RBY1B_HUMAN
ID RBY1B_HUMAN Reviewed; 496 AA.
AC A6NDE4; A6NCZ8; A6NE80; A8MSJ6;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=RNA-binding motif protein, Y chromosome, family 1 member B;
GN Name=RBMY1B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12815422; DOI=10.1038/nature01722;
RA Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT "The male-specific region of the human Y chromosome is a mosaic of discrete
RT sequence classes.";
RL Nature 423:825-837(2003).
CC -!- FUNCTION: RNA-binding protein which may be involved in spermatogenesis.
CC Required for sperm development, possibly by participating in pre-mRNA
CC splicing in the testis.
CC -!- SUBUNIT: Interacts with splicing factor proteins SFRS3/SRP20,
CC TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Testis-specific.
CC -!- DEVELOPMENTAL STAGE: Expressed in all of the transcriptionally active
CC stages of germ cell development from spermatogonia through
CC spermatocytes to round spermatids.
CC -!- MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions of
CC the Y chromosome, mostly within the AZFb region. The exact number of
CC functional copies is unclear and may vary between individuals, and some
CC of them may represent pseudogenes. The proteins are very similar, which
CC makes the characterization of each protein difficult. Thus, most
CC experiments do not discriminate between the different members. One can
CC therefore suppose that reported interactions with a RBMY1 protein
CC involve all the proteins.
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DR EMBL; AC010141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS35479.1; -.
DR RefSeq; NP_001006121.1; NM_001006121.3.
DR AlphaFoldDB; A6NDE4; -.
DR SMR; A6NDE4; -.
DR BioGRID; 132079; 1.
DR iPTMnet; A6NDE4; -.
DR PhosphoSitePlus; A6NDE4; -.
DR BioMuta; RBMY1B; -.
DR EPD; A6NDE4; -.
DR jPOST; A6NDE4; -.
DR MassIVE; A6NDE4; -.
DR PaxDb; A6NDE4; -.
DR PeptideAtlas; A6NDE4; -.
DR PRIDE; A6NDE4; -.
DR Antibodypedia; 70951; 2 antibodies from 2 providers.
DR DNASU; 378948; -.
DR Ensembl; ENST00000383020.7; ENSP00000372484.3; ENSG00000242875.6.
DR GeneID; 378948; -.
DR KEGG; hsa:378948; -.
DR MANE-Select; ENST00000383020.7; ENSP00000372484.3; NM_001006121.4; NP_001006121.1.
DR UCSC; uc004fuo.4; human.
DR CTD; 378948; -.
DR GeneCards; RBMY1B; -.
DR HGNC; HGNC:23914; RBMY1B.
DR HPA; ENSG00000242875; Tissue enriched (testis).
DR neXtProt; NX_A6NDE4; -.
DR PharmGKB; PA134872137; -.
DR VEuPathDB; HostDB:ENSG00000242875; -.
DR GeneTree; ENSGT00940000163524; -.
DR HOGENOM; CLU_042286_0_0_1; -.
DR InParanoid; A6NDE4; -.
DR OrthoDB; 1248417at2759; -.
DR PhylomeDB; A6NDE4; -.
DR TreeFam; TF331833; -.
DR PathwayCommons; A6NDE4; -.
DR BioGRID-ORCS; 378948; 8 hits in 241 CRISPR screens.
DR GenomeRNAi; 378948; -.
DR Pharos; A6NDE4; Tbio.
DR PRO; PR:A6NDE4; -.
DR Proteomes; UP000005640; Chromosome Y.
DR RNAct; A6NDE4; protein.
DR Bgee; ENSG00000242875; Expressed in right testis and 2 other tissues.
DR ExpressionAtlas; A6NDE4; baseline.
DR Genevisible; A6NDE4; HS.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; TAS:UniProtKB.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0008584; P:male gonad development; IMP:UniProtKB.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0048026; P:positive regulation of mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; TAS:UniProtKB.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR012604; RBM1CTR.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF08081; RBM1CTR; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..496
FT /note="RNA-binding motif protein, Y chromosome, family 1
FT member B"
FT /id="PRO_0000341537"
FT DOMAIN 8..85
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 67..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 55835 MW; 465F9F6BF5D72C1B CRC64;
MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD
AKNAAKDMNG KSLHGKAIKV EQAKKPSFQS GGRRRPPASS RNRSPSGSLR SARGSRGGTR
GWLPSQEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS
QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY
RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR
ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD
EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS HGAPPARGPR MSYGGSTCHA
YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA YGSSSYVASI
VDGGESRSEK GDSSRY
