RBY1E_HUMAN
ID RBY1E_HUMAN Reviewed; 496 AA.
AC A6NEQ0; A6NCW6; A6NEG9; A6NKQ5;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=RNA-binding motif protein, Y chromosome, family 1 member E;
GN Name=RBMY1E;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12815422; DOI=10.1038/nature01722;
RA Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT "The male-specific region of the human Y chromosome is a mosaic of discrete
RT sequence classes.";
RL Nature 423:825-837(2003).
CC -!- FUNCTION: RNA-binding protein which may be involved in spermatogenesis.
CC Required for sperm development, possibly by participating in pre-mRNA
CC splicing in the testis.
CC -!- SUBUNIT: Interacts with splicing factor proteins SFRS3/SRP20,
CC TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.
CC -!- INTERACTION:
CC A6NEQ0; P38159: RBMX; NbExp=3; IntAct=EBI-11958200, EBI-743526;
CC A6NEQ0; Q15415: RBMY1J; NbExp=3; IntAct=EBI-11958200, EBI-8642021;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Testis-specific.
CC -!- DEVELOPMENTAL STAGE: Expressed in all of the transcriptionally active
CC stages of germ cell development from spermatogonia through
CC spermatocytes to round spermatids.
CC -!- MISCELLANEOUS: The RBMY1 proteins are encoded by repeated regions of
CC the Y chromosome, mostly within the AZFb region. The exact number of
CC functional copies is unclear and may vary between individuals, and some
CC of them may represent pseudogenes. The proteins are very similar, which
CC makes the characterization of each protein difficult. Thus, most
CC experiments do not discriminate between the different members. One can
CC therefore suppose that reported interactions with a RBMY1 protein
CC involve all the proteins.
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DR EMBL; AC007322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS35481.1; -.
DR RefSeq; NP_001006118.2; NM_001006118.2.
DR AlphaFoldDB; A6NEQ0; -.
DR SMR; A6NEQ0; -.
DR BioGRID; 132081; 3.
DR IntAct; A6NEQ0; 2.
DR iPTMnet; A6NEQ0; -.
DR PhosphoSitePlus; A6NEQ0; -.
DR BioMuta; RBMY1E; -.
DR jPOST; A6NEQ0; -.
DR MassIVE; A6NEQ0; -.
DR PaxDb; A6NEQ0; -.
DR PeptideAtlas; A6NEQ0; -.
DR PRIDE; A6NEQ0; -.
DR ProteomicsDB; 1001; -.
DR Antibodypedia; 67094; 13 antibodies from 2 providers.
DR DNASU; 378950; -.
DR Ensembl; ENST00000382659.7; ENSP00000372105.2; ENSG00000242389.9.
DR GeneID; 378950; -.
DR KEGG; hsa:378950; -.
DR MANE-Select; ENST00000382659.7; ENSP00000372105.2; NM_001006118.3; NP_001006118.2.
DR UCSC; uc004fuw.4; human.
DR CTD; 378950; -.
DR GeneCards; RBMY1E; -.
DR HGNC; HGNC:23916; RBMY1E.
DR HPA; ENSG00000242389; Tissue enriched (testis).
DR neXtProt; NX_A6NEQ0; -.
DR PharmGKB; PA134905273; -.
DR VEuPathDB; HostDB:ENSG00000242389; -.
DR GeneTree; ENSGT00940000163524; -.
DR InParanoid; A6NEQ0; -.
DR OMA; YRAAREY; -.
DR OrthoDB; 1248417at2759; -.
DR PhylomeDB; A6NEQ0; -.
DR TreeFam; TF331833; -.
DR PathwayCommons; A6NEQ0; -.
DR SignaLink; A6NEQ0; -.
DR BioGRID-ORCS; 378950; 6 hits in 196 CRISPR screens.
DR GenomeRNAi; 378950; -.
DR Pharos; A6NEQ0; Tdark.
DR PRO; PR:A6NEQ0; -.
DR Proteomes; UP000005640; Chromosome Y.
DR RNAct; A6NEQ0; protein.
DR Bgee; ENSG00000242389; Expressed in right testis and 5 other tissues.
DR ExpressionAtlas; A6NEQ0; baseline.
DR Genevisible; A6NEQ0; HS.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR012604; RBM1CTR.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF08081; RBM1CTR; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..496
FT /note="RNA-binding motif protein, Y chromosome, family 1
FT member E"
FT /id="PRO_0000341539"
FT DOMAIN 8..85
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 67..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 55759 MW; 5FBA47366BAED27B CRC64;
MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD
AKNAAKDMNG KSLHGKAIKV EQAKKPSFQS GGRRRPPASS RNRSPSGSLR SARGSRGGTR
GWLPSQEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS
QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY
RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR
ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD
EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTA HGAPPARGPR MSYGGSTCHA
YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA CGSSSYVASI
VDGGESRSEK GDSSRY
