ID   RCAN1_BOVIN             Reviewed;         197 AA.
AC   Q3ZBP4;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Calcipressin-1;
DE   AltName: Full=Down syndrome critical region protein 1;
DE   AltName: Full=Regulator of calcineurin 1;
GN   Name=RCAN1; Synonyms=DSCR1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC       binding to the catalytic domain of calcineurin A. Could play a role
CC       during central nervous system development.
CC       {ECO:0000250|UniProtKB:Q9JHG6}.
CC   -!- SUBUNIT: Interacts with RAF1, PPP3R1 and PPP3CA.
CC       {ECO:0000250|UniProtKB:P53805, ECO:0000250|UniProtKB:Q9JHG6}.
CC   -!- PTM: Phosphorylation increases its ability to inhibit calcineurin and
CC       decreases protein half-life. {ECO:0000250|UniProtKB:P53805}.
CC   -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR   EMBL; BT030515; ABQ12955.1; -; mRNA.
DR   EMBL; BC103185; AAI03186.1; -; mRNA.
DR   RefSeq; NP_001029851.1; NM_001034679.1.
DR   AlphaFoldDB; Q3ZBP4; -.
DR   SMR; Q3ZBP4; -.
DR   STRING; 9913.ENSBTAP00000037080; -.
DR   PaxDb; Q3ZBP4; -.
DR   PRIDE; Q3ZBP4; -.
DR   Ensembl; ENSBTAT00000037243; ENSBTAP00000037080; ENSBTAG00000020035.
DR   GeneID; 539640; -.
DR   KEGG; bta:539640; -.
DR   CTD; 1827; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020035; -.
DR   VGNC; VGNC:33820; RCAN1.
DR   eggNOG; KOG4019; Eukaryota.
DR   GeneTree; ENSGT00940000159870; -.
DR   HOGENOM; CLU_076190_2_0_1; -.
DR   InParanoid; Q3ZBP4; -.
DR   OMA; DMPPVVC; -.
DR   OrthoDB; 1585262at2759; -.
DR   TreeFam; TF313579; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000020035; Expressed in gluteus medius and 105 other tissues.
DR   ExpressionAtlas; Q3ZBP4; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IEA:InterPro.
DR   GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR   GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:UniProtKB.
DR   CDD; cd12708; RRM_RCAN1; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR006931; Calcipressin.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR031271; RCAN1.
DR   InterPro; IPR034906; RCAN1_RRM.
DR   PANTHER; PTHR10300; PTHR10300; 1.
DR   PANTHER; PTHR10300:SF4; PTHR10300:SF4; 1.
DR   Pfam; PF04847; Calcipressin; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..197
FT                   /note="Calcipressin-1"
FT                   /id="PRO_0000295266"
FT   REGION          163..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53805"
FT   MOD_RES         112
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53805"
FT   MOD_RES         163
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHG6"
SQ   SEQUENCE   197 AA;  22691 MW;  27D4676C038784A8 CRC64;
     MHFRNFNYSF SSLIACVANS EIFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN
     PLSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV
     EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQENEEE DEMERMKRPK
     PKIIQTRRPE YTPIHLS