ID   RCAS1_CANLF             Reviewed;         213 AA.
AC   Q865S0;
DT   26-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Receptor-binding cancer antigen expressed on SiSo cells;
DE   AltName: Full=Cancer-associated surface antigen RCAS1;
DE   AltName: Full=Estrogen receptor-binding fragment-associated gene 9 protein;
GN   Name=EBAG9; Synonyms=RCAS1;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Mammary tumor;
RX   PubMed=12951425; DOI=10.1292/jvms.65.913;
RA   Okamura Y., Ma Z., Khatlani T.S., Okuda M., Une S., Nakaichi M., Taura Y.;
RT   "Molecular cloning of canine RCAS1 cDNA.";
RL   J. Vet. Med. Sci. 65:913-915(2003).
CC   -!- FUNCTION: May participate in suppression of cell proliferation and
CC       induces apoptotic cell death through activation of interleukin-1-beta
CC       converting enzyme (ICE)-like proteases. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type III
CC       membrane protein. Note=Predominantly located in the Golgi.
CC       {ECO:0000250}.
CC   -!- DOMAIN: The coiled coil domain is necessary for the homodimerization.
CC       {ECO:0000250}.
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DR   EMBL; AB083366; BAC20645.1; -; mRNA.
DR   RefSeq; NP_001002996.1; NM_001002996.1.
DR   AlphaFoldDB; Q865S0; -.
DR   SMR; Q865S0; -.
DR   STRING; 9612.ENSCAFP00000001047; -.
DR   PaxDb; Q865S0; -.
DR   GeneID; 403500; -.
DR   KEGG; cfa:403500; -.
DR   CTD; 9166; -.
DR   eggNOG; ENOG502QSN4; Eukaryota.
DR   InParanoid; Q865S0; -.
DR   OrthoDB; 1552653at2759; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   InterPro; IPR017025; Cancer-assoc_antigen_RCAS1.
DR   PANTHER; PTHR15208; PTHR15208; 1.
DR   PIRSF; PIRSF034247; RCAS1; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Coiled coil; Golgi apparatus; Membrane; Phosphoprotein;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..213
FT                   /note="Receptor-binding cancer antigen expressed on SiSo
FT                   cells"
FT                   /id="PRO_0000097194"
FT   TOPO_DOM        1..6
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..27
FT                   /note="Helical; Signal-anchor for type III membrane
FT                   protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        28..213
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          179..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          163..211
FT                   /evidence="ECO:0000255"
FT   MOD_RES         36
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O00559"
FT   MOD_RES         41
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O00559"
FT   MOD_RES         94
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:O00559"
SQ   SEQUENCE   213 AA;  24412 MW;  EC460C8222742E8E CRC64;
     MAITQFRLFK VCTCLATVFS FLKRLICRSG RGRKLSGDQI TLPTTVDYSS VPKQTDVEEW
     TSWDEDAPTS VKIEGGNGNV ATQQNALEQL EPDYFKDMTP TIRKTQKIII KKREPLNFGI
     PDGSTGFSSR LAATQDMPFI HQSPELGDLD TWQENTNAWE EEEDAAWQAE EVLRQQKIAD
     REKRAAEQQR KRMEKEAQRL MRKEQNKIGV KLS