RCAN3_HUMAN
ID RCAN3_HUMAN Reviewed; 241 AA.
AC Q9UKA8; A4GU14; A4LA69; E3VWE2; E5L4P0; E5L4P7; E7ENV1; E7EWD8; G1FI66;
AC G1FLF0; Q5ECL3; Q5TGC6; Q9NUC8; Q9UKA7;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Calcipressin-3;
DE AltName: Full=Down syndrome candidate region 1-like protein 2;
DE AltName: Full=Myocyte-enriched calcineurin-interacting protein 3;
DE Short=MCIP3;
DE AltName: Full=Regulator of calcineurin 3;
GN Name=RCAN3; Synonyms=DSCR1L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Peripheral blood, and Placenta;
RX PubMed=10756093; DOI=10.1006/geno.2000.6127;
RA Strippoli P., Lenzi L., Petrini M., Carinci P., Zannotti M.;
RT "A new gene family including DSCR1 (Down syndrome candidate region 1) and
RT ZAKI-4: characterization from yeast to human and identification of DSCR1-
RT like 2, a novel human member (DSCR1L2).";
RL Genomics 64:252-263(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Heart;
RX PubMed=16516408; DOI=10.1016/j.gene.2005.12.029;
RA Canaider S., Facchin F., Griffoni C., Casadei R., Vitale L., Lenzi L.,
RA Frabetti F., D'Addabbo P., Carinci P., Zannotti M., Strippoli P.;
RT "Proteins encoded by human Down syndrome critical region gene 1-like 2
RT (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac
RT troponin I (TNNI3).";
RL Gene 372:128-136(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), AND ALTERNATIVE SPLICING.
RC TISSUE=Skeletal muscle;
RX PubMed=18022329; DOI=10.1016/j.gene.2007.10.006;
RA Facchin F., Canaider S., Vitale L., Frabetti F., Griffoni C., Lenzi L.,
RA Casadei R., Strippoli P.;
RT "Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein
RT isoforms.";
RL Gene 407:159-168(2008).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 5 AND 6), AND ALTERNATIVE SPLICING.
RC TISSUE=Lung, Prostate, and Testis;
RX PubMed=21961037; DOI=10.1371/journal.pone.0024508;
RA Facchin F., Vitale L., Bianconi E., Piva F., Frabetti F., Strippoli P.,
RA Casadei R., Pelleri M.C., Piovesan A., Canaider S.;
RT "Complexity of bidirectional transcription and alternative splicing at
RT human RCAN3 locus.";
RL PLoS ONE 6:E24508-E24508(2011).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP INTERACTION WITH PPP3CA.
RX PubMed=26248042; DOI=10.1371/journal.pone.0134569;
RA Guasch A., Aranguren-Ibanez A., Perez-Luque R., Aparicio D.,
RA Martinez-Hoyer S., Mulero M.C., Serrano-Candelas E., Perez-Riba M.,
RA Fita I.;
RT "Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl
RT Isomerization.";
RL PLoS ONE 10:E0134569-E0134569(2015).
CC -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC binding to the catalytic domain of calcineurin A. Could play a role
CC during central nervous system development (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with protein phosphatase PPP3CA/calcineurin A.
CC {ECO:0000269|PubMed:26248042}.
CC -!- INTERACTION:
CC Q9UKA8; Q13322: GRB10; NbExp=3; IntAct=EBI-9091952, EBI-80275;
CC Q9UKA8; P42858: HTT; NbExp=18; IntAct=EBI-9091952, EBI-466029;
CC Q9UKA8; P36406: TRIM23; NbExp=3; IntAct=EBI-9091952, EBI-740098;
CC Q9UKA8; Q13432: UNC119; NbExp=3; IntAct=EBI-9091952, EBI-711260;
CC Q9UKA8; PRO_0000037309 [P0C6X7]: rep; Xeno; NbExp=2; IntAct=EBI-9091952, EBI-25475797;
CC Q9UKA8-1; P19429: TNNI3; NbExp=3; IntAct=EBI-10762111, EBI-704146;
CC Q9UKA8-4; P19429: TNNI3; NbExp=2; IntAct=EBI-10762136, EBI-704146;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1; Synonyms=RCAN3-1a,2,3,4,5;
CC IsoId=Q9UKA8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9UKA8-2; Sequence=VSP_001319;
CC Name=3;
CC IsoId=Q9UKA8-3; Sequence=VSP_045970, VSP_045971;
CC Name=4;
CC IsoId=Q9UKA8-4; Sequence=VSP_045968, VSP_045969;
CC Name=5; Synonyms=RCAN3-2,4,5, RCAN3-1c,2,4,5;
CC IsoId=Q9UKA8-5; Sequence=VSP_047510;
CC Name=6; Synonyms=RCAN3-1,3,4,5, RCAN3-1a,3,4,5, RCAN3-1c,3,4,5;
CC IsoId=Q9UKA8-6; Sequence=VSP_054855;
CC -!- TISSUE SPECIFICITY: Highest expression in heart, skeletal muscle
CC kidney, liver and peripheral blood leukocytes. Lower expression in all
CC other tissues.
CC -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR EMBL; AF176116; AAF01684.1; -; mRNA.
DR EMBL; AF176117; AAF01685.1; -; mRNA.
DR EMBL; AY906854; AAW83514.1; -; mRNA.
DR EMBL; EF467309; ABO46010.1; -; mRNA.
DR EMBL; EF431960; ABO27184.1; -; mRNA.
DR EMBL; EF529733; ABP88933.1; -; mRNA.
DR EMBL; JN228252; AEL88283.1; -; mRNA.
DR EMBL; JN203053; AEL12453.1; -; mRNA.
DR EMBL; HQ287726; ADO15700.1; -; mRNA.
DR EMBL; HQ317421; ADR51177.1; -; mRNA.
DR EMBL; HQ317422; ADR51178.1; -; mRNA.
DR EMBL; HQ317423; ADR51179.1; -; mRNA.
DR EMBL; HQ317426; ADR51182.1; -; mRNA.
DR EMBL; HQ317427; ADR51183.1; -; mRNA.
DR EMBL; HQ317445; ADR02808.1; -; mRNA.
DR EMBL; HQ317446; ADR02809.1; -; mRNA.
DR EMBL; AL034582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471134; EAW95133.1; -; Genomic_DNA.
DR EMBL; BC035854; AAH35854.1; -; mRNA.
DR CCDS; CCDS254.1; -. [Q9UKA8-1]
DR CCDS; CCDS57979.1; -. [Q9UKA8-2]
DR CCDS; CCDS57980.1; -. [Q9UKA8-3]
DR CCDS; CCDS57981.1; -. [Q9UKA8-5]
DR CCDS; CCDS57982.1; -. [Q9UKA8-4]
DR CCDS; CCDS72730.1; -. [Q9UKA8-6]
DR RefSeq; NP_001238906.1; NM_001251977.1. [Q9UKA8-1]
DR RefSeq; NP_001238907.1; NM_001251978.1. [Q9UKA8-1]
DR RefSeq; NP_001238908.1; NM_001251979.1. [Q9UKA8-1]
DR RefSeq; NP_001238909.1; NM_001251980.1. [Q9UKA8-2]
DR RefSeq; NP_001238910.1; NM_001251981.1. [Q9UKA8-5]
DR RefSeq; NP_001238911.1; NM_001251982.1. [Q9UKA8-3]
DR RefSeq; NP_001238912.1; NM_001251983.1. [Q9UKA8-6]
DR RefSeq; NP_001238913.1; NM_001251984.1. [Q9UKA8-6]
DR RefSeq; NP_001238914.1; NM_001251985.1. [Q9UKA8-4]
DR RefSeq; NP_038469.1; NM_013441.3. [Q9UKA8-1]
DR AlphaFoldDB; Q9UKA8; -.
DR SMR; Q9UKA8; -.
DR BioGRID; 116297; 19.
DR IntAct; Q9UKA8; 17.
DR MINT; Q9UKA8; -.
DR STRING; 9606.ENSP00000363516; -.
DR iPTMnet; Q9UKA8; -.
DR PhosphoSitePlus; Q9UKA8; -.
DR BioMuta; RCAN3; -.
DR DMDM; 15213951; -.
DR EPD; Q9UKA8; -.
DR jPOST; Q9UKA8; -.
DR MassIVE; Q9UKA8; -.
DR MaxQB; Q9UKA8; -.
DR PaxDb; Q9UKA8; -.
DR PeptideAtlas; Q9UKA8; -.
DR PRIDE; Q9UKA8; -.
DR ProteomicsDB; 17228; -.
DR ProteomicsDB; 18826; -.
DR ProteomicsDB; 676; -.
DR ProteomicsDB; 84752; -. [Q9UKA8-1]
DR ProteomicsDB; 84753; -. [Q9UKA8-2]
DR Antibodypedia; 30319; 254 antibodies from 22 providers.
DR DNASU; 11123; -.
DR Ensembl; ENST00000374393.4; ENSP00000363514.2; ENSG00000117602.13. [Q9UKA8-4]
DR Ensembl; ENST00000374395.9; ENSP00000363516.3; ENSG00000117602.13. [Q9UKA8-1]
DR Ensembl; ENST00000412742.5; ENSP00000391912.2; ENSG00000117602.13. [Q9UKA8-3]
DR Ensembl; ENST00000425530.3; ENSP00000409540.2; ENSG00000117602.13. [Q9UKA8-2]
DR Ensembl; ENST00000436717.6; ENSP00000414447.3; ENSG00000117602.13. [Q9UKA8-5]
DR Ensembl; ENST00000538532.6; ENSP00000445401.2; ENSG00000117602.13. [Q9UKA8-1]
DR Ensembl; ENST00000616511.4; ENSP00000478174.1; ENSG00000117602.13. [Q9UKA8-6]
DR Ensembl; ENST00000618490.4; ENSP00000484519.1; ENSG00000117602.13. [Q9UKA8-6]
DR Ensembl; ENST00000630217.1; ENSP00000486836.1; ENSG00000117602.13. [Q9UKA8-5]
DR GeneID; 11123; -.
DR KEGG; hsa:11123; -.
DR MANE-Select; ENST00000374395.9; ENSP00000363516.3; NM_013441.4; NP_038469.1.
DR UCSC; uc001bjj.4; human. [Q9UKA8-1]
DR CTD; 11123; -.
DR DisGeNET; 11123; -.
DR GeneCards; RCAN3; -.
DR HGNC; HGNC:3042; RCAN3.
DR HPA; ENSG00000117602; Tissue enhanced (prostate).
DR MIM; 605860; gene.
DR neXtProt; NX_Q9UKA8; -.
DR OpenTargets; ENSG00000117602; -.
DR PharmGKB; PA162400972; -.
DR VEuPathDB; HostDB:ENSG00000117602; -.
DR eggNOG; KOG4019; Eukaryota.
DR GeneTree; ENSGT00940000159501; -.
DR HOGENOM; CLU_1577930_0_0_1; -.
DR InParanoid; Q9UKA8; -.
DR OMA; RMRVNYN; -.
DR PhylomeDB; Q9UKA8; -.
DR TreeFam; TF313579; -.
DR PathwayCommons; Q9UKA8; -.
DR SignaLink; Q9UKA8; -.
DR BioGRID-ORCS; 11123; 15 hits in 1072 CRISPR screens.
DR ChiTaRS; RCAN3; human.
DR GeneWiki; RCAN3; -.
DR GenomeRNAi; 11123; -.
DR Pharos; Q9UKA8; Tbio.
DR PRO; PR:Q9UKA8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9UKA8; protein.
DR Bgee; ENSG00000117602; Expressed in bronchial epithelial cell and 181 other tissues.
DR ExpressionAtlas; Q9UKA8; baseline and differential.
DR Genevisible; Q9UKA8; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IBA:GO_Central.
DR GO; GO:0019902; F:phosphatase binding; IPI:UniProtKB.
DR GO; GO:0003723; F:RNA binding; TAS:ProtInc.
DR GO; GO:0031013; F:troponin I binding; IPI:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR006931; Calcipressin.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034923; RCAN3.
DR PANTHER; PTHR10300; PTHR10300; 1.
DR PANTHER; PTHR10300:SF6; PTHR10300:SF6; 1.
DR Pfam; PF04847; Calcipressin; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..241
FT /note="Calcipressin-3"
FT /id="PRO_0000211420"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..203
FT /note="Calcineurin-binding"
FT /evidence="ECO:0000269|PubMed:26248042"
FT REGION 202..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..125
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:21961037"
FT /id="VSP_054855"
FT VAR_SEQ 66..123
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:18022329,
FT ECO:0000303|PubMed:21961037"
FT /id="VSP_047510"
FT VAR_SEQ 68..115
FT /note="FEALFTIYDDQVTFQLFKSFRRVRINFSKPEAAARARIELHETDFNGQ ->
FT NMNFTREQSRHPAWWFMSVKVKLKRKKRQKTPNRKLPRRGAPTLRPQR (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:16516408"
FT /id="VSP_045968"
FT VAR_SEQ 116..241
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16516408"
FT /id="VSP_045969"
FT VAR_SEQ 124..173
FT /note="VQMSGEVRDKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMPVINYDLLC
FT -> ERNMNFTREQSRHPAWWFMSVKVKLKRKKRQKTPNRKLPRRGAPTLRPQR (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:16516408"
FT /id="VSP_045970"
FT VAR_SEQ 124..133
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10756093"
FT /id="VSP_001319"
FT VAR_SEQ 174..241
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16516408"
FT /id="VSP_045971"
FT VARIANT 236
FT /note="T -> N (in dbSNP:rs16829813)"
FT /id="VAR_033727"
FT CONFLICT Q9UKA8-3:164
FT /note="R -> Q (in Ref. 2; ABO46010)"
FT /evidence="ECO:0000305"
FT CONFLICT Q9UKA8-4:106
FT /note="R -> Q (in Ref. 2; AAW83514)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 241 AA; 27492 MW; 91AB619F5E443FBD CRC64;
MLRDTMKSWN DSQSDLCSTD QEEEEEMIFG ENEDDLDEMM DLSDLPTSLF ACSVHEAVFE
AREQKERFEA LFTIYDDQVT FQLFKSFRRV RINFSKPEAA ARARIELHET DFNGQKLKLY
FAQVQMSGEV RDKSYLLPPQ PVKQFLISPP ASPPVGWKQS EDAMPVINYD LLCAVSKLGP
GEKYELHAGT ESTPSVVVHV CESETEEEEE TKNPKQKIAQ TRRPDPPTAA LNEPQTFDCA
L
