RCAN2_HUMAN
ID RCAN2_HUMAN Reviewed; 197 AA.
AC Q14206; A6ND07; B3KR46; Q5VWF7; Q5VWF8; Q8N116;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 3.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Calcipressin-2;
DE AltName: Full=Down syndrome candidate region 1-like 1;
DE AltName: Full=Myocyte-enriched calcineurin-interacting protein 2;
DE Short=MCIP2;
DE AltName: Full=Regulator of calcineurin 2;
DE AltName: Full=Thyroid hormone-responsive protein ZAKI-4;
GN Name=RCAN2; Synonyms=DSCR1L1, ZAKI4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Fibroblast;
RX PubMed=8662924; DOI=10.1074/jbc.271.24.14567;
RA Miyazaki T., Kanou Y., Murata Y., Ohmori S., Niwa T., Maeda K.,
RA Yamamura H., Seo H.;
RT "Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in
RT human skin fibroblasts.";
RL J. Biol. Chem. 271:14567-14571(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=12102656; DOI=10.1042/bj20011797;
RA Cao X., Kambe F., Miyazaki T., Sarkar D., Ohmori S., Seo H.;
RT "Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and
RT function as calcineurin inhibitors.";
RL Biochem. J. 367:459-466(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC binding to the catalytic domain of calcineurin A. Could play a role
CC during central nervous system development.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=ZAKI-4 alpha;
CC IsoId=Q14206-1; Sequence=Displayed;
CC Name=2; Synonyms=ZAKI-4 beta;
CC IsoId=Q14206-2; Sequence=VSP_026923;
CC -!- TISSUE SPECIFICITY: Expressed in fibroblasts, heart, brain, liver, and
CC skeletal muscle but not in placenta, lung, kidney and pancreas.
CC -!- INDUCTION: By thyroid hormone.
CC -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA11911.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; D83407; BAA11911.1; ALT_INIT; mRNA.
DR EMBL; AY034085; AAK59805.1; -; mRNA.
DR EMBL; AY034086; AAK59806.1; -; mRNA.
DR EMBL; AK090990; BAG52258.1; -; mRNA.
DR EMBL; AL390741; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL359633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX04294.1; -; Genomic_DNA.
DR CCDS; CCDS43469.1; -. [Q14206-1]
DR CCDS; CCDS59023.1; -. [Q14206-2]
DR RefSeq; NP_001238902.1; NM_001251973.1. [Q14206-2]
DR RefSeq; NP_001238903.1; NM_001251974.1. [Q14206-2]
DR RefSeq; NP_005813.2; NM_005822.3. [Q14206-1]
DR RefSeq; XP_011512528.1; XM_011514226.1. [Q14206-2]
DR AlphaFoldDB; Q14206; -.
DR SMR; Q14206; -.
DR BioGRID; 115525; 23.
DR IntAct; Q14206; 18.
DR STRING; 9606.ENSP00000360425; -.
DR PhosphoSitePlus; Q14206; -.
DR BioMuta; RCAN2; -.
DR DMDM; 158958336; -.
DR MassIVE; Q14206; -.
DR PaxDb; Q14206; -.
DR PeptideAtlas; Q14206; -.
DR PRIDE; Q14206; -.
DR ProteomicsDB; 59928; -. [Q14206-1]
DR ProteomicsDB; 59929; -. [Q14206-2]
DR Antibodypedia; 30708; 241 antibodies from 30 providers.
DR DNASU; 10231; -.
DR Ensembl; ENST00000306764.11; ENSP00000305223.7; ENSG00000172348.16. [Q14206-2]
DR Ensembl; ENST00000330430.10; ENSP00000329454.6; ENSG00000172348.16. [Q14206-1]
DR Ensembl; ENST00000371374.6; ENSP00000360425.1; ENSG00000172348.16. [Q14206-2]
DR GeneID; 10231; -.
DR KEGG; hsa:10231; -.
DR MANE-Select; ENST00000371374.6; ENSP00000360425.1; NM_001251974.2; NP_001238903.1. [Q14206-2]
DR UCSC; uc003oyb.3; human. [Q14206-1]
DR CTD; 10231; -.
DR DisGeNET; 10231; -.
DR GeneCards; RCAN2; -.
DR HGNC; HGNC:3041; RCAN2.
DR HPA; ENSG00000172348; Tissue enhanced (heart muscle, tongue).
DR MIM; 604876; gene.
DR neXtProt; NX_Q14206; -.
DR OpenTargets; ENSG00000172348; -.
DR PharmGKB; PA162400959; -.
DR VEuPathDB; HostDB:ENSG00000172348; -.
DR eggNOG; KOG4019; Eukaryota.
DR GeneTree; ENSGT00940000159767; -.
DR HOGENOM; CLU_076190_2_1_1; -.
DR InParanoid; Q14206; -.
DR OMA; RDWAITR; -.
DR OrthoDB; 1585262at2759; -.
DR PhylomeDB; Q14206; -.
DR TreeFam; TF313579; -.
DR PathwayCommons; Q14206; -.
DR SignaLink; Q14206; -.
DR BioGRID-ORCS; 10231; 12 hits in 1067 CRISPR screens.
DR ChiTaRS; RCAN2; human.
DR GeneWiki; RCAN2; -.
DR GenomeRNAi; 10231; -.
DR Pharos; Q14206; Tbio.
DR PRO; PR:Q14206; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q14206; protein.
DR Bgee; ENSG00000172348; Expressed in lateral nuclear group of thalamus and 196 other tissues.
DR ExpressionAtlas; Q14206; baseline and differential.
DR Genevisible; Q14206; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR CDD; cd12709; RRM_RCAN2; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR006931; Calcipressin.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034921; RCAN2.
DR InterPro; IPR034919; RCAN2_RRM.
DR PANTHER; PTHR10300; PTHR10300; 1.
DR PANTHER; PTHR10300:SF5; PTHR10300:SF5; 1.
DR Pfam; PF04847; Calcipressin; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..197
FT /note="Calcipressin-2"
FT /id="PRO_0000211417"
FT REGION 166..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 167
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JHG2"
FT VAR_SEQ 1..28
FT /note="MPAPSMDCDVSTLVACVVDVEVFTNQEV -> MRGESYFIGMRSPGQQGHVP
FT EDGGLFLLCCIDRDWAVTRCFAEEAFQAITDFNDLPNSLFACNVHQSVFEGEES (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:12102656,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_026923"
FT CONFLICT 33
FT /note="E -> G (in Ref. 1; BAA11911 and 2; AAK59805/
FT AAK59806)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="G -> S (in Ref. 1; BAA11911 and 2; AAK59805/
FT AAK59806)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 197 AA; 21997 MW; 9FD36B3DEDAE22B8 CRC64;
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN
PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG
WQPINDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK
PKIIQTRRPG LPPSVSN
