ID   RCAN1_PONAB             Reviewed;         197 AA.
AC   Q5RES7;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Calcipressin-1;
DE   AltName: Full=Down syndrome critical region protein 1 homolog;
DE   AltName: Full=Regulator of calcineurin 1;
GN   Name=RCAN1; Synonyms=DSCR1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC       binding to the catalytic domain of calcineurin A. Could play a role
CC       during central nervous system development.
CC       {ECO:0000250|UniProtKB:Q9JHG6}.
CC   -!- SUBUNIT: Interacts with RAF1, PPP3R1 and PPP3CA.
CC       {ECO:0000250|UniProtKB:P53805, ECO:0000250|UniProtKB:Q9JHG6}.
CC   -!- PTM: Phosphorylation increases its ability to inhibit calcineurin and
CC       decreases protein half-life. {ECO:0000250|UniProtKB:P53805}.
CC   -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR   EMBL; CR857439; CAH89730.1; -; mRNA.
DR   RefSeq; NP_001124789.1; NM_001131317.1.
DR   AlphaFoldDB; Q5RES7; -.
DR   SMR; Q5RES7; -.
DR   STRING; 9601.ENSPPYP00000012717; -.
DR   GeneID; 100171642; -.
DR   KEGG; pon:100171642; -.
DR   CTD; 1827; -.
DR   eggNOG; KOG4019; Eukaryota.
DR   InParanoid; Q5RES7; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IEA:InterPro.
DR   GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:UniProtKB.
DR   CDD; cd12708; RRM_RCAN1; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR006931; Calcipressin.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR031271; RCAN1.
DR   InterPro; IPR034906; RCAN1_RRM.
DR   PANTHER; PTHR10300; PTHR10300; 1.
DR   PANTHER; PTHR10300:SF4; PTHR10300:SF4; 1.
DR   Pfam; PF04847; Calcipressin; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..197
FT                   /note="Calcipressin-1"
FT                   /id="PRO_0000211416"
FT   REGION          163..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        170..185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53805"
FT   MOD_RES         112
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53805"
FT   MOD_RES         163
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHG6"
SQ   SEQUENCE   197 AA;  22738 MW;  9802BDD1FAEDB238 CRC64;
     MHFRNFNYSF SSLIACVANS DIFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN
     PFSAANARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV
     EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEKEEE EEMERMKRPK
     PKIIQTRRPE YTPIHLS