ID   RCAN3_BOVIN             Reviewed;         241 AA.
AC   Q2KIA1;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Calcipressin-3;
DE   AltName: Full=Down syndrome candidate region 1-like protein 2;
DE   AltName: Full=Regulator of calcineurin 3;
GN   Name=RCAN3; Synonyms=DSCR1L2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC       binding to the catalytic domain of calcineurin A. Could play a role
CC       during central nervous system development (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with protein phosphatase PPP3CA/calcineurin A.
CC       {ECO:0000250|UniProtKB:Q9UKA8}.
CC   -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR   EMBL; BC112714; AAI12715.1; -; mRNA.
DR   RefSeq; NP_001039410.1; NM_001045945.1.
DR   RefSeq; XP_010800832.1; XM_010802530.2.
DR   AlphaFoldDB; Q2KIA1; -.
DR   SMR; Q2KIA1; -.
DR   STRING; 9913.ENSBTAP00000023194; -.
DR   PaxDb; Q2KIA1; -.
DR   Ensembl; ENSBTAT00000023194; ENSBTAP00000023194; ENSBTAG00000017452.
DR   GeneID; 506601; -.
DR   KEGG; bta:506601; -.
DR   CTD; 11123; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017452; -.
DR   VGNC; VGNC:33822; RCAN3.
DR   eggNOG; KOG4019; Eukaryota.
DR   GeneTree; ENSGT00940000159501; -.
DR   HOGENOM; CLU_076190_0_0_1; -.
DR   InParanoid; Q2KIA1; -.
DR   OMA; RMRVNYN; -.
DR   OrthoDB; 1585262at2759; -.
DR   TreeFam; TF313579; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000017452; Expressed in oocyte and 104 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0019902; F:phosphatase binding; IEA:Ensembl.
DR   GO; GO:0031013; F:troponin I binding; IEA:Ensembl.
DR   GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR006931; Calcipressin.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR034923; RCAN3.
DR   PANTHER; PTHR10300; PTHR10300; 1.
DR   PANTHER; PTHR10300:SF6; PTHR10300:SF6; 1.
DR   Pfam; PF04847; Calcipressin; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..241
FT                   /note="Calcipressin-3"
FT                   /id="PRO_0000295272"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..203
FT                   /note="Calcineurin-binding"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UKA8"
FT   REGION          201..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..219
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   241 AA;  27425 MW;  F4F5A903E7F3F3A6 CRC64;
     MLRDTMNSWN DSQSDLCSTD HEEEEEMVFG ENEDDLEEMM DLSDLPTSLF ACRVHEAVFE
     VPEQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA ARARIELHET DFNGRKLKLY
     FAQVQMSGET RDKSYLQPPQ PAKQFLISPP ASPPVGWKQG GDATPVINYD LLCAVSKLGP
     GEKYELHAGT ESTPSVVVHV CESETEEEEE TKNPKQKITQ TRRPEPPTAA LSEPRAFDCA
     L