RCAN2_MOUSE
ID RCAN2_MOUSE Reviewed; 197 AA.
AC Q9JHG2; Q8VIP5;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Calcipressin-2;
DE AltName: Full=Calcineurin inhibitory protein ZAKI-4;
DE AltName: Full=Down syndrome candidate region 1-like protein 1;
DE AltName: Full=Myocyte-enriched calcineurin-interacting protein 2;
DE Short=MCIP2;
DE AltName: Full=Regulator of calcineurin 2;
GN Name=Rcan2; Synonyms=Dscr1l1, Zaki4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10722714; DOI=10.1074/jbc.275.12.8719;
RA Rothermel B., Vega R.B., Yang J., Wu H., Bassel-Duby R., Williams R.S.;
RT "A protein encoded within the Down syndrome critical region is enriched in
RT striated muscles and inhibits calcineurin signaling.";
RL J. Biol. Chem. 275:8719-8725(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=11080588; DOI=10.1016/s0378-1119(00)00407-8;
RA Strippoli P., Petrini M., Lenzi L., Carinci P., Zannotti M.;
RT "The murine DSCR1-like (Down syndrome candidate region 1) gene family:
RT conserved synteny with the human orthologous genes.";
RL Gene 257:223-232(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kanou Y., Miyazaki T., Seo H., Murata Y.;
RT "Calcineurin inhibitory protein ZAKI-4.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC binding to the catalytic domain of calcineurin A. Could play a role
CC during central nervous system development.
CC -!- TISSUE SPECIFICITY: Highest expression in heart, skeletal muscle and
CC brain. Lower expression in all other tissues.
CC -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71955.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF237791; AAF63487.1; -; mRNA.
DR EMBL; AF237887; AAF62538.1; -; mRNA.
DR EMBL; AB061524; BAB71955.1; ALT_INIT; mRNA.
DR EMBL; BC047153; AAH47153.1; -; mRNA.
DR EMBL; BC049096; AAH49096.1; -; mRNA.
DR EMBL; BC062141; AAH62141.1; -; mRNA.
DR CCDS; CCDS28801.1; -.
DR RefSeq; NP_001273583.1; NM_001286654.1.
DR RefSeq; NP_085101.1; NM_030598.2.
DR RefSeq; NP_997532.1; NM_207649.1.
DR AlphaFoldDB; Q9JHG2; -.
DR SMR; Q9JHG2; -.
DR BioGRID; 207523; 1.
DR STRING; 10090.ENSMUSP00000039473; -.
DR iPTMnet; Q9JHG2; -.
DR PhosphoSitePlus; Q9JHG2; -.
DR MaxQB; Q9JHG2; -.
DR PRIDE; Q9JHG2; -.
DR ProteomicsDB; 255136; -.
DR Antibodypedia; 30708; 241 antibodies from 30 providers.
DR DNASU; 53901; -.
DR Ensembl; ENSMUST00000044792; ENSMUSP00000048013; ENSMUSG00000039601.
DR Ensembl; ENSMUST00000177857; ENSMUSP00000137211; ENSMUSG00000039601.
DR GeneID; 53901; -.
DR KEGG; mmu:53901; -.
DR UCSC; uc008cpp.1; mouse.
DR CTD; 10231; -.
DR MGI; MGI:1858219; Rcan2.
DR VEuPathDB; HostDB:ENSMUSG00000039601; -.
DR eggNOG; KOG4019; Eukaryota.
DR GeneTree; ENSGT00940000159767; -.
DR HOGENOM; CLU_076190_2_1_1; -.
DR InParanoid; Q9JHG2; -.
DR OrthoDB; 1585262at2759; -.
DR PhylomeDB; Q9JHG2; -.
DR BioGRID-ORCS; 53901; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Rcan2; mouse.
DR PRO; PR:Q9JHG2; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9JHG2; protein.
DR Bgee; ENSMUSG00000039601; Expressed in interventricular septum and 209 other tissues.
DR ExpressionAtlas; Q9JHG2; baseline and differential.
DR Genevisible; Q9JHG2; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0033173; P:calcineurin-NFAT signaling cascade; IMP:MGI.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0031987; P:locomotion involved in locomotory behavior; IGI:MGI.
DR GO; GO:0007219; P:Notch signaling pathway; IDA:MGI.
DR GO; GO:0006979; P:response to oxidative stress; IGI:MGI.
DR GO; GO:0007614; P:short-term memory; IGI:MGI.
DR CDD; cd12709; RRM_RCAN2; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR006931; Calcipressin.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034921; RCAN2.
DR InterPro; IPR034919; RCAN2_RRM.
DR PANTHER; PTHR10300; PTHR10300; 1.
DR PANTHER; PTHR10300:SF5; PTHR10300:SF5; 1.
DR Pfam; PF04847; Calcipressin; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..197
FT /note="Calcipressin-2"
FT /id="PRO_0000211418"
FT REGION 166..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 167
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 77
FT /note="R -> K (in Ref. 3; BAB71955)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="N -> K (in Ref. 3; BAB71955)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="T -> N (in Ref. 3; BAB71955)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 197 AA; 22025 MW; CE1306B7B03E70F1 CRC64;
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD ECVTFQLFKS FRRVRINFSH
PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG
WKPISDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDME EEEDPKTSPK
PKIIQTRRPG LPPSVSN
