ID   RCAN2_MACFA             Reviewed;         197 AA.
AC   Q4R4P5;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Calcipressin-2;
DE   AltName: Full=Down syndrome candidate region 1-like protein 1;
DE   AltName: Full=Regulator of calcineurin 2;
GN   Name=RCAN2; Synonyms=DSCR1L1; ORFNames=QtrA-12717;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC       binding to the catalytic domain of calcineurin A. Could play a role
CC       during central nervous system development (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR   EMBL; AB169849; BAE01930.1; -; mRNA.
DR   AlphaFoldDB; Q4R4P5; -.
DR   SMR; Q4R4P5; -.
DR   STRING; 9541.XP_005552871.1; -.
DR   eggNOG; KOG4019; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0019722; P:calcium-mediated signaling; IEA:InterPro.
DR   CDD; cd12709; RRM_RCAN2; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR006931; Calcipressin.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034921; RCAN2.
DR   InterPro; IPR034919; RCAN2_RRM.
DR   PANTHER; PTHR10300; PTHR10300; 1.
DR   PANTHER; PTHR10300:SF5; PTHR10300:SF5; 1.
DR   Pfam; PF04847; Calcipressin; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..197
FT                   /note="Calcipressin-2"
FT                   /id="PRO_0000295270"
FT   REGION          166..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         167
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHG2"
SQ   SEQUENCE   197 AA;  22096 MW;  9FC67E3DEDAE3808 CRC64;
     MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN
     PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG
     WQPINDATPV LNYDLLYAVA KLRPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK
     PKIIQTRRPG LPPSVSN