ID   RCAN2_BOVIN             Reviewed;         197 AA.
AC   Q3ZC15; Q0IIB8; Q5E9K5;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Calcipressin-2;
DE   AltName: Full=Down syndrome candidate region 1-like 1;
DE   AltName: Full=Regulator of calcineurin 2;
GN   Name=RCAN2; Synonyms=DSCR1L1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Hereford; TISSUE=Heart ventricle, and Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC       binding to the catalytic domain of calcineurin A. Could play a role
CC       during central nervous system development (By similarity).
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3ZC15-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3ZC15-2; Sequence=VSP_026922;
CC   -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR   EMBL; BT020915; AAX08932.1; -; mRNA.
DR   EMBL; BC102981; AAI02982.1; -; mRNA.
DR   EMBL; BC122719; AAI22720.1; -; mRNA.
DR   RefSeq; NP_001015632.2; NM_001015632.2. [Q3ZC15-1]
DR   RefSeq; NP_001300961.1; NM_001314032.1. [Q3ZC15-2]
DR   AlphaFoldDB; Q3ZC15; -.
DR   SMR; Q3ZC15; -.
DR   STRING; 9913.ENSBTAP00000048923; -.
DR   PRIDE; Q3ZC15; -.
DR   Ensembl; ENSBTAT00000046658; ENSBTAP00000043934; ENSBTAG00000009302. [Q3ZC15-1]
DR   Ensembl; ENSBTAT00000053783; ENSBTAP00000048923; ENSBTAG00000009302. [Q3ZC15-2]
DR   GeneID; 525636; -.
DR   KEGG; bta:525636; -.
DR   CTD; 10231; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009302; -.
DR   eggNOG; KOG4019; Eukaryota.
DR   GeneTree; ENSGT00940000159767; -.
DR   HOGENOM; CLU_076190_2_1_1; -.
DR   InParanoid; Q3ZC15; -.
DR   OMA; RDWAITR; -.
DR   OrthoDB; 1585262at2759; -.
DR   TreeFam; TF313579; -.
DR   Proteomes; UP000009136; Chromosome 23.
DR   Bgee; ENSBTAG00000009302; Expressed in hypothalamus and 101 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR   CDD; cd12709; RRM_RCAN2; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR006931; Calcipressin.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034921; RCAN2.
DR   InterPro; IPR034919; RCAN2_RRM.
DR   PANTHER; PTHR10300; PTHR10300; 1.
DR   PANTHER; PTHR10300:SF5; PTHR10300:SF5; 1.
DR   Pfam; PF04847; Calcipressin; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Phosphoprotein; Reference proteome.
FT   CHAIN           1..197
FT                   /note="Calcipressin-2"
FT                   /id="PRO_0000295269"
FT   REGION          166..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         167
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHG2"
FT   VAR_SEQ         1..28
FT                   /note="MPAPSMDCDVSTLVACVVDVEVFTNQEV -> MRGDSYFIGMRSLGQQGHIP
FT                   EDGGLFLLCCIDRDWAVTQCFTEEAFQAITDFTDLPNSLFACNVHQSVFEGEES (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_026922"
FT   CONFLICT        10
FT                   /note="V -> A (in Ref. 1; AAX08932)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   197 AA;  21938 MW;  07E05C383F792D19 CRC64;
     MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN
     PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPASPPVG
     WQPISDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK
     PKIIQTRRPG PPPSVSN