RCAN2_PANTR
ID RCAN2_PANTR Reviewed; 197 AA.
AC A5A6I8;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Calcipressin-2;
DE AltName: Full=Down syndrome candidate region 1-like protein 1;
DE AltName: Full=Regulator of calcineurin 2;
GN Name=RCAN2; Synonyms=DSCR1L1;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=17574350; DOI=10.1016/j.gene.2007.04.013;
RA Sakate R., Suto Y., Imanishi T., Tanoue T., Hida M., Hayasaka I.,
RA Kusuda J., Gojobori T., Hashimoto K., Hirai M.;
RT "Mapping of chimpanzee full-length cDNAs onto the human genome unveils
RT large potential divergence of the transcriptome.";
RL Gene 399:1-10(2007).
CC -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC binding to the catalytic domain of calcineurin A. Could play a role
CC during central nervous system development (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF62361.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB222116; BAF62361.1; ALT_INIT; mRNA.
DR RefSeq; NP_001098711.1; NM_001105241.1.
DR AlphaFoldDB; A5A6I8; -.
DR SMR; A5A6I8; -.
DR STRING; 9598.ENSPTRP00000031159; -.
DR PaxDb; A5A6I8; -.
DR Ensembl; ENSPTRT00000033715; ENSPTRP00000031159; ENSPTRG00000018233.
DR GeneID; 462742; -.
DR KEGG; ptr:462742; -.
DR CTD; 10231; -.
DR VGNC; VGNC:3680; RCAN2.
DR eggNOG; KOG4019; Eukaryota.
DR GeneTree; ENSGT00940000159767; -.
DR HOGENOM; CLU_076190_2_1_1; -.
DR InParanoid; A5A6I8; -.
DR TreeFam; TF313579; -.
DR Proteomes; UP000002277; Chromosome 6.
DR Bgee; ENSPTRG00000018233; Expressed in primary visual cortex and 21 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR CDD; cd12709; RRM_RCAN2; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR006931; Calcipressin.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034921; RCAN2.
DR InterPro; IPR034919; RCAN2_RRM.
DR PANTHER; PTHR10300; PTHR10300; 1.
DR PANTHER; PTHR10300:SF5; PTHR10300:SF5; 1.
DR Pfam; PF04847; Calcipressin; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..197
FT /note="Calcipressin-2"
FT /id="PRO_0000297548"
FT REGION 166..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 167
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JHG2"
SQ SEQUENCE 197 AA; 21997 MW; 9FD36B3DEDAE22B8 CRC64;
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN
PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG
WQPINDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK
PKIIQTRRPG LPPSVSN
