ID   RBTT_KLEPN              Reviewed;         427 AA.
AC   O52717;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Ribitol transporter;
GN   Name=rbtT;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1033-5P14 / KAY2026;
RX   PubMed=9324246; DOI=10.1128/jb.179.19.6014-6019.1997;
RA   Heuel H., Turgut S., Schmid K., Lengeler J.W.;
RT   "Substrate recognition domains as revealed by active hybrids between the D-
RT   arabinitol and ribitol transporters from Klebsiella pneumoniae.";
RL   J. Bacteriol. 179:6014-6019(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. CsbX subfamily. {ECO:0000305}.
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DR   EMBL; AF045244; AAC26496.1; -; Genomic_DNA.
DR   PIR; S78599; S78599.
DR   RefSeq; WP_004175116.1; NZ_WXZO01000031.1.
DR   AlphaFoldDB; O52717; -.
DR   SMR; O52717; -.
DR   TCDB; 2.A.1.18.2; the major facilitator superfamily (mfs).
DR   OMA; GWRNTVM; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004748; Polyol_permease.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00897; 2A0118; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Sugar transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..427
FT                   /note="Ribitol transporter"
FT                   /id="PRO_0000050496"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..51
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        73..79
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..107
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        129..141
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..171
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        193..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..263
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        285..295
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        317..323
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..344
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        345..360
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        382..383
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        384..404
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        405..427
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   427 AA;  47010 MW;  A9AB7EB9C26185AA CRC64;
     MSVNNKQWYG LPLNLIWGYV AIAVFMTGDG FELAFLSHYI KALGFTPAQA SFAFTLYGLA
     AALSAWVSGV VAEIITPRKA MLIGFVLWCV FHVLFLVFGL GRANYALILL FYGIRGLAYP
     LFLYSFIVAI IHNVRSDSSS SALGWFWAVY SVGIGVFGSY IPSFTIPHIG EMGTLWLALL
     FCATGGIIAL VSMRHTETPR HMQNLTTREK FAELGRAATL LYTNRSILFS SIVRIINTLS
     LFGFAVIMPM MFVDELGFTT SEWLQVWAAF FFTTIFSNVF WGIVAEKMGW MKVIRWFGCI
     GMALSSLAFY YLPQHFGHNF AMALVPAIAL GIFVAAFVPM AAVFPALEPN HKGAAISVYN
     LSAGLSNFLA PAIAVVLLPY FSTIGVVIAY TALYILAFFL CPLIRVEQPG FTSDQHAKPF
     TANAAES