ID   RCAN1_SHEEP             Reviewed;         197 AA.
AC   Q6XXM7;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Calcipressin-1;
DE   AltName: Full=Down syndrome critical region protein 1;
DE   AltName: Full=Regulator of calcineurin 1;
GN   Name=RCAN1; Synonyms=DSCR1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Myometrium;
RX   PubMed=12844343; DOI=10.1677/joe.0.1780117;
RA   Wu W.X., Ma X.H., Zhang Q., Chakrabarty K., Nathanielsz P.W.;
RT   "Characterization of two labor-induced genes, DSCR1 and TCTE1L, in the
RT   pregnant ovine myometrium.";
RL   J. Endocrinol. 178:117-126(2003).
CC   -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC       binding to the catalytic domain of calcineurin A. Could play a role
CC       during central nervous system development.
CC       {ECO:0000250|UniProtKB:Q9JHG6}.
CC   -!- SUBUNIT: Interacts with RAF1, PPP3R1 and PPP3CA.
CC       {ECO:0000250|UniProtKB:P53805, ECO:0000250|UniProtKB:Q9JHG6}.
CC   -!- PTM: Phosphorylation increases its ability to inhibit calcineurin and
CC       decreases protein half-life. {ECO:0000250|UniProtKB:P53805}.
CC   -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR   EMBL; AY205232; AAP38169.1; -; mRNA.
DR   RefSeq; NP_001009274.1; NM_001009274.1.
DR   AlphaFoldDB; Q6XXM7; -.
DR   SMR; Q6XXM7; -.
DR   STRING; 9940.ENSOARP00000013574; -.
DR   Ensembl; ENSOART00000013775; ENSOARP00000013574; ENSOARG00000012673.
DR   Ensembl; ENSOART00020008366; ENSOARP00020006923; ENSOARG00020005458.
DR   GeneID; 443255; -.
DR   KEGG; oas:443255; -.
DR   CTD; 1827; -.
DR   eggNOG; KOG4019; Eukaryota.
DR   HOGENOM; CLU_076190_2_0_1; -.
DR   OMA; DMPPVVC; -.
DR   OrthoDB; 1585262at2759; -.
DR   Proteomes; UP000002356; Chromosome 1.
DR   Bgee; ENSOARG00000012673; Expressed in mitral valve and 54 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR   GO; GO:0031987; P:locomotion involved in locomotory behavior; IEA:Ensembl.
DR   GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; ISS:UniProtKB.
DR   GO; GO:0043666; P:regulation of phosphoprotein phosphatase activity; IEA:Ensembl.
DR   GO; GO:0002931; P:response to ischemia; IEA:Ensembl.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0007614; P:short-term memory; IEA:Ensembl.
DR   GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl.
DR   CDD; cd12708; RRM_RCAN1; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR006931; Calcipressin.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR031271; RCAN1.
DR   InterPro; IPR034906; RCAN1_RRM.
DR   PANTHER; PTHR10300; PTHR10300; 1.
DR   PANTHER; PTHR10300:SF4; PTHR10300:SF4; 1.
DR   Pfam; PF04847; Calcipressin; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..197
FT                   /note="Calcipressin-1"
FT                   /id="PRO_0000295268"
FT   REGION          163..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53805"
FT   MOD_RES         112
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P53805"
FT   MOD_RES         163
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHG6"
SQ   SEQUENCE   197 AA;  22691 MW;  27D4676C038784A8 CRC64;
     MHFRNFNYSF SSLIACVANS EIFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN
     PLSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV
     EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQENEEE DEMERMKRPK
     PKIIQTRRPE YTPIHLS