RCBT1_MOUSE
ID RCBT1_MOUSE Reviewed; 531 AA.
AC Q6NXM2; Q8BTZ6; Q8BZV0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=RCC1 and BTB domain-containing protein 1;
DE AltName: Full=Regulator of chromosome condensation and BTB domain-containing protein 1;
GN Name=Rcbtb1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Colon, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=27486781; DOI=10.1016/j.ajhg.2016.06.017;
RA Coppieters F., Ascari G., Dannhausen K., Nikopoulos K., Peelman F.,
RA Karlstetter M., Xu M., Brachet C., Meunier I., Tsilimbaris M.K., Tsika C.,
RA Blazaki S.V., Vergult S., Farinelli P., Van Laethem T., Bauwens M.,
RA De Bruyne M., Chen R., Langmann T., Sui R., Meire F., Rivolta C.,
RA Hamel C.P., Leroy B.P., De Baere E.;
RT "Isolated and syndromic retinal dystrophy caused by biallelic mutations in
RT RCBTB1, a gene implicated in ubiquitination.";
RL Am. J. Hum. Genet. 99:470-480(2016).
CC -!- FUNCTION: May be involved in cell cycle regulation by chromatin
CC remodeling.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: In the retina, mainly expressed in the inner retina
CC with strong signals reaching up to the outer plexiform layer (at
CC protein level). {ECO:0000269|PubMed:27486781}.
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DR EMBL; AK033501; BAC28324.1; -; mRNA.
DR EMBL; AK088299; BAC40268.1; -; mRNA.
DR EMBL; BC067005; AAH67005.1; -; mRNA.
DR CCDS; CCDS27168.1; -.
DR RefSeq; NP_082040.2; NM_027764.2.
DR RefSeq; XP_006519629.1; XM_006519566.2.
DR RefSeq; XP_006519630.1; XM_006519567.2.
DR RefSeq; XP_006519631.1; XM_006519568.2.
DR RefSeq; XP_006519632.1; XM_006519569.2.
DR RefSeq; XP_017171693.1; XM_017316204.1.
DR RefSeq; XP_017171694.1; XM_017316205.1.
DR AlphaFoldDB; Q6NXM2; -.
DR SMR; Q6NXM2; -.
DR BioGRID; 214641; 1.
DR IntAct; Q6NXM2; 1.
DR STRING; 10090.ENSMUSP00000037030; -.
DR iPTMnet; Q6NXM2; -.
DR PhosphoSitePlus; Q6NXM2; -.
DR EPD; Q6NXM2; -.
DR MaxQB; Q6NXM2; -.
DR PaxDb; Q6NXM2; -.
DR PeptideAtlas; Q6NXM2; -.
DR PRIDE; Q6NXM2; -.
DR ProteomicsDB; 255052; -.
DR DNASU; 71330; -.
DR GeneID; 71330; -.
DR KEGG; mmu:71330; -.
DR UCSC; uc007ueb.2; mouse.
DR CTD; 55213; -.
DR MGI; MGI:1918580; Rcbtb1.
DR eggNOG; KOG1426; Eukaryota.
DR InParanoid; Q6NXM2; -.
DR OrthoDB; 1062377at2759; -.
DR PhylomeDB; Q6NXM2; -.
DR TreeFam; TF329478; -.
DR BioGRID-ORCS; 71330; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Rcbtb1; mouse.
DR PRO; PR:Q6NXM2; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q6NXM2; protein.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.30; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00415; RCC1; 5.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF50985; SSF50985; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 5.
PE 1: Evidence at protein level;
KW Cell cycle; Chromatin regulator; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..531
FT /note="RCC1 and BTB domain-containing protein 1"
FT /id="PRO_0000206643"
FT REPEAT 40..91
FT /note="RCC1 1"
FT REPEAT 93..145
FT /note="RCC1 2"
FT REPEAT 147..198
FT /note="RCC1 3"
FT REPEAT 199..250
FT /note="RCC1 4"
FT REPEAT 252..302
FT /note="RCC1 5"
FT REPEAT 304..356
FT /note="RCC1 6"
FT DOMAIN 370..437
FT /note="BTB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 470..499
FT /note="BTB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT CONFLICT 174
FT /note="V -> I (in Ref. 1; BAC40268)"
FT /evidence="ECO:0000305"
FT CONFLICT 369
FT /note="I -> T (in Ref. 1; BAC28324/BAC40268)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 531 AA; 58379 MW; AF542D25AB504024 CRC64;
MVDVGKWPIF TLLSPQEAGS IRKACVFGTS ANEAIYVTDN DEVFVFGLNY SNCLGTGDNQ
STLVPKKLEA LCGKKIKSLS YGSGPHVLLT TEDGVVYAWG HNGYSQLGNG TTNQGIAPVQ
VCTNLLIKQV IEVACGSHHS MALAADGELF AWGYNNCGQV GSGSTANQPT PRKVTNCLHT
KRVVNIACGQ TSSMAVLDSG EVYGWGYNGN GQLGLGNNGN QLTPVRVAAL HGMCVNQIVC
GYAHTLALTD EGLLYAWGAN TYGQLGTGSK NNLLSPTQIM VEKERVIEIA ACHSTHTSAA
KTQGGHVYMW GQCRGQSVIL PHLTHFCCTD DVFACFGTPA VSWRLLSVEH EDFLTVAESL
KKEFDSPEIA DLKFRIDGKY IHVHKAVLKI RCEHFRSMFQ SYWNEDMKEV IEIDQFSYPV
YRAFLQYLYT DTVDLPPEDA IGLLDLATSY CENRLKRLCQ HIIKRGITVE NAFSLFSAAV
RYDAEDLEEF CFKFCINHLT EVTQTAAFWQ MDGPLLKEFI AKASKCGAFK N
