25791; -.
DR OMA; TTSSECR; -.
DR OrthoDB; 1307952at2759; -.
DR PhylomeDB; P25791; -.
DR TreeFam; TF351071; -.
DR PathwayCommons; P25791; -.
DR Reactome; R-HSA-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR SignaLink; P25791; -.
DR SIGNOR; P25791; -.
DR BioGRID-ORCS; 4005; 40 hits in 1086 CRISPR screens.
DR ChiTaRS; LMO2; human.
DR EvolutionaryTrace; P25791; -.
DR GeneWiki; LMO2; -.
DR GenomeRNAi; 4005; -.
DR Pharos; P25791; Tbio.
DR PRO; PR:P25791; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P25791; protein.
DR Bgee; ENSG00000135363; Expressed in monocyte and 209 other tissues.
DR Genevisible; P25791; HS.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IDA:BHF-UCL.
DR GO; GO:0043425; F:bHLH transcription factor binding; IPI:BHF-UCL.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IPI:BHF-UCL.
DR GO; GO:0003713; F:transcription coactivator activity; IDA:BHF-UCL.
DR GO; GO:0001221; F:transcription coregulator binding; IPI:BHF-UCL.
DR GO; GO:0097067; P:cellular response to thyroid hormone stimulus; IDA:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
DR IDEAL; IID00268; -.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00132; LIM; 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Chromosomal rearrangement; LIM domain;
KW Metal-binding; Nucleus; Proto-oncogene; Reference proteome; Repeat; Zinc.
FT CHAIN 1..158
FT /note="Rhombotin-2"
FT /id="PRO_0000075896"
FT DOMAIN 30..89
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 94..153
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT VAR_SEQ 1
FT /note="M -> MEGSAVTVLERGGASSPAERRSKRRRRSGGDGGGGGGARAPEGVRAP
FT AAGQPRATKGAPPPPGTPPPSPM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:1923511"
FT /id="VSP_038961"
FT VAR_SEQ 15
FT /note="E -> SLKGSQVRCPVWPKTISDPRCWSHSGEAVPDAWPSLQGTSG (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038962"
FT VAR_SEQ 16..158
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038963"
FT TURN 25..27
FT /evidence="ECO:0007829|PDB:4KFZ"
FT TURN 31..33
FT /evidence="ECO:0007829|PDB:2XJY"
FT STRAND 39..45
FT /evidence="ECO:0007829|PDB:2XJY"
FT STRAND 48..51
FT /evidence="ECO:0007829|PDB:2XJY"
FT TURN 52..54
FT /evidence="ECO:0007829|PDB:2XJY"
FT TURN 58..60
FT /evidence="ECO:0007829|PDB:2XJY"
FT TURN 64..66
FT /evidence="ECO:0007829|PDB:2XJZ"
FT STRAND 71..74
FT /evidence="ECO:0007829|PDB:2XJY"
FT STRAND 77..79
FT /evidence="ECO:0007829|PDB:2XJY"
FT HELIX 81..88
FT /evidence="ECO:0007829|PDB:2XJY"
FT TURN 95..97
FT /evidence="ECO:0007829|PDB:2XJY"
FT STRAND 105..110
FT /evidence="ECO:0007829|PDB:2XJY"
FT STRAND 113..116
FT /evidence="ECO:0007829|PDB:2XJY"
FT HELIX 117..119
FT /evidence="ECO:0007829|PDB:2XJY"
FT TURN 123..125
FT /evidence="ECO:0007829|PDB:2XJY"
FT STRAND 134..138
FT /evidence="ECO:0007829|PDB:2XJY"
FT STRAND 141..144
FT /evidence="ECO:0007829|PDB:2XJY"
FT HELIX 145..147
FT /evidence="ECO:0007829|PDB:2XJY"
FT HELIX 148..155
FT /evidence="ECO:0007829|PDB:2XJY"
SQ SEQUENCE 158 AA; 18358 MW; 1B4FF02505528C93 CRC64;
MSSAIERKSL DPSEEPVDEV LQIPPSLLTC GGCQQNIGDR YFLKAIDQYW HEDCLSCDLC
GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR IRAYEMTMRV KDKVYHLECF
KCAACQKHFC VGDRYLLINS DIVCEQDIYE WTKINGMI
