ID   RCAN1_CRIGR             Reviewed;         197 AA.
AC   O35847;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Calcipressin-1;
DE   AltName: Full=Down syndrome critical region protein 1 homolog;
DE   AltName: Full=Oxidative-induced protein Adapt78;
DE   AltName: Full=Regulator of calcineurin 1;
GN   Name=RCAN1; Synonyms=ADAPT78, DSCR1;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9185608; DOI=10.1006/abbi.1997.0109;
RA   Crawford D.R., Leahy K.P., Abramova N., Lan L., Wang Y., Davies K.J.;
RT   "Hamster adapt78 mRNA is a Down syndrome critical region homologue that is
RT   inducible by oxidative stress.";
RL   Arch. Biochem. Biophys. 342:6-12(1997).
CC   -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC       binding to the catalytic domain of calcineurin A. Could play a role
CC       during central nervous system development.
CC       {ECO:0000250|UniProtKB:Q9JHG6}.
CC   -!- SUBUNIT: Interacts with RAF1, PPP3R1 and PPP3CA.
CC       {ECO:0000250|UniProtKB:P53805, ECO:0000250|UniProtKB:Q9JHG6}.
CC   -!- INDUCTION: By oxidative stress.
CC   -!- PTM: Phosphorylation increases its ability to inhibit calcineurin and
CC       decreases protein half-life. {ECO:0000250|UniProtKB:P53805}.
CC   -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR   EMBL; U60263; AAB68517.1; -; mRNA.
DR   RefSeq; NP_001233660.1; NM_001246731.1.
DR   AlphaFoldDB; O35847; -.
DR   SMR; O35847; -.
DR   STRING; 10029.NP_001233660.1; -.
DR   Ensembl; ENSCGRT00001014165; ENSCGRP00001009945; ENSCGRG00001011944.
DR   GeneID; 100689474; -.
DR   KEGG; cge:100689474; -.
DR   CTD; 1827; -.
DR   eggNOG; KOG4019; Eukaryota.
DR   GeneTree; ENSGT00940000159870; -.
DR   OMA; DMPPVVC; -.
DR   OrthoDB; 1585262at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR   GO; GO:0031987; P:locomotion involved in locomotory behavior; IEA:Ensembl.
DR   GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:UniProtKB.
DR   GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IEA:Ensembl.
DR   GO; GO:0002931; P:response to ischemia; IEA:Ensembl.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0007614; P:short-term memory; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   CDD; cd12708; RRM_RCAN1; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR006931; Calcipressin.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR031271; RCAN1.
DR   InterPro; IPR034906; RCAN1_RRM.
DR   PANTHER; PTHR10300; PTHR10300; 1.
DR   PANTHER; PTHR10300:SF4; PTHR10300:SF4; 1.
DR   Pfam; PF04847; Calcipressin; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Stress response.
FT   CHAIN           1..197
FT                   /note="Calcipressin-1"
FT                   /id="PRO_0000211413"
FT   REGION          163..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53805"
FT   MOD_RES         112
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53805"
FT   MOD_RES         163
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHG6"
SQ   SEQUENCE   197 AA;  22675 MW;  0EFC68FA55826439 CRC64;
     MHFRDFNYNF SSLIACVANG DVFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN
     PLSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV
     EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQENEEE EEMERMKRPK
     PKIIQTRRPE YTPIHLS