ID   RBTN2_XENTR             Reviewed;         158 AA.
AC   Q5M8V8;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Rhombotin-2;
DE   AltName: Full=LIM domain only protein 2;
DE            Short=LMO-2;
GN   Name=lmo2 {ECO:0000312|EMBL:AAH87809.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH87809.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=F6 {ECO:0000312|EMBL:AAH87809.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that acts synergistically with tal1/scl
CC       and gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate.
CC       Induces globin gene expression together with fgf (By similarity).
CC       {ECO:0000250|UniProtKB:Q90XH3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P25801}.
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DR   EMBL; BC087809; AAH87809.1; -; mRNA.
DR   RefSeq; NP_001011238.1; NM_001011238.2.
DR   AlphaFoldDB; Q5M8V8; -.
DR   SMR; Q5M8V8; -.
DR   STRING; 8364.ENSXETP00000016228; -.
DR   PaxDb; Q5M8V8; -.
DR   DNASU; 496679; -.
DR   GeneID; 496679; -.
DR   KEGG; xtr:496679; -.
DR   CTD; 4005; -.
DR   Xenbase; XB-GENE-479144; lmo2.
DR   eggNOG; KOG0490; Eukaryota.
DR   HOGENOM; CLU_001357_3_1_1; -.
DR   InParanoid; Q5M8V8; -.
DR   OMA; NIVCEDH; -.
DR   OrthoDB; 1307952at2759; -.
DR   PhylomeDB; Q5M8V8; -.
DR   TreeFam; TF351071; -.
DR   Reactome; R-XTR-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   ExpressionAtlas; Q5M8V8; differential.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032991; C:protein-containing complex; ISS:UniProtKB.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR   GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   SMART; SM00132; LIM; 2.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; LIM domain; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Zinc.
FT   CHAIN           1..158
FT                   /note="Rhombotin-2"
FT                   /id="PRO_0000318113"
FT   DOMAIN          28..90
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          92..154
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
SQ   SEQUENCE   158 AA;  18405 MW;  1DDEF04C6F729A46 CRC64;
     MSSAIERKSL DPTDEPVDEV LQIPPSLLTC GGCQQSIGDR YFLKAIDQYW HEDCLSCDLC
     GCRLGEVGRR LYYKLGRKLC RRDYLRLFGQ DGLCASCDKR IRAFEMTMRV KDKVYHLECF
     KCAACQKHFC VGDRYLLINS DIVCEQDIYE WTKLNEMM