ID   RBTR_KLEAE              Reviewed;         270 AA.
AC   P07760;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Ribitol operon repressor;
DE            Short=Rbt operon repressor;
GN   Name=rbtR;
OS   Klebsiella aerogenes (Enterobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3891331; DOI=10.1002/j.1460-2075.1985.tb03782.x;
RA   Wu J.C., Anderton-Loviny T., Smith C.A., Hartley B.S.;
RT   "Structure of wild-type and mutant repressors and of the control region of
RT   the rbt operon of Klebsiella aerogenes.";
RL   EMBO J. 4:1339-1344(1985).
CC   -!- FUNCTION: Repressor for the genes of the ribitol operon. Binds D-
CC       ribulose as an inducer.
CC   -!- DOMAIN: The C-terminal domain of this protein is probably involved in
CC       association of subunits consequent on ribitol binding.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X02448; CAA26293.1; -; Genomic_DNA.
DR   AlphaFoldDB; P07760; -.
DR   SMR; P07760; -.
DR   STRING; 548.EAG7_00525; -.
DR   PRIDE; P07760; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..270
FT                   /note="Ribitol operon repressor"
FT                   /id="PRO_0000107992"
FT   DOMAIN          1..61
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        6..25
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   270 AA;  30024 MW;  4A14B3D0405D76A6 CRC64;
     MKKITIYDLA ELSGVSASAV SAILNGNWKK RRISAKLAEK VTRIAEEQGY AINRQASMLR
     SKKSHVIGMI IPKYDNRYFG SIAERFEEMA RERGLLPIIT CTRRRPELEI EAVKAMLSWQ
     VDWVVATGAT NPDKISALCQ QAGVPTVNLD LPGSLSPSVI SDNYGGAKAL THKILANSAR
     RRGELAPLTF IGGRRATITP ASVYAASTMR IASWGLACRR RIFWLPAIRK ATLRTACRSG
     LAARRRCCRG YLLTRRYPWK GLCAGCRRWV