RCAN1_RAT
ID RCAN1_RAT Reviewed; 199 AA.
AC Q6IN33; Q8K4S2;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Calcipressin-1;
DE AltName: Full=Down syndrome critical region protein 1 homolog;
DE AltName: Full=Myocyte-enriched calcineurin-interacting protein 1;
DE Short=MCIP1;
DE AltName: Full=Regulator of calcineurin 1;
GN Name=Rcan1; Synonyms=Dscr1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Odashima M., Nagata K., Obata K., Somura F., Izawa H., Miyazaki T.,
RA Murata Y., Seo H., Yamada Y., Yokota M.;
RT "Rat myocyte-enriched calcineurin interacting protein 1, splice variant 4
RT mRNA, complete cds.";
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC binding to the catalytic domain of calcineurin A. Could play a role
CC during central nervous system development.
CC {ECO:0000250|UniProtKB:Q9JHG6}.
CC -!- SUBUNIT: Interacts with RAF1, PPP3R1 and PPP3CA.
CC {ECO:0000250|UniProtKB:P53805, ECO:0000250|UniProtKB:Q9JHG6}.
CC -!- PTM: Phosphorylation increases its ability to inhibit calcineurin and
CC decreases protein half-life. {ECO:0000250|UniProtKB:P53805}.
CC -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR EMBL; AB075973; BAC06443.1; -; mRNA.
DR EMBL; BC072478; AAH72478.1; -; mRNA.
DR RefSeq; NP_714946.2; NM_153724.2.
DR AlphaFoldDB; Q6IN33; -.
DR SMR; Q6IN33; -.
DR IntAct; Q6IN33; 1.
DR STRING; 10116.ENSRNOP00000002715; -.
DR iPTMnet; Q6IN33; -.
DR PhosphoSitePlus; Q6IN33; -.
DR PaxDb; Q6IN33; -.
DR Ensembl; ENSRNOT00000002715; ENSRNOP00000002715; ENSRNOG00000001979.
DR GeneID; 266766; -.
DR KEGG; rno:266766; -.
DR UCSC; RGD:631338; rat.
DR CTD; 1827; -.
DR RGD; 631338; Rcan1.
DR eggNOG; KOG4019; Eukaryota.
DR GeneTree; ENSGT00940000159870; -.
DR HOGENOM; CLU_076190_2_0_1; -.
DR InParanoid; Q6IN33; -.
DR OMA; DMPPVVC; -.
DR OrthoDB; 1585262at2759; -.
DR PRO; PR:Q6IN33; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000001979; Expressed in liver and 19 other tissues.
DR Genevisible; Q6IN33; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0030346; F:protein phosphatase 2B binding; TAS:RGD.
DR GO; GO:0033173; P:calcineurin-NFAT signaling cascade; ISO:RGD.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0031987; P:locomotion involved in locomotory behavior; ISO:RGD.
DR GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:UniProtKB.
DR GO; GO:0051151; P:negative regulation of smooth muscle cell differentiation; IDA:RGD.
DR GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; ISO:RGD.
DR GO; GO:0043627; P:response to estrogen; IMP:RGD.
DR GO; GO:0002931; P:response to ischemia; ISO:RGD.
DR GO; GO:0009612; P:response to mechanical stimulus; IEP:RGD.
DR GO; GO:0006979; P:response to oxidative stress; ISO:RGD.
DR GO; GO:0007614; P:short-term memory; ISO:RGD.
DR GO; GO:0007165; P:signal transduction; TAS:RGD.
DR GO; GO:0048741; P:skeletal muscle fiber development; ISO:RGD.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEP:RGD.
DR CDD; cd12708; RRM_RCAN1; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR006931; Calcipressin.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR031271; RCAN1.
DR InterPro; IPR034906; RCAN1_RRM.
DR PANTHER; PTHR10300; PTHR10300; 1.
DR PANTHER; PTHR10300:SF4; PTHR10300:SF4; 1.
DR Pfam; PF04847; Calcipressin; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..199
FT /note="Calcipressin-1"
FT /id="PRO_0000295267"
FT REGION 162..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 108
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P53805"
FT MOD_RES 112
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P53805"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JHG6"
FT CONFLICT 70
FT /note="Q -> R (in Ref. 1; BAC06443)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 199 AA; 22948 MW; 3BA20EE4BD59F0BB CRC64;
MHFRDFNYNF SSLIACVANG DVFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN
PLSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV
EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEEEEE EEEEMERMKR
PKPKIIQTRR PEYTPIHLS
