ID   RCAN2_RAT               Reviewed;         197 AA.
AC   Q8CH27; Q8CH26;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Calcipressin-2;
DE   AltName: Full=Calcineurin inhibitory protein ZAKI-4;
DE   AltName: Full=Down syndrome candidate region 1-like protein 1;
DE   AltName: Full=Regulator of calcineurin 2;
GN   Name=Rcan2; Synonyms=Dscr1l1, Zaki4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=Wistar; TISSUE=Brain;
RA   Miyazaki T., Cao X., Kambe F., Ohmori S., Seo H.;
RT   "Cloning of rat ZAKI-4 alpha and beta cDNA.";
RL   Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC       binding to the catalytic domain of calcineurin A. Could play a role
CC       during central nervous system development (By similarity).
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=ZAKI-4 alpha;
CC         IsoId=Q8CH27-1; Sequence=Displayed;
CC       Name=2; Synonyms=ZAKI-4 beta;
CC         IsoId=Q8CH27-2; Sequence=VSP_026924;
CC   -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR   EMBL; AF459022; AAO15540.1; -; mRNA.
DR   EMBL; AF459023; AAO15541.1; -; mRNA.
DR   EMBL; BC086974; AAH86974.1; -; mRNA.
DR   RefSeq; NP_783168.1; NM_175578.3.
DR   RefSeq; XP_006244655.1; XM_006244593.3. [Q8CH27-1]
DR   AlphaFoldDB; Q8CH27; -.
DR   SMR; Q8CH27; -.
DR   STRING; 10116.ENSRNOP00000013954; -.
DR   PhosphoSitePlus; Q8CH27; -.
DR   Ensembl; ENSRNOT00000029593; ENSRNOP00000029489; ENSRNOG00000010350. [Q8CH27-1]
DR   GeneID; 140666; -.
DR   KEGG; rno:140666; -.
DR   UCSC; RGD:69198; rat. [Q8CH27-1]
DR   CTD; 10231; -.
DR   RGD; 69198; Rcan2.
DR   eggNOG; KOG4019; Eukaryota.
DR   GeneTree; ENSGT00940000159767; -.
DR   HOGENOM; CLU_076190_2_1_1; -.
DR   InParanoid; Q8CH27; -.
DR   OrthoDB; 1585262at2759; -.
DR   PhylomeDB; Q8CH27; -.
DR   TreeFam; TF313579; -.
DR   PRO; PR:Q8CH27; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000010350; Expressed in heart and 20 other tissues.
DR   ExpressionAtlas; Q8CH27; baseline and differential.
DR   Genevisible; Q8CH27; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0033173; P:calcineurin-NFAT signaling cascade; ISO:RGD.
DR   GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR   GO; GO:0031987; P:locomotion involved in locomotory behavior; ISO:RGD.
DR   GO; GO:0007219; P:Notch signaling pathway; ISO:RGD.
DR   GO; GO:0006979; P:response to oxidative stress; ISO:RGD.
DR   GO; GO:0007614; P:short-term memory; ISO:RGD.
DR   CDD; cd12709; RRM_RCAN2; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR006931; Calcipressin.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034921; RCAN2.
DR   InterPro; IPR034919; RCAN2_RRM.
DR   PANTHER; PTHR10300; PTHR10300; 1.
DR   PANTHER; PTHR10300:SF5; PTHR10300:SF5; 1.
DR   Pfam; PF04847; Calcipressin; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Phosphoprotein; Reference proteome.
FT   CHAIN           1..197
FT                   /note="Calcipressin-2"
FT                   /id="PRO_0000295271"
FT   REGION          166..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         167
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JHG2"
FT   VAR_SEQ         1..28
FT                   /note="MPAPSMDCDVSTLVACVVDVEVFTNQEV -> MRGDAYFIGRSLGQQASVPE
FT                   DGGLFFLCCIDRDWAVTQCFAEEAFQALTDFNDLPNSLFACNVHQSVFEEEES (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_026924"
SQ   SEQUENCE   197 AA;  21991 MW;  D8C906B7A7F46F4B CRC64;
     MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD ECVTFQLFKS FRRVRINFSH
     PKAAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG
     WKPISDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDLE EEEDPKTSPK
     PKIIQTRRPG LPPSVSN